Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle

Stem Cells

Volumn 26, Issue 2, 2008, Pages 445-454

  Dong, Wook Han ^a,b   Do, Jeong Tae ^a   Gentile, Luca ^a   Stehling, Martin ^a   Hoon, Taek Lee ^b   Schöler, Hans R ^a  

^a MAX PLANCK INSTITUTE FOR MOLECULAR BIOMEDICINE   (Germany)

^b Konkuk University   (South Korea)

Author keywords

Cell cycle; DNA methylation; Fusion; Oct4; Reprogramming

Indexed keywords

GREEN FLUORESCENT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR NANOG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CELL FUSION; CONTROLLED STUDY; DEMETHYLATION; EMBRYO; EMBRYONIC STEM CELL; ENHANCER REGION; FEMALE; GENE ACTIVATION; GENOME; HYBRID CELL; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; SOMATIC CELL; SOMATIC CELL GENETICS; TRANSGENE;

EID: 40949102668     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2007-0553     Document Type: Article

References (28)

1. Campbell KH, McWhir J, Ritchie WA et al. Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996;380:64-66.
2. Do JT, Scholer HR. Cell-cell fusion as a means to establish pluripotency. Ernst Schering Res Found Workshop 2006:35-45.
3. Hall VJ, Stojkovic P, Stojkovic M. Using therapeutic cloning to fight human disease: A conundrum or reality? STEM CELLS 2006;24:1628-1637.
4. Boiani M, Eckardt S, Scholer HR et al. Oct4 distribution and level in mouse clones: Consequences for pluripotency. Genes Dev 2002;16:1209-1219.
5. Do JT, Scholer HR. Nuclei of embryonic stem cells reprogram somatic cells. STEM CELLS 2004;22:941-949.
6. Tada M, Tada T, Lefebvre L et al. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J 1997;16:6510-6520.
7. Tada M, Takahama Y, Abe K et al. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol 2001;11:1553-1558.
8. Nichols J, Zevnik B, Anastassiadis K et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-391.
9. Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000;24:372-376.
10. Yeom YI, Fuhrmann G, Ovitt CE et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 1996;122:881-894.
11. Ying QL, Nichols J, Evans EP et al. Changing potency by spontaneous fusion. Nature 2002;416:545-548.
12. Silva J, Chambers I, Pollard S et al. Nanog promotes transfer of pluripotency after cell fusion. Nature 2006;441:997-1001.
13. Hochedlinger K, Jaenisch R. Nuclear reprogramming and pluripotency. Nature 2006;441:1061-1067.
14. Araujo FD, Knox JD, Szyf M et al. Concurrent replication and methylation at mammalian origins of replication. Mol Cell Biol 1998;18:3475-3482.
15. Knox JD, Araujo FD, Bigey P et al. Inhibition of DNA methyltransferase inhibits DNA replication. J Biol Chem 2000;275:17986-17990.
16. Rein T, Kobayashi T, Malott M et al. DNA methylation at mammalian replication origins. J Biol Chem 1999;274:25792-25800.
17. Tae Do J, Han DW, Gentile L et al. Erasure of cellular memory by fusion with pluripotent cells. STEM CELLS 2007;25:1013-1020.
18. Boiani M, Gentile L, Gambles VV et al. Variable reprogramming of the pluripotent stem cell marker Oct4 in mouse clones: Distinct developmental potentials in different culture environments. STEM CELLS 2005;23:1089 -1104.
19. Yamazaki T, Yamagata K, Baba T. Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging. Dev Biol 2007;304:409-419.
20. Yamazaki Y, Fujita TC, Low EW et al. Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos. Mol Reprod Dev 2006;73:180-188.
21. Marikawa Y, Fujita TC, Alarcon VB. Heterogeneous DNA methylation status of the regulatory element of the mouse Oct4 gene in adult somatic cell population. Cloning Stem Cells 2005;7:8-16.
22. Okazawa H, Okamoto K, Ishino F et al. The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. EMBO J 1991;10:2997-3005.
23. Sullivan S, Pells S, Hooper M et al. Nuclear reprogramming of somatic cells by embryonic stem cells is affected by cell cycle stage. Cloning Stem Cells 2006;8:174-188.
24. Ovitt CE, Scholer HR. The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod 1998;4:1021-1031.
25. Hattori N, Nishino K, Ko YG et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem 2004;279:17063-17069.
26. Labosky PA, Barlow DP, Hogan BL. Mouse embryonic germ (EG) cell lines: Transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem (ES) cell lines. Development 1994;120:3197-3204.
27. Tada T, Tada M, Hilton K et al. Epigenotype switching of imprintable loci in embryonic germ cells. Dev Genes Evol 1998;207:551-561.
28. Gidekel S, Bergman Y. A unique developmental pattern of Oct4-3/4 DNA methylation is controlled by a cis-demodification element. J Biol Chem 2002;277:34521-34530.