The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding

Journal of Thrombosis and Haemostasis

Volumn 6, Issue 4, 2008, Pages 669-676

  Chang, C H ^a   Chung, C H ^a   Kuo, H L ^a   Hsu, C C ^a   Huang, Tur Fu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

C type lectin proteins aggregation; Platelet glycoprotein VI; Signal transduction; Trowaglerix

Indexed keywords

ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; COLLAGEN; CONVULXIN; GLYCOPROTEIN IB; GLYCOPROTEIN VI; ILOMASTAT; LECTIN; MATRIX METALLOPROTEINASE; TROWAGLERIX; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ARTICLE; BINDING ASSAY; BIOTINYLATION; CONCENTRATION RESPONSE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOBLOTTING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SNAKE; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA;

ANIMALS; BLEEDING TIME; COLLAGEN; CROTALID VENOMS; DIPEPTIDES; HUMANS; LECTINS, C-TYPE; MATRIX METALLOPROTEINASES; MOLECULAR WEIGHT; PHOSPHORYLATION; PLATELET ACTIVATION; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PLATELET MEMBRANE GLYCOPROTEINS; PLATELET-RICH PLASMA; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; SIGNAL TRANSDUCTION; VIPERIDAE;

EID: 40949114110     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2008.02914.x     Document Type: Article

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