Corneal rat-to-mouse xenotransplantation and the effects of anti-CD4 or anti-CD8 treatment on cytokine and nitric oxide production

Transplant International

Volumn 18, Issue 7, 2005, Pages 854-862

  Pindjáková, Jana ^a   Vitová, Andrea ^a   Krulová, Magdaléna ^a   Zajíková, Alena ^a   Filipec, Martin ^b   Holáň, Vladimír ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Anti CD4 treatment; Corneal xenotransplantation; Cytokines; Graft survival; Nitric oxide

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; NITRIC OXIDE; OKT 4; OKT 8; CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; NITRIC OXIDE SYNTHASE; NOS2 PROTEIN, MOUSE; NOS2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORNEA TRANSPLANTATION; DRUG INHIBITION; GENE CONTROL; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOFLUORESCENCE; ISOGRAFT; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL; TH2 CELL; UPREGULATION; XENOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CORNEA; DRUG EFFECT; FEMALE; GENETICS; IMMUNOLOGY; LEWIS RAT; MALE; METABOLISM; RAT; XENOGRAFT;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; ANTIGENS, CD8; CORNEA; CORNEAL TRANSPLANTATION; CYTOKINES; FEMALE; GENE EXPRESSION; GRAFT SURVIVAL; MALE; MICE; MICE, INBRED BALB C; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, INBRED LEW; TRANSPLANTATION, HETEROLOGOUS;

EID: 26044454592     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/j.1432-2277.2005.00112.x     Document Type: Article

References (41)

1. Williams K, Muehlberg SM, Lewis RF, Coster DJ. How successful is corneal transplantation? A report from the Australian Corneal Graft Register. Eye 1995; 9: 219.
2. The collaborative corneal transplantation studies (CCTS): effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group. Arch Ophthalmol 1992; 110: 1392.
3. Ross JR, Howell DN, Sanfilippo FP. Characteristics of corneal xenograft rejection in a discordant species combination. Invest Ophthalmol Vis Sci 1993; 34: 2469.
4. Larkin DFP, Takano T, Stansfield SD, Williams KA. Experimental orthotopic corneal xenotransplantation in the rat. Mechanisms of graft rejection. Transplantation 1995; 60: 491.
5. Higuchi R, Streilein JW. CD8+ T cell-mediated delayed rejection of orthotopic guinea pig cornea grafts in mice deficient in CD4+ T cells. Invest Ophthalmol Vis Sci 2003; 44: 175.
6. Sonoda Y, Streilein JW. Orthotopic corneal transplantation in mice - evidence that immunogenetic rules of rejection do not apply. Transplantation 1992; 54: 694.
7. Holáň V, Hašková; Z, Filipec M. Transplantation immunity and tolerance in the eye. Rejection and acceptance of orthotopic corneal allografts in mice. Transplantation 1996; 62: 1050.
8. Yamamoto M, Einaga-Naito K, Kariyama M, Kawada Y, Yoshida R. Cellular basis of skin allograft rejection in mice: specific lysis of allogeneic skin components by non-T cells. Transplantation 1998; 65: 818.
9. Larkin DFP, Calder VL, Lightman SL. Identification and characterization of cells infiltrating the graft and aqueous humor in rat corneal allograft rejection. Clin Exp Immunol 1997; 107: 381.
10. Kuffová L, Holáň V, Lumsden L, Forrester JV, Filipec M. Cell subpopulations in failed human corneal grafts. Br J Ophthalmol 1999; 83: 1364.
11. King WJ, Comer RM, Hudde T, Larkin DFP, George AJT. Cytokine and chemokine expression kinetics after corneal transplantation. Transplantation 2000; 70: 1225.
12. Torres PF, de Vos AF, Van der Gaag R, Martins B, Kijlstra A. Cytokine mRNA expression during experimental corneal allograft rejection. Exp Eye Res 1996; 63: 453.
13. She SC, Steahly LP, Moticka EJ. A method for performing full-thickness, orthotopic, penetrating keratoplasty in the mouse. Ophthalmic Surg 1990; 21: 781.
14. Plšková J, Kuffová L, Holáň V, Filipec M, Forrester JV. Evaluation of corneal graft rejection in a mouse model. Br J Ophthalmol 2002; 86: 108.
15. Dialynas DP, Wilde DB, Marrack P, et al. Characterization of the murine antigenic determinant designed L3T4a, recognized by monoclonal antibody GK1.5: expression of L3T4a by functional T-cell clones appears to correlate primarily with class II MHC antigen-reactivity. Immunol Rev 1983; 74: 29.
16. Gottlieb PD, Marshak-Rothstein A, Auditore-Hargreaves K, et al. Construction and properties of new Lyt-congeneic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies, Immunogenetics 1980; 10: 545.
17. + T cells. J Immunol 1998; 161: 3237.
18. Holáň V, Sedláčková K, Růžičková M. Production of high levels of Th1 and Th2 cytokines in mice with acquired transplantation tolerance. Cell Immunol 1996; 174: 7.
19. 15N] nitrate in biological fluids. Anal Biochem 1982; 126: 131.
20. Brouard S, Gagne K, Blancho G, Soulillou JP. T cell response in xenorecognition and xenografts: a review. Human Immunol 1999; 60: 455.
21. Deol HS, Tuch BE. Effect of interleukin-10 on human anti-porcine xenogeneic cellular response in vitro. Transplantation 2000; 69: 112.
22. Lorant T, Krook H, Wilton J, et al. Intragraft cytokine mRNA expression in rejecting and non-rejecting vascularized xenografts. Xenotransplantation 2003; 10: 311.
23. Singh NP, Guo L, Mhoyan A, Shirwan H. Predominant expression of Th2 cytokines and interferon-gamma in xenogeneic cardiac grafts undergoing acute vascular rejection. Transplantation 2003; 75: 586.
24. Deng S, Ketchum RJ, Kucher M, et al. IL-10 and TGF-beta gene transfer for xenogeneic islet transplantation: comparison of effect in concordant vs. discordant combination. Transplant Proc 1997; 29: 2204.
25. + or B lymphocytes, can reject xenogeneic skin grafts. Xenotransplantation 1994; 1: 8.
26. + cells in the rejection of highly disparate xenogeneic pig thymus grafts. Xenotransplantation 2000; 7: 129.
27. Tanaka K, Yamada J, Streilein JW. Xenoreactive CD4+ T cells and acute rejection of orthotopic guinea pig corneas in mice. Invest Ophthalmol Vis Sci 2000; 41: 1827.
28. Singh NP, Guo L, Que X, Shirwan H. Blockade of indirect recognition mediated by CD4+ T cell leads to prolonged cardiac xenograft survival. Xenotransplantation 2004; 11: 33.
29. Yi S, Feng X, Hawthorne W, Patel A, Walters S, O'Connell PJ. CD8+ T cells are capable of rejecting pancreatic islet xenografts. Transplantation 2000; 70: 896.
30. Tanemura M, Chong AS, DiSesa VJ, Galili U. Direct killing of xenograft cells by CD8+ T cells of discordant xenograft recipients. Transplantation 2002; 74: 1587.
31. Candinas D, Belliveaut S, Koyamada N, et al. T cell independence of macrophage and natural killer cell infiltration, cytokine production, and endothelial activation during delayed xenograft rejection. Transplantation 1996; 62: 1920.
32. Brüne B, von Knethen A, Sandau KB. Nitric oxide and its role in apoptosis. Eur J Pharmacol 1998; 351: 261.
33. Yanagiya N, Akiba J, Kado M, Yoshida A, Kono T, Iwamoto J. Transient corneal edema induced by nitric oxide synthase inhibition. Nitric Oxide 1997; 1: 397.
34. Jeng BH, Meisler DM, Hollyfield JG, Aulak KS, Stuehr DJ. Immimohistochemical localization of eNOS, iNOS, bNOS, and peroxynitrite in stored human corneas. Invest Ophthalmol Vis Sci 2002; 43: 138.
35. Hibbs JBJ, Taintor RR, Vavrin Z, Rachlin M. Nitric oxide: a cytotoxic-activated macrophage effector molecule. Biochem Biophys Res Commun 1988; 157: 87.
36. Wu G, Korsgren O, van Rooijen N, Wennberg L, Tibell A. The effect of macrophage depletion on delayed xenograft rejection: studies in the guinea pig-to-C6-deficient rat heart transplantation model. Xenotransplantation 1999; 6: 262.
37. Wallgren AC, Karlsson-Parra A, Korsgren O. The main infiltrating cell in xenograft rejection is a CD4+ macrophage and not a T lymphocyte. Transplantation 1995; 60: 594.
38. Yi S, Hawthorne WJ, Lehnert AM, et al. T cell-mediated macrophages are capable of both recognition and rejection of pancreatic islet xenografts. J Immunol 2003; 170: 2750.
39. Streštíková P, Plšková J, Filipec M, Farghali H. FK 506 and aminoguanidine suppress iNOS induction in orthotopic corneal allografts and prolong graft survival in mice. Nitric Oxide 2003; 9: 111.
40. Slegers TP, van der Gaag R, van Rooijen N, van Rij G, Streilein JW. Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts. Curr Eye Res 2003; 26: 73.
41. Kim JY, Kim D, Lee EM, et al. Inducible nitric oxide synthase inhibitors prolonged the survival of skin xenografts through selective down-regulation of pro-inflammatory cytokine and CC-chemokine expressions. Transpl Immunol 2003; 12: 63.