A method for screening for various sedative-hypnotics in serum by liquid chromatography/single quadrupole mass spectrometry

Forensic Science International

Volumn 157, Issue 1, 2006, Pages 57-70

  Miyaguchi, Hajime ^a   Kuwayama, Kenji ^a   Tsujikawa, Kenji ^a   Kanamori, Tatsuyuki ^a   Iwata, Yuko T ^a   Inoue, Hiroyuki ^a   Kishi, Tohru ^a  

^a NATIONAL RESEARCH INSTITUTE OF POLICE SCIENCE   (Japan)

Author keywords

Benzodiazepines; Drug screening; Liquid chromatography mass spectrometry (LC MS); Serum; Solid phase extraction

Indexed keywords

APRONAL; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE; BROMISOVAL; CHLORAL HYDRATE; CHLORPROMAZINE; DIPHENHYDRAMINE; HYDROXYZINE; HYPNOTIC SEDATIVE AGENT; PROMETHAZINE; TANDOSPIRONE; TRICLOFOS; ZOLPIDEM; ZOPICLONE;

ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SCREENING; SOLID PHASE EXTRACTION;

EID: 30944443337     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2005.03.011     Document Type: Article

References (37)

1. O.H. Drummer Methods for the measurement of benzodiazepines in biological samples J. Chromatogr. B 713 1998 201 225
2. H. Inoue, Y. Maeno, M. Iwasa, R. Matoba, and M. Nagao Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry Forensic Sci. Int. 113 2000 367 373
3. D. Borrey, E. Meyer, W. Lambert, S. Van Calenbergh, C. Van Peteghem, and A.P. De Leenheer Sensitive gas chromatographic-mass spectrometric screening of acetylated benzodiazepines J. Chromatogr. A 910 2001 105 118
4. C.B. Eap, G. Bouchoux, K. Powell Golay, and P. Baumann Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry J. Chromatogr. B 802 2004 339 345
5. M. Rittner, F. Pragst, W.-R. Bork, and J. Neumann Screening method for seventy psychoactive drugs or drug metabolites in serum based on high-performance liquid chromatography-electrospray ionization mass spectrometry J. Anal. Toxicol. 25 2001 115 124
6. N. Venisse, P. Marquet, E. Duchoslav, J.L. Dupuy, and G. Lachâtre A general unknown screening procedure for drugs and toxic compounds in serum using liquid chromatography-electrospray-single quadrupole mass spectrometry J. Anal. Toxicol. 27 2003 7 14
7. M. Gergov, I. Ojanperä, and E. Vuori Simultaneous screening for 238 drugs in blood by liquid chromatography-ionspray tandem mass spectrometry with multiple-reaction monitoring J. Chromatogr. B 795 2003 41 53
8. C. Kratzsch, O. Tenberken, F.T. Peters, A.A. Weber, T. Kraemer, and H.H. Maurer Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization J. Mass Spectrom. 39 2004 856 872
9. B.E. Smink, J.E. Brandsma, A. Dijkhuizen, K.J. Lusthof, J.J. de Gier, A.C. Egberts, and D.R.A. Uges Quantitative analysis of 33 benzodiazepines, metabolites and benzodiazepine-like substances in whole blood by liquid chromatography-(tandem) mass spectrometry J. Chromatogr. B 811 2004 13 20
10. P. Marquet Is LC-MS suitable for a comprehensive screening of drugs and poisons in clinical toxicology? Ther. Drug Monit. 24 2002 125 133
11. Y. Ohmae, T. Kanamori, Y. Iwata, K. Tsujikawa, K. Kuwayama, H. Inoue, and T. Kishi Study on mixed-mode solid-phase extraction for drug screening in human serum Jpn. J. Sci. Technol. Iden. 9 2004 71 78 (abstract in English)
12. Japan Pharmaceutical Information Center (Ed.), Drugs in Japan: Ethical Drugs, 28th ed., Jiho, Tokyo, 2004 (in Japanese).
13. Japan Pharmaceutical Information Center (Ed.), Drugs in Japan: OTC-Drugs, 14th ed., Jiho, Tokyo, 2003 (in Japanese).
14. L.H. Sternbach, R.I. Fryer, W. Metlesics, E. Reeder, G. Sach, G. Saucy, and A. Stempel Quinazolines and 1,4-benzodiazepines. VI. Halo-, methyl-, and methoxy-substituted 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-ones J. Org. Chem. 27 1962 3788 3796
15. Y. Adachi, and T. Takahashi Forensic identification of drugs and toxic substances by liquid chromatography-electrospray ionization/mass spectrometry J. Mass Spectrom. Soc. Jpn. 52 2004 39 44 (abstract in English)
16. R. Bonfiglio, R.C. King, T.V. Olah, and K. Merkle The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds Rapid Commun. Mass Spectrom. 13 1999 1175 1185
17. D.K.J. Gorecki, K.W. Hindmarsh, C.A. Hall, and D.J. Mayers Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration J. Chromatogr. 528 1990 333 341
18. E.M. Sellers, M. Lang-Sellers, and J. Koch-Weser Comparative metabolism of chloral hydrate and triclofos J. Clin. Pharmacol. 18 1978 457 461
19. D. Lavene, C. Abriol, M. Guerret, J.R. Kiechel, A. Lallemand, and R. Rulliere Pharmacokinetics of cloxazolam in man, after single and multiple oral doses Thérapie 35 1980 533 543
20. H. Shindo, R. Hayashi, T. Ariga, and J. Totsu Pharmacokinetics and urinary metabolites of haloxazolam (CS-430) in man (author's translation) Yakuri To Chiryo 8 1980 4551 4567 (in Japanese)
21. Y. Higa, and R. Watanabe Clinical pharmacological study of anxiolytic drug CS-386 (author's translation) Shinryo To Shinyaku 16 1979 984 1000 (in Japanese)
22. Y. Yamazaki, T. Iwai, T. Ninomiya, and Y. Kawahara Pharmacokinetics in man following oral administration of oxazolam Ann. Rep. Sankyo Res. Lab. 32 1980 104 113
23. T. Kobari, H. Namekawa, and A. Ujiie Pharmacokinetics of MS-4101 in man (author's translation) Yakuri To Chiryo 6 1978 1679 1688 (in Japanese)
24. T. Yamaguchi, M. Nakanishi, M. Yamashita, H. Matsumoto, M. Nakamura, G. Kominami, K. Iwatani, Y. Nakagawa, M. Kono, K. Sugeno, and H. Fukuda Pharmacology of a new sleep-inducer, 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (VIII). Examination and determination of metabolites in human plasma and urine Folia Pharmacol. Jpn. 90 1987 239 247 (abstract in English)
25. H. Davi, J. Guyonnet, Y. Sales, and W. Cautreels Metabolism of ethyl loflazepate in the rat, the dog, the baboon and in man Arzneim. Forsch. 35 1985 1061 1065
26. M. Hasegawa, and I. Matsubara Metabolic fates of flurazepam. I. Gas chromatographic determination of flurazepam and its metabolites in human urine and blood using electron capture detector Chem. Pharm. Bull. (Tokyo) 23 1975 1826 1833
27. N. Barzaghi, L. Leone, M. Monteleone, G. Tomasini, and E. Perucca Pharmacokinetics of flutoprazepam, a novel benzodiazepine drug, in normal subjects Eur. J. Drug Metab. Pharmacokinet. 14 1989 293 298
28. Interview Form (Manufacturer's Brochure) of Erispan, Sumitomo Pharmaceuticals, Osaka, Japan, 1998 (in Japanese)
29. 14C-quazepam in man Drug Metab. Dispos. 13 1985 25 29
30. R.I. Shader, R.J. Pary, J.S. Harmatz, S. Allison, A. Locniskar, and D.J. Greenblatt Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam J. Clin. Psychiatry 45 1984 411 413
31. H.R. Ochs, D.J. Greenblatt, B. Verburg-Ochs, and A. Locniskar Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam J. Clin. Pharmacol. 24 1984 446 451
32. M. Viukari, and M. Linnoila Serum medazepam, diazepam, and N-desmethyldiazepam levels after single and multiple oral doses of medazepam Ann. Clin. Res. 9 1977 284 286
33. R. Dixon, M.A. Brooks, E. Postma, M.R. Hackman, S. Spector, J.D. Moore, and M.A. Schwartz N-Desmethyldiazepam: a new metabolite of chlordiazepoxide in man Clin. Pharmacol. Ther. 20 1976 450 457
34. 14C Eur. J. Drug Metab. Pharmacokinet. 4 1979 237 243
35. R.I. Shader, D.J. Greenblatt, J.S. Harmatz, K. Franke, and J. Koch-Weser Absorption and disposition of chlordiazepoxide in young and elderly male volunteers J. Clin. Pharmacol. 17 1977 709 718
36. Y. Yanagi, F. Haga, M. Endo, and S. Kitagawa Comparative metabolic study of nimetazepam and its desmethyl derivative (nitrazepam) in dogs Xenobiotica 6 1976 101 112
37. K.T. Nguyen, D.P. Stephens, M.J. McLeish, D.P. Crankshaw, and D.J. Morgan Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental Anesth. Analg. 83 1996 552 558