Fast gas chromatography-negative-ion chemical ionization mass spectrometry with microscale volume sample preparation for the determination of benzodiazepines and α-hydroxy metabolites, zaleplon and zopiclone in whole blood

Journal of Mass Spectrometry

Volumn 41, Issue 6, 2006, Pages 741-754

  Gunnar, Teemu ^a   Ariniemi, Kari ^a   Lillsunde, Pirjo ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Benzodiazepines; Fast gas chromatography mass spectrometry; Hypnotic agents; Negative ion chemical ionization; Whole blood

Indexed keywords

BENZENE; BIOASSAY; BLOOD; DATA ACQUISITION; GAS CHROMATOGRAPHY; IONIZATION; METABOLITES;

BENZODIAZEPINES; FAST GAS CHROMATOGRAPHY/MASS SPECTROMETRY; HYPNOTIC AGENTS; NEGATIVE-ION CHEMICAL IONIZATION; WHOLE BLOOD;

MASS SPECTROMETRY;

ACETAMIDE DERIVATIVE; ALPHA HYDROXYMIDAZOLAM; ALPRAZOLAM; ANION; BENZODIAZEPINE DERIVATIVE; BROMAZEPAM; CHLORDIAZEPOXIDE; CLONAZEPAM; DIAZEPAM; FLUNITRAZEPAM; HYDROGEN; LORAZEPAM; MIDAZOLAM; N METHYL N (TERT BUTYLDIMETHYLSILYL)TRIFLUOROACETAMIDE; NITRAZEPAM; NORDAZEPAM; OXAZEPAM; PHENAZEPAM; TEMAZEPAM; TRIAZOLAM; UNCLASSIFIED DRUG; ZALEPLON; ZOPICLONE;

ANALYTIC METHOD; ARTICLE; ASSAY; BLOOD SAMPLING; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEUTERIUM HYDROGEN EXCHANGE; DRUG DETERMINATION; DRUG SCREENING; FLOW RATE; FORENSIC PATHOLOGY; GAS; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; SILYLATION; TEMPERATURE DEPENDENCE; VALIDATION PROCESS;

ACETAMIDES; BENZODIAZEPINES; BLOOD CHEMICAL ANALYSIS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MICROCHEMISTRY; PIPERAZINES; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECIMEN HANDLING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TIME FACTORS;

EID: 33745792744     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1030     Document Type: Article

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