Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: Interaction with dopamine, serotonin, and norepinephrine transporters

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 2769-2778

  Mishra, Manoj ^a   Kolhatkar, Rohit ^a   Zhen, Juan ^b   Parrington, Ingrid ^b   Reith, Maarten E A ^b   Dutta, Aloke K ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY   (United States)

Author keywords

Cocaine; Dopamine transporter; Norepinephrine transporter; Serotonin transporter

Indexed keywords

(6 BENZHYDRYL PIPERIDIN 3 YL)BENZYLAMINE; BENZILIC ACID; BENZYLAMINE DERIVATIVE; DIAMINE; DOPAMINE TRANSPORTER; HYDROXYL GROUP; NONANE; NORADRENALIN TRANSPORTER; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ARTICLE; BRAIN; CHEMICAL INTERACTION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DRUG BINDING; DRUG POTENCY; MOLECULE; NONHUMAN; RAT;

ALKANES; BENZYLAMINES; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; HYDROXYLATION; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYMPORTERS;

EID: 40949116669     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.009     Document Type: Article

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