Reversal of tolerance to nitroglycerin with vinpocetine: A role of calcitonin gene-related peptide

International Journal of Cardiology

Volumn 125, Issue 3, 2008, Pages 436-438

  Nie, Sheng Dan ^a   Hu, Chang Ping ^a   Chen, Yue Rong ^a   Wang, Shan ^a   Deng, Han Wu ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CGRP (calcitonin gene related peptide); Nitroglycerin; Tolerance; Vinpocetine

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; GLYCERYL TRINITRATE; VINPOCETINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG TOLERANCE; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; RAT; THORACIC AORTA; VASODILATATION;

ANIMALS; AORTA, THORACIC; CALCITONIN GENE-RELATED PEPTIDE; DRUG TOLERANCE; NITROGLYCERIN; PHOSPHODIESTERASE INHIBITORS; RATS; VASODILATOR AGENTS; VINCA ALKALOIDS;

EID: 40949136139     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2007.06.041     Document Type: Article

References (10)

1. Li Y.J., and Du Y.H. CGRP-mediated cardiovascular effect of nitroglycerin. Med Hypotheses 60 (2003) 693-698
2. Zhou Z.H., Deng H.W., and Li Y.J. The depressor effect of nitroglycerin is mediated by calcitonin gene-related peptide. Life Sci 69 (2001) 1313-1320
3. Zhou Z.H., Deng H.W., and Li Y.J. Involvement of calcitonin generelated peptide in the development of tolerance to nitroglycerin in the rat. Eur J Pharmacol 427 (2001) 137-141
4. Kim D., Rebalkin S.D., Pi X., Yan C., et al. Upregulation of phosphodiesterase 1A1 gene expression is associated with the development of nitrate tolerance. Circulation 104 (2001) 2338-2343
5. Booth B.P., Nolan T.D., and Fung H.L. Nitroglycerin-inhibited whole blood aggregation is partially mediated by calcitonin gene-related peptide: a neurogenic mechanism. Br J Pharmacol 122 (1997) 577-583
6. Wei E.P., Moskowitz M.A., Boccalini P., et al. Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprussideinduced vasodilation in feline cerebral arterioles. Circ Res 703 (1992) 1313-1319
7. Zhou Z.H., Jiang J.L., and Peng J. Reversal of tolerance to nitroglycerin with N-acetylcysteine or captopril: a role of calcitonin gene-related peptide. Eur J Pharmacol 439 (2002) 129-134
8. Oroszi G., Szilvassy Z., Nemeth J., et al. Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart. Eur J Pharmacol 368 (1999) R1-R3
9. De Garavilla L., Pagani E.D., Buchholz R.A., et al. Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo. Eur J Pharmacol 313 (1996) 89-96
10. Mulsch A., Oelze M., Kloss S., et al. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylate cyclase and cGMP dependent protein kinase and their downstream target vasodilator stimulated phosphoprotein in aorta. Circulation 103 (2001) 2188-2194