Spontaneous autoimmune disease in (NZB x NZW)F1 mice is ameliorated by treatment with methimazole

Journal of Clinical Immunology

Volumn 18, Issue 2, 1998, Pages 106-113

  Mozes, Edna ^a,b   Zinger, Heidy ^b   Kohn, Leonard D ^c   Singer, Dinah S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Autoimmunity; Lupus; Methimazole; MHC class 1

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PLACEBO; THIAMAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CONTROLLED STUDY; FEMALE; IMMUNE COMPLEX DEPOSITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; SUBCUTANEOUS DRUG ADMINISTRATION; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

AGING; ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; DNA; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS I; LUPUS ERYTHEMATOSUS, SYSTEMIC; METHIMAZOLE; MICE; MICE, INBRED BALB C; MICE, INBRED NZB;

EID: 0031887609     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023242732212     Document Type: Article

References (24)

1. Talal N: Autoimmunity: Genetic Immunology, Virology and Clinical Aspects. New York, Academic Press, 1977
2. Kohn LD, Kosugi S, Ban T, Saji M, Ikuyamu S, Giulani C, Hidaka A, Shimura H, Akamizu T, Tahara K, Moriarty J, Prabhakar BS, Singer DS: Molecular basis for the autoreactivity against thyroid stimulating hormone receptor. Im Rev Immunol 9:135-165, 1992
3. Theofilopoulos AN, Dixon F: Murine models of systemic lupus erythematosus. Adv Immunol 73:269-390, 1985
4. Mendlovic S, Brocke S, Shoenfeld Y, Ben-Bassat M, Meshorer A, Bakimer R, Mozes E: Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype. Proc Natl Acad Sci USA 85:2260-2264, 1988
5. Mozes B, Kohn LD, Hakim F, Singer DS: Resistance of MHC class I-deficient mice to experimental systemic lupus erythematosus. Science 261:91-93, 1993
6. Chan C, Gery I, Kohn LD, Nussenblatt R, Mozes E, Singer DS: Periocular inflammation in mice with experimental systemic lupus erythematosus. J Immunol 154:4830-4835, 1995
7. Singer DS, Kohn LD, Zinger H, Mozes E: Methimazole prevents induction of experimental systemic lupus erythematosus in mice. J Immunol 153:873-880, 1994
8. Saji M, Moriarty J, Ban T, Singer DS, Kohn LD: MHC Class I expression in rat thyroid cells is regulated by hormones, methimazole, and iodide, as well as interferon. J Clin Endocrinol Metab 75:871-878, 1992
9. Cooper DS: Antithyroid drugs. N Engl J Med 311:1353, 1984
10. Solomon DH: Treatment of Graves' hyperthyroidism. In The Thyroid, SH Ingbar, LE Braverman (eds). Philadelphia, PA. J. B. Lippincott, 1986, p 987
11. Mozes E, Mendlovic S: The role of anti-DNA idiotype antibodies in systemic lupus erythematosus. Crit Rev Immunol 10:329-345, 1990
12. Takahashi S, Nose M, Sasaki J, Yamamoto T, Koyogoku M: IgG3 production in MRL/lpr mice is responsible for development of lupus nephritis. J Immunol 147:515-519, 1991
13. Erausquin C, Merino R, Izui S, Fernandez-Sueiro L, Saez F, Fernandez, Rodriguez-Valverde V, Merino J: Therapeutic efect of early thymic irradiation in (NZB × NZW)F1 mice associated with a selective decrease in the level of IgG3 and gp-70 anti-gp70 immune complexes. Cell Immunol 161:207-212, 1995
14. Sthoeger Z, Bentwich A, Zinger H, Mozes E: The beneficial effect of the estrogen antagonist, tamoxifen, on experimental systemic lupus erythematosus. J Rheumatol 21:2231-2238, 1994
15. Segal R, Dayan M, Zinger H, Mozes E: Methotrexate treatment in experimental SLE: Clinical benefits associated with cytokine manipulation. Clin Exp Immunol 101:66-72, 1995
16. Dayan M, Zinger H, Kalush F, Mor G, Amir-Zaltzman Y, Kohen F, Sthoeger Z, Mozes E: The beneficial effects of treatment with tamoxifen and anti-oestradiol antibody on experimental SLE are associated with cytokine modulation. Immunology 90:101-108, 1997
17. Mixter P, Russell J, Durie F, Budd R: Decreased CD4-CD8-TCR-αβ+ cells in lpr/lpr mice lacking β2 microglobulin. J Immunol 154:2063-2074, 1995
18. Montani V, Taniguchi S, Guiliani C, Napolitano G, Singer DS, Kohn LD: Regulation of major histocompatibility (MHC) complex class II gene expression in thyroid cells. In Program and Abstracts of the 10th International Congress of Endocrinology, 1996, Vol 1, p 43
19. Sidman C, Luther E, Marshall J, Nguyen K, Roopenian D, Worthen S: Increased expression of major histocompatibility complex antigens on lymphocytes from aged mice. Proc Natl Acad Sci USA 84:7624-7628, 1987
20. Taurog J, Maika S, Simmons W, Breban M, Hammer R: Susceptibility to inflammatory disease in HLA-B27 expression. J Immunol 150:4168-4178, 1993
21. 2-Microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43:500-504, 1994
22. Wofsy D, Seaman W: Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med 161:378-391, 1985
23. Finck B, Linsley P, Wofsy D: Treatment of murine lupus with CTLA41g. Science 265:1225-1227, 1994
24. Wang Y, Hu Q, Madri J, Rollins S, Chodera A, Matis L: Amelioration of lupus-like autoimmune disease in NZB × W F1 mice after treatment with a blocking monoclonal antibody specific for complement component, C5. Proc Natl Acad Sci USA 93: 8563-8568, 1996