Nitroglycerin-inhibited whole blood aggregation is partially mediated by calcitonin gene-related peptide - A neurogenic mechanism

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 577-583

  Booth, Brian P ^a   Nolan, Timothy D ^a   Fung, Ho Leung ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Aorta; CGRP; Endothelium derived relaxing factor (EDRF); Neuropeptides; Nitroglycerin; Whole blood aggregation

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GLYCERYL TRINITRATE; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOCYTE AGGREGATION INHIBITION; VASCULAR TISSUE;

ADENOSINE DIPHOSPHATE; ANIMALS; AORTA; CALCITONIN GENE-RELATED PEPTIDE; ELECTRIC IMPEDANCE; MALE; NEUROTRANSMITTER AGENTS; NITROGLYCERIN; OMEGA-N-METHYLARGININE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0030986409     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701408     Document Type: Article

References (51)

1. AHLNER, J., ANDERSSON, R.G.G., AXELSSON, K.L., BUNNORS, I. & WALLENTIN, L. (1985). Effects of dipyramidamole on glyceryl trinitrate-induced inhibition of coronary artery muscle tone and platelet aggregation in relation to cyclic nucleotide metabolism. Acta Pharmacol. Toxicol., 57, 88-95.
2. ALLESCHER, H.D., KURJAK, M., HUBER, A., TRUDRUNG, P. & SCHUSDZIARRA, V. (1996). Regulation of VIP release from rat enteric nerve terminals: evidence for a stimulatory effect of NO. Am. J. Physiol., 271, G568-G574.
3. AMANO, M., TAKAHASHI, M., KOSAKA, T. & KINOSHITA, M. (1994). Differential inhibition of platelet aggregation and calcium mobilization by nitroglycerin and stabilized nitric oxide. J. Cardiovasc. Pharmacol., 24, 860-866.
4. ANDREWS, R., MAY, J.A., VICKERS, J. & HEPTINSTALL, S. (1994). Inhibition of platelet aggregation by transdermal glyceryl trinitrate. Br. Heart J., 72, 575-579.
5. ARMSTRONG, PW., ARMSTRONG, JA. & MARKS, G.S. (1980). Pharmacokinetic-hemodynamic studies of intravenous nitroglycerin in congestive cardiac failure. Circulation, 62, 160-166.
6. BAUER, J.A. & FUNG, H.-L. (1991). Concurrent hydralazine administration prevents nitroglycerin-induced hemodynamic tolerance in experimental heart failure. Circulation, 84, 35-39.
7. BENJAMIN, N., DUTTON, J.A.E. & RITTER, J.M. (1991). Human vascular smooth muscle cells inhibit platelet aggregation when incubated with glyceryl trinitrate: evidence for generation of nitric oxide. Br. J. Pharmacol., 102, 847-850.
8. BOOTH, B.P., JACOB, S., BAUER, J.A. & FUNG, H.-L. (1996). Sustained antiplatelet properties of nitroglycerin during hemodynamic tolerance in rats. J. Cardiovasc. Pharmacol., 28, 432-438.
9. BRAIN, S.D., WILLIAMS, T.J., MORRIS, H.R. & MACINTYRE, I. (1985). Calcitonin gene-related peptide is a potent vasodilator. Nature, 313, 54-56.
10. BULL, H.A., HOTHERSALL, J., CHOWDHURY, N., COHEN, J. & DOWD, P.M. (1996). Neuropeptides induce release of nitric oxide from human dermal microvascular endothelial cells. J. Invest. Dermatol., 106, 655-660.
11. CHIRKOV, Y.Y., NAUJALIS, J.I., BARBER, S., SAGE, R.E., GOVE, D.W., BREALEY, J.K. & HOROWITZ, J.D. (1992). Reversal of human platelet aggregation by low concentrations of nitroglycerin in vitro in normal subjects. Am. J. Cardiol., 70, 802-806.
12. CHUNG S.J. & FUNG, H.-L. (1990). Identification of the subcellular site for nitroglycerin metabolism to nitric oxide in bovine coronary artery smooth muscle. J. Pharmacol. Exp. Ther., 253, 614-619.
13. CRESKOFF, A.J., FITZ-HUGHES, T. & FARRIS, E.J. (1963). Hematology of the rat- methods and standards. In The Rat in Laboratory Investigations. ed. Farris, E.J. & Griffin, J.Q. pp. 406-413. New York: Hafner Publishing Co.
14. DIODATI, J.G., CANNON, R.O., HUSSAIN, N. & QUYUMI, A.A. (1995). Inhibitory effect of nitroglycerin and sodium nitroprusside on platelet activation across the coronary circulation in stable angina pectoris. Am. J. Cardiol., 75, 443-448.
15. DIODATI, J.G., THEROUX, P., LATOUR, J.-G., LACOSTE, L., LAM, J.Y.T. & WATERS, D. (1990). The effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina pectoris and acute myocardial infarction. J. Am. Coll. Cardiol., 17, 683-688.
16. EVANS, T.J., BUTTERY, L.D., CARPENTER, A., SPRINGALL, D.R., POLAK, J.M. & COHEN, J. (1996). Cytokine-treated neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria. Proc. Natl. Acad. Sci. U.S.A., 93, 9553-9558.
17. FANCIULLACCI, M., ALESSANDRI, M., FIGINI, M., GEPPETTI, P. & MICHELACCI, S. (1995). Increase in plasma calcitonin gene-related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain, 30, 119-123.
18. FEELISCH, M., BRANDS, F. & KELM, M. (1995). Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms. Eur. J. Clin. Invest., 25, 737-745.
19. GRAY, D.W. & MARSHALL, I. (1992a). Nitric oxide synthesis inhibitors attenuate calcitonin gene-related peptide endothelium-dependent vasorelaxation in rat aorta. Eur. J. Pharmacol., 212, 37-42.
20. GRAY, D.W. & MARSHALL, I. (1992b). Human α-calcitonin gene-related peptide stimulates adenylate cyclase and guanylate cyclase and relaxes rat thoracic aorta by releasing nitric oxide. Br. J. Pharmacol., 107, 691-696.
21. GULBENKIAN, S., MERIGHI, A., WHARTON, J., VARNDELL, I.M. & POLAK, J.M. (1986). Ultrastructural evidence for the co-existence of calcitonin gene-related peptide and substance P in secretory vesicles of peripheral nerves in guinea pig. J. Neurobiol., 15, 535-542.
22. HOURANI, S.M.O. & CUSACK, N.J. (1991). Pharmacological receptors on blood platelets. J. Pharmacol. Exp. Ther., 43, 243-298.
23. HUGHES, S.R. & BRAIN, S.D. (1994). Nitric oxide-dependent release of vasodilator quantities of calcitonin gene-related peptide from capsaicin-sensitive nerves in rabbit skin. Br. J. Pharmacol., 111, 425-430.
24. JANSEN, L., MORTENSEN, A. & EDVINSSON, L. (1991). Characterization of calcitonin gene-related peptide receptors in human cerebral vessels. Vasomotor responses and cAMP accumulation. Ann. New York Acad. Sci., 632, 435-440.
25. KITAMURA, K., KANGAWA, K., KAWAMOTO, M., ICHIKI, Y., MATSUO, H. & ETO, T. (1992). Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma. Biophys. Biochem. Res. Commun., 185, 134-141.
26. KUROIWA, M., AOKI, H., KOBAYASHI, S., NISHIMURA, J. & KANAIDE, H. (1995). Mechanism of endothelium-dependent relaxation induced by substance P in the coronary artery of the pig. Br. J. Pharmacol., 116, 2040-2047.
27. LIPPE, I.T., SAMETZ, W., SABIN, K. & HOLZER, P. (1993). Inhibitory role of capsaicin-sensitive afferent neurons and nitric oxide in hemostasis. Am. J. Physiol., 265, H1864-1868.
28. MARKOVITZ, J.H. & MATTHEWS, K.A. (1991). Platelets and coronary heart disease: potential psychophysiologic mechanisms. Psychosomatic Med., 53, 643-668.
29. MARSHALL, I. (1991). Mechanism of vascular relaxation by the calcitonin gene-related peptide. Ann. New York Acad. Sci., 632, 204-215.
30. MCGILLIS, J.P., HUMPHREYS, S. & REID, S. (1991). Characterization of functional calcitonin gene-related peptide receptors on rat lymphocytes. J. Immunol., 147, 3482-3489.
31. MEHTA, J.L., CHEN, L.Y., KONE, C., MEHTA, P. & TURNER, P. (1995). Identification of constitutive and inducible forms of nitric oxide synthase in human platelets. J. Lab. Clin. Med., 125, 370-377.
32. MEHTA, J.L. & MEHTA, P. (1979). Platelet function studies in heart disease. VI. Enhanced platelet aggregate formation activity in congestive heart failure: Inhibition by sodium nitroprusside. Circulation, 60, 497-503.
33. MEHTA, J.L. & MEHTA, P. (1980). Comparative effects of nitroprusside and nitroglycerin on platelet aggregation in patients with heart failure. J. Cardiovasc. Pharmacol., 2, 25-33.
34. MELLION, B.T., IGNARRO, L.J., OHLSTEIN, E.H., PONTECORVO, E.G., HYMAN, A.L. & KADOWITZ, P.J. (1981). Evidence for the inhibitory role of guanosine 3′,5′-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. Blood, 57, 946-955.
35. MILES, A.M., OWENS, M.W., MILLIGAN, S., JOHNSON, G.G., FIELDS, J.Z., ING, T.S., KOTTAPALLI, V., KESHAVARZIAN, A. & GRISHAM, M.B. (1995). Nitric oxide synthase in circulating vs extravasated polymorphonuclear leukocytes. J. Leukocyte Biol., 58, 616-622.
36. 8-37, a calcitonin gene-related peptide receptor antagonist. J. Med. Chem., 35, 2163-2168.
37. MULLDERRY, P.K., GHATEL, M.A., RODRIGO, J., ALLEN, J.M., ROSENFELD, M.G., POLAK, J.M. & BLOOM, S.R. (1985). Calcitonin gene-related peptide in cardiovascular tissues of the rat. Neuroscience, 14, 947-954.
38. MURUGANANDAM, A. & MUTUS, B. (1994). Isolation of nitric oxide synthase from human platelets. Biochem. Biophys. Acta, 1200, 1-6.
39. + channels. Nature, 344, 770-773.
40. POYNER, D.R. (1992). Calcitonin gene-related peptide: multiple actions, multiple receptors. Pharmacol. Ther., 56, 23-51.
41. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1990a). Characterization of the L-arginine: nitric oxide pathway in human platelets. Br. J. Pharmacol., 101, 325-328.
42. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1990b). An L-arginine/nitric oxide pathway present in human platelets regulates aggregation. Proc. Natl. Acad. Sci. U.S.A., 87, 5193-5197.
43. REILING, N., KRONCKE, R., ULMER, A.J., GERDES, J., FLAD, H.D. & HAUSCHILDT, S. (1996). Nitric oxide synthase: expression of endothelial, Ca2+/calmodulin-dependent isoform in human B and T lymphocytes. Eur. J. Immunol., 26, 511-516.
44. RICHTER, J., ANDERSSON, R., EDVINSSON, L. & GULLBERG, U. (1992). Calcitonin gene-related peptide (CGRP) activates human neutrophils-inhibition by chemotactic peptide antagonist BOC-MLP. Immunology, 77, 416-421.
45. SALMIVIRTA, M., LIDHOLT, K. & LINDAHL, U. (1996). Heparan sulfate: a piece of information. FASEB J., 10, 1270-1279.
46. SASAKI, Y., KAMADA, T., HAYASHI, N., SATO, N., KASAHARA, A., FUSAMOTO, H., SHIOSAKA, S., TOHYYAMA, M. & SHIOTANI, Y. (1984). Immunohistochemical distribution of glucagon, substance P, and vasoactive intestinal peptide in hepatic vasculature of the rat. Hepatology, 4, 1184-1189.
47. SCHAFER, A.I., ALEXANDER, R.W. & HANDIN, R.I. (1980). Inhibition of platelet function by organic nitrate vasodilators. Blood, 55, 649-654.
48. SHAH, P.K. (1991). Pathophysiology of unstable angina. Cardiol. Clinics, 9, 11-26.
49. STAMLER, J.S. & LOSCALZO, J. (1991). The antiplatelet properties of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J. Am. Coll. Cardiol., 18, 1529-1536.
50. VIOLARIS, A.G., MELKERT, R., HERMAN, J.-P.R. & SERRUYS, P.W. (1996). Role of angiographically identifiable thrombus on long-term luminal narrowing after coronary angioplasty; A quantitative angiographic analysis. Circulation, 93, 889-897
51. WEI, E.P., MOSKOWITZ, M.A., BOCCALINI, P. & KONTOS, H.A. (1992). Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation feline cerebral arterioles. Circ. Res., 70, 1313-1319.