Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 6, 2008, Pages 1864-1868

  Lai, Gaifa ^a   Merritt, J Robert ^a   He, Zhenmin ^a   Feng, Daming ^a   Chao, Jianhua ^b   Czarniecki, Michael F ^b   Rokosz, Laura L ^a   Stauffer, Tara M ^a   Rindgen, Diane ^b   Taveras, Arthur G ^b  

^a PHARMACOPEIA INC   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antagonists; CXCR2 receptor; Cyclobutenediones; Structure activity relationships; Synthesis

Indexed keywords

3,4 DIAMINO 3 CYCLOBUTENE 1,2 DIONE DERIVATIVE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOBUTANES; HAPLORHINI; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; RECEPTORS, INTERLEUKIN-8B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40849126299     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.010     Document Type: Article

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