Large-conductance calcium-activated potassium channels modulate vascular tone in experimental cirrhosis

Liver International

Volumn 28, Issue 4, 2008, Pages 566-573

  Rodríguez Vilarrupla, Aina ^a   Graupera, Mariona ^a   Matei, Vasilica ^a   Bataller, Ramón ^a   Abraldes, Juan G ^a   Bosch, Jaume ^a   García Pagán, Joan Carles ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

BKCa expression; Nitric oxide; Perfused livers; Portal pressure; Real time PCR

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CARBON TETRACHLORIDE; IBERIOTOXIN; MESSENGER RNA; METHOXAMINE; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE INHIBITOR;

ALPHA CHAIN; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CELL ISOLATION; CONTROLLED STUDY; LIVER CIRRHOSIS; LIVER HOMOGENATE; LIVER PERFUSION; NONHUMAN; PERFUSION PRESSURE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RNA EXTRACTION; UPREGULATION; VASCULAR RESISTANCE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CARBON TETRACHLORIDE; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HEPATOCYTES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LIVER CIRRHOSIS; MALE; POLYMERASE CHAIN REACTION; RANDOM ALLOCATION; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; VASCULAR RESISTANCE;

EID: 40949127068     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2008.01668.x     Document Type: Article

References (38)

1. Bosch J, Garcia-Pagan JC. Complications of cirrhosis. I. Portal hypertension. J Hepatol 2000; 32 (Suppl. 1): 141-56.
2. Wiest R, Groszmann RJ. Nitric oxide and portal hypertension: Its role in the regulation of intrahepatic and splanchnic vascular resistance. Semin Liver Dis 1999; 19: 411-26.
3. Shah V, Toruner M, Haddad F, et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999; 117: 1222-8.
4. Gupta TK, Toruner M, Chung MK, Groszmann RJ. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998; 28: 926-31.
5. Graupera M, Garcia-Pagan JC, Titos E, et al. 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: A possible role of cysteinyl-leukotrienes. Gastroenterology 2002; 122: 387-93.
6. Bosch J, Arroyo V, Betriu A, et al. Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis. Gastroenterology 1980; 78: 92-9.
7. Leivas A, Jimenez W, Bruix J, et al. Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: Relationship with hepatic hemodynamics. J Vasc Res 1998; 35: 186-93.
8. Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: Implications for regulation of portal pressure and resistance. Hepatology 1996; 24: 233-40.
9. Jackson WF. Ion channels and vascular tone. Hypertension 2000; 35 (Part 2): 173-8.
10. Ghatta S, Nimmagadda D, Xu X, O'rourke ST. Large-conductance, calcium-activated potassium channels: Structural and functional implications. Pharmacol Ther 2006; 110: 103-16.
11. Jiang Z, Wallner M, Meera P, Toro L. Human and rodent MaxiK channel beta-subunit genes: Cloning and characterization. Genomics 1999; 55: 57-67.
12. + channels: A transmembrane beta-subunit homolog. Proc Natl Acad Sci USA 1999; 96: 4137-42.
13. Behrens R, Nolting A, Reimann F, Schwarz M, Waldschutz R, Pongs O. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. FEBS Lett 2000; 474: 99-106.
14. Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol 1995; 268 (Part 1): C799-822.
15. Arima S, Endo Y, Yaoita H, et al. Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arteriole. J Clin Invest 1997; 100: 2816-23.
16. Bychkov R, Gollasch M, Steinke T, Ried C, Luft FC, Haller H. Calcium-activated potassium channels and nitrate-induced vasodilation in human coronary arteries. J Pharmacol Exp Ther 1998; 285: 293-8.
17. Wang R, Wu L, Wang Z. The direct effect of carbon monoxide on KCa channels in vascular smooth muscle cells. Pflugers Arch 1997; 434: 285-91.
18. (+) channels. Circulation 2001; 103: 1992-8.
19. Coleman HA, Tare M, Parkington HC. Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease. Clin Exp Pharmacol Physiol 2004; 31: 641-9.
20. (+) channels that modulate the effects of endothelin-1 and nitric oxide. J Hepatol 2001; 35: 739-48.
21. Graupera M, Garcia-Pagan JC, Abraldes JG, et al. Cyclooxygenase-derived products modulate the increased intrahepatic resistance of cirrhotic rat livers. Hepatology 2003; 37: 172-81.
22. Zhang JX, Pegoli W, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am J Physiol 1994; 266 (Part 1): G624-32.
23. Graupera M, March S, Engel P, Rodes J, Bosch J, Garcia-Pagan JC. Sinusoidal endothelial COX-1-derived prostanoids modulate the hepatic vascular tone of cirrhotic rat livers. Am J Physiol Gastrointest Liver Physiol 2005; 288: G763-70.
24. Bataller R, Gasull X, Gines P, et al. In vitro and in vivo activation of rat hepatic stellate cells results in de novo expression of L-type voltage-operated calcium channels. Hepatology 2001; 33: 956-62.
25. Sancho-Bru P, Bataller R, Gasull X, et al. Genomic and functional characterization of stellate cells isolated from human cirrhotic livers. J Hepatol 2005; 43: 272-82.
26. Geerts A, Niki T, Hellemans K, et al. Purification of rat hepatic stellate cells by side scatter-activated cell sorting. Hepatology 1998; 27: 590-8.
27. Gracia-Sancho J, Laviña B, Rodriguez-Vilarrupla A, Garcia-Caldero H, Bosch J, Garcia-Pagan JC. Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers. J Hepatol 2007; 47: 220-7.
28. + channels (rSlo). Mol Cells 2001; 12: 97-102.
29. Abderrahmane A, Salvail D, Dumoulin M, Garon J, Cadieux A, Rousseau E. Direct activation of K-Ca channel in airway smooth muscle by nitric oxide: Involvement of a nitrothiosylation mechanism? Am J Resp Cell Mol Biol 1998; 19: 485-97.
30. Sobey CG. Potassium channel function in vascular disease. Arterioscler Thromb Vasc Biol 2001; 21: 28-38.
31. Cox RH. Changes in the expression and function of arterial potassium channels during hypertension. Vascul Pharmacol 2002; 38: 13-23.
32. Korovkina VP, England SK. Detection and implications of potassium channel alterations. Vascul Pharmacol 2002; 38: 3-12.
33. Garcia-Pagan JC, Bosch J, Rodes J. The role of vasoactive mediators in portal hypertension. Semin Gastrointest Dis 1995; 6: 140-7.
34. + channels (BK(Ca)) in smooth muscle cells isolated from the rat mesenteric artery. Br J Pharmacol 1998; 124: 1131-40.
35. Patterson AJ, Henrie-Olson J, Brenner R. Vasoregulation at the molecular level: A role for the beta1 subunit of the calcium-activated potassium (BK) channel. Trends Cardiovasc Med 2002; 12: 78-82.
36. Barman SA, Zhu S, Han G, White RE. cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase. Am J Physiol Lung Cell Mol Physiol 2003; 284: L1004-11.
37. (+) channel. Biophys J 2004; 86: 2871-82.
38. Park SM, Liu G, Kubal A, Fury M, Cao L, Marx SO. Direct interaction between BKCa potassium channel and microtubule-associated protein 1A. FEBS Lett 2004; 570: 143-8.