Screening and evaluation of antioxidant activity of some pyridazine derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 23, Issue 2, 2008, Pages 225-229

  Çalişkan Ergün, Burcu ^a   Şüküroǧlu, Murat ^a   Coban, Tulay ^b   Banoǧlu, Erden ^a   Suzen, Sibel ^b  

^a GAZI UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Anti inflammatory; Antioxidant; Pyridazine; Pyridazine 3 one

Indexed keywords

6 CHLOROPYRIDAZINE DERIVATIVE; 6 PYRAZOLE 2H PYRIDAZIN 3 ONE DERIVATIVE; ALPHA TOCOPHEROL; ANTIOXIDANT; NITRIC OXIDE; PYRIDAZINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY DISEASE; LIPID PEROXIDATION; PRIORITY JOURNAL; SCAVENGING SYSTEM; TISSUE INJURY;

ANTIOXIDANTS; CHLORINE COMPOUNDS; DRUG EVALUATION, PRECLINICAL; LIPID PEROXIDATION; MOLECULAR STRUCTURE; PYRIDAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; SUPEROXIDES;

EID: 40949112741     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756360701475167     Document Type: Article

References (20)

1. Suzen, S. (2006) Recent developments of melatonin related antioxidant compounds. Com Chem High Thorough Synt, 9:6, pp. 409-419.
2. Suzen, S., Bozkaya, P., Coban, T. and Nebioǧlu, D. (2006) Investigation of in vitro antioxidant behavior of some 2-phenylindole derivatives: Discussion on possible antioxidant mechanisms and comparison with melatonin. J Enz Inhib Med Chem, 21:4, pp. 405-411.
3. Gurer-Orhan, H., Orhan, H., Püsküllü, MO, Buyukbingol, E. and Suzen, S. (2006) Synthesis and evaluation of in vitro antioxidant capacities of some benzimidazole derivatives. J Enz Inhib Med Chem, 21:2, pp. 241-247.
4. Kots, AY, Grafov, MA, Khropov, YV, Betin, VL, Belushkina, NN, Busygina, OG, Yazykova, MY, Ovchinnikov IV, Kulikov AS, Makhova, NN, Medvedeva, NA, Bulargina, V. and Severina, IS (2000) Vasorelaxant and antiplatelet activity of 4,7-dimethyl-1,2, 5-oxadiazolo[3,4-d]pyridazine 1,5,6-trioxide: Role of soluble guanylate cyclase, nitric oxide and thiols. Br J Pharmacol, 129:6, pp. 1163-1177.
5. Moreau, S., Coudert, P., Rubat, C., Vallee-Goyet, D., Gardette, D., Gramain, JC and Couquelet, J. (1998) Synthesis and anticonvulsant properties of triazolo- and imidazopyridazinyl carboxamides and carboxylic acids. Bioorg Med Chem, 6:7, pp. 983-991.
6. Gil-Longo, J., Laguna, M de los Reyes, Verde, I., Castro, ME, Orallo, F., Fontenla, JA, Calleja, JM, Ravina, E. and Teran, C. (1993) Pyridazine derivatives. XI: Antihypertensive activity of 3-hydrazinocycloheptyl[1,2-c]pyridazine and its hydrazone derivatives. J Pharm Sci, 82:3, pp. 286-290.
7. Ostby, OB, Gundersen, LL, Rise, F., Antonsen, O., Fosnes, K., Larsen, V., Bast, A., Custers, I. and Haenen, GR (2001) Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties. Arch Pharm (Weinheim), 334:1, pp. 21-24.
8. Imada, I., Sato, EF, Miyamoto, M., Ichimori, Y., Minamiyama, Y., Konaka, R. and Inoue, M. (1999) Analysis of reactive oxygen species generated by neutrophils using a chemiluminescence probe L-012. Anal Biochem, 271:1, pp. 53-58.
9. Cuzzocrea, S. (2006) Role of nitric oxide and reactive oxygen species in arthritis. Curr Pharm Res, 12:27, pp. 3551-3570.
10. Supinski, G. and Callahan, LA (2007) Free radical mediated skeletal muscle dysfunction in inflammatory conditions. J Appl Physiol, 102, pp. 1649-1657.
11. Peake, JM, Suzuki, K. and Coombes, JS (2007) The influence of antioxidant supplementation on markers of inflammation and the relationship to oxidative stress after exercise. J Nutr Biochem, 18, pp. 357-371.
12. Craft, JM, Watterson, DM, Frautschy, SA and Van Eldik, LJ (2004) Aminopyridazines inhibit β-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging, 25:10, pp. 1283-1292.
13. Banoǧlu, E., Akoǧlu, C., Ünlü, S., Küpeli, E., Yesilada, E. and Sahin, MF (2004) Amide derivatives of [6-(5-methyl-3-phenylpyrazol-1-yl)-3(2H)-pyrazinone-2-yl]acetic acids as potential analgesic and anti-inflammatory compounds. Arch Pharm Pharm Med Chem, 337, pp. 7-14.
14. Banoǧlu, E., Akoǧlu, C., Ünlü, S., Üalüskan-Ergun, B., Küpeli, E., Yesilada, E. and Sahin, MF (2005) Synthesis of amide derivatives of [6-(3,5-dimethylpyrazol-1-yl)-3(2H)-pyrazinone-2-yl]acetic acid and their analgesic and anti-inflammatory properties. Arz Forsch Drug Res, 55, pp. 520-527.
15. Süküroǧlu, M., Çaliskan-Ergun, B., Ünlü, S., Sahin, MF, Küpeli, E., Yesilada, E., Banoǧlu, E. and Akoǧlu, C. (2005) Synthesis, analgesic and anti-inflammatory activities of [6-(3,5-dimethyl-4-pyrazol-1-yl)-3(2H)-pyrazinone-2-yl]acetamides. Arch Pharm Res, 28, pp. 509-517.
16. Süküroǧlu, M., Çalişkan-Ergün, B., Das-Evcimen, N., Sarikaya, M., Banoǧlu, E. and Suzen, S. (2007) Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives. Med Chem Res
17. McCord, J. and Fridowich, I. (1969) An enzymic function for erythrocuprein. J Biol Chem, 243, pp. 6049-6055.
18. 4 intoxication, and vitamin E deficiency. Biochem Med, 23, pp. 303-311.
19. Blois, MS (1958) Antioxidant determination by the use of stable free radical. Nature, 181, pp. 1199-1200.
20. Halliwell, B. (1994) Free radicals and antioxidants: A personal view. Nutrition Rev, 52, pp. 253-265.