Deoxygenated phosphorothioate inositol phosphate analogs: Synthesis, phosphatase stability, and binding affinity

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 3419-3427

  Liu, Xiaodan ^a   Moody, Emily C ^b   Hecht, Stephen S ^a,b   Sturla, Shana J ^a,b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Binding affinity; Ins(1,4,5)P3 analog; Ins(1,4,5)P3 receptor; Myo inositol 1,4,5 trisphosphate; Phosphatase stable analogs

Indexed keywords

1D 1,2,3 TRIDEOXY MYO INOSITOL 4,5 BISPHOSPHOROTHIOATE; 1D 2,3 DIDEOXY MYO INOSITOL 1,4,5 TRISPHOSPHOROTHIOATE; ALKALINE PHOSPHATASE; CYCLOHEXANE; HYDROXYL GROUP; INOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR; PHOSPHATASE; PHOSPHOROTHIOIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DEPHOSPHORYLATION; DRUG SYNTHESIS; ENZYME STABILITY; HYDROLYSIS; PHOSPHORYLATION;

ALKALINE PHOSPHATASE; ANIMALS; DRUG STABILITY; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; INOSITOL PHOSPHATES; PHOSPHATES; PROTEIN BINDING;

EID: 40949093101     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.032     Document Type: Article

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