Thionamides inhibit the transcription factor nuclear factor-κB by suppression of Rac1 and inhibitor of κB kinase α

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 3, 2008, Pages 1037-1044

  Humar, Matjaz ^a,d   Dohrmann, Hannah ^a   Stein, Philipp ^a   Andriopoulos, Nikolaos ^b   Goebel, Ulrich ^a   Roesslein, Martin ^a   Schmidt, Rene ^a   Schwer, Christian I ^a   Loop, Torsten ^a   Geiger, Klaus K ^a   Pahl, Heike L ^a   Pannen, Benedikt H J ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^d Center for Clinical Research   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIMAZOLE; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROPYLTHIOURACIL; RAC1 PROTEIN; THIAMAZOLE; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; T LYMPHOCYTE;

ANTITHYROID AGENTS; HUMANS; I-KAPPA B KINASE; JURKAT CELLS; LEUKOCYTES, MONONUCLEAR; NF-KAPPA B; RAC1 GTP-BINDING PROTEIN; SULFHYDRYL COMPOUNDS;

EID: 40849147275     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.132407     Document Type: Article

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