Exercise reduces inflammation and cell proliferation in rat colon carcinogenesis

Medicine and Science in Sports and Exercise

Volumn 40, Issue 4, 2008, Pages 618-621

  Demarzo, Marcelo Marcos Piva ^a   Martins, Lisandra Vanessa ^a   Fernandes, Cleverson Rodrigues ^a   Herrero, Fábio Augusto ^a   Perez, Sérgio Eduardo De Andrade ^a   Turatti, Aline ^a   Garcia, Sérgio Britto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Colon cancer; COX 2; PCNA; Physical activity

Indexed keywords

CYCLINE; CYCLOOXYGENASE 2; DIMETHYLHYDRAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; COLON CARCINOGENESIS; CONTROLLED STUDY; EXERCISE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NONHUMAN; PHYSICAL ACTIVITY; PROTEIN EXPRESSION; RAT; SWIMMING;

ANIMALS; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DIMETHYLHYDRAZINES; INFLAMMATION; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, WISTAR; RISK FACTORS;

EID: 40949137868     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318163274d     Document Type: Article

References (30)

1. Barthold SW, Jonas AM. Morphogenesis of early 1,2-dimethylhydrazine- induced lesions and latent period reduction of colon carcinogenesis in mice by a variant of Citrobacter freundii. Cancer Res. 1977;37:4352-60.
2. Basterfield L, Reul JM, Mathers JC. Impact of physical activity on intestinal cancer development in mice. J Nutr. 2005;135: 3002S-8S.
3. Colbert LH, Mai V, Perkins SN, et al. Exercise and intestinal polyp development in APCMin mice. Med Sci Sports Exerc. 2003;35(10):1662-9.
4. Das UN. Anti-inflammatory nature of exercise. Nutrition. 2004; 20:323-6.
5. Demarzo MMP, Garcia SB. Exhaustive physical exercise increases the number of colonic preneoplastic lesions in untrained rats treated with a chemical carcinogen. Cancer Lett. 2004;216:31-4.
6. Fehrenbach E, Schneider ME. Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects. Sports Med. 2006;36:373-84.
7. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr. 2002;132:3456S-64S.
8. Fuku N, Ochiai M, Terada S, Fujimoto E, Nakagama H, Tabata I. Effect of running training on DMH-induced aberrant crypt foci in rat colon. Med Sci Sports Exerc. 2007;39(1):70-4.
9. Furuta Y, Hall ER, Sanduja S, Barkley T Jr, Milas L. Prostaglandin production by murine tumors as a predictor for therapeutic response to indomethacin. Cancer Res. 1998;48:3002-7.
10. Garcia SB, Turatti A, Ribeiro-Silva A, Zucoloto S. Sequential analyses of the growth of activated foci with increased expression of CD34, CD68, a-smooth muscle actin, and COX-2 in the rat colon carcinogenesis: putative markers of field cancerization and relationship with increased crypt fission rates. Mod Pathol. 2007;20:114A.
11. Itzkowitz SH, Yio X. Inflamtion and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004;287:G7-17.
12. Ji LL. Exercise-induced modulation of antioxidant defense. Ann N Y Acad Sci. 2002;959:82-92.
13. Ji LL, Gomez-Cabrera MC, Vina J. Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci. 2006;1067:425-35.
14. Kramer HF, Goodyear LJ. Exercise, MAPK, and NF-kappaB signaling in skeletal muscle. J Appl Physiol. 2007;103(1):388-95.
15. Martínez ME, Heddens D, Earnest DL, et al. Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa. J Natl Cancer Inst. 1999;91:950-3.
16. Martýnez ME, McPherson RS, Levin B, Annegers JF. Aspirin and other nonsteroidal anti-inflammatory drugs and risk of colorectal adenomatous polyps among endoscoped individuals. Cancer Epidemiol Biomarkers Prev. 1995;4:703-7.
17. McTiernan A, Yasui Y, Sorensen B, et al. Effect of a 12-month exercise intervention on patterns of cellular proliferation in colonic crypts: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2006;15:1588-97.
18. Oshima M, Dinchuk JE, Kargman SL, et al. Suppression of intestinal polyposis in Apc delta 716 knockout mice by inhibition of cyclooxygenase 2 (Cox-2). Cell. 1996;87:803-9.
19. Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S. Japan Public Health Center-Based Prospective Study Group. Plasma Creactive protein and risk of colorectal cancer in a nested case-control study: Japan Public Health Center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2006;15:690-5.
20. Park HS, Goodlad RA, Wright NA. The incidence of aberrant crypt foci and colonic carcinoma in dimethylhidrazine-treated rats varies in a site-specific manner and depends on tumor histology. Cancer Res. 1997;57:4507-10.
21. Petersen AMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98:1154-62.
22. Pugh S, Thomas GA. Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2. Gut. 1994;35:675-8.
23. Pyne DB. Exercise-induced muscle damage and inflammation: a review. Aust J Sci Med Sports. 1994;26:49-58.
24. Quadrilatero J, Hoffman-Goetz L. Physical activity and colon cancer. A systematic review of potential mechanisms. J Sports Med Phys Fitness. 2003;43:121-38.
25. Radak Z, Chung HY, Naito H, et al. Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. FASEB J. 2004;18:749-50.
26. Reddy BS, Sugie S, Lowenfels A. Effect of voluntary exercise on azoxymethane-induced colon carcinogenesis in male F344 rats. Cancer Res. 1988;48:7079-81.
27. Slattery ML, Edwards SL, Khe-Ni MA, Friedman GD, Potter JD. Physical activity and colon cancer: a public health perspective. Ann Epidemiol. 1997;7:137-45.
28. Venditti P, Di Meo S. Antioxidants, tissue damage, and endurance in trained and untrained young males rats. Arch Biochem Biophys. 1996;331:63-8.
29. Wendum D, Maliah J, Trugnan G, Flejou FJ. Cyclooxigenase-2 and its role in colorectal cancer development. Virchows Arch. 2004;445:327-33.
30. Yamada K, Yoshitake K, Sato M, Ahnen DJ. Proliferating cell nuclear antigen expression in normal, preneoplastic, and neoplastic colonic epithelium of the rat. Gastroenterology. 1992; 103:160-7.