The critical role of human transcriptional repressor CTCF mRNA up-regulation in the induction of anti-HIV-1 responses in CD4+ T cells

Immunology Letters

Volumn 117, Issue 1, 2008, Pages 35-44

  Li, Yuchang ^a   Li, Guanhua ^a   Ivanova, Anna ^a   Aaron, Sagiv ^a   Simm, Malgorzata ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

CD4; CTCF; HIV 1; Resistance; T cell

Indexed keywords

DNA BINDING PROTEIN; PROTEIN CTCF; UNCLASSIFIED DRUG;

ANTIBODY RESPONSE; ARTICLE; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; DNA-BINDING PROTEINS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MACROPHAGES; PROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; UP-REGULATION;

EID: 40849116658     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.11.017     Document Type: Article

References (32)

1. Klenova E.M., Morse H.C.F., Ohlsson R., and Lobanenkov VV. The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer. Semin Cancer Biol 12 (2002) 399-414
2. Ohlsson R., Renkawitz R., and Lobanenkov V. CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet 17 (2001) 520-527
3. Dunn K.L., and Davie J.R. The many roles of the transcriptional regulator CTCF. Biochem Cell Biol 81 (2003) 161-167
4. Lutz M., Burke L.J., LeFevre P., Myers F.A., Thorne A.W., Crane-Robinson C., et al. Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor. Embo J 22 (2003) 1579-1587
5. Filippova G.N., Fagerlie S., Klenova E.M., Myers C., Dehner Y., Goodwin G., et al. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol 16 (1996) 2802-2813
6. Klenova E.M., Nicolas R.H., Paterson H.F., Carne A.F., Heath C.M., Goodwin G.H., et al. CTCF, a conserved nuclear factor required for optimal transcriptional activity of the chicken c-myc gene, is an 11-Zn-finger protein differentially expressed in multiple forms. Mol Cell Biol 13 (1993) 7612-7624
7. Klenova E.M., Nicolas R.H., U S., Carne A.F., Lee R.E., Lobanenkov V.V., et al. Molecular weight abnormalities of the CTCF transcription factor: CTCF migrates aberrantly in SDS-PAGE and the size of the expressed protein is affected by the UTRs and sequences within the coding region of the CTCF gene. Nucleic Acids Res 25 (1997) 466-474
8. Kartvelishvili A., Lesner A., Szponar M., and Simm M. Microarray analysis of differentially expressed genes in cells resistant to HIV-1. Immunol Lett 93 (2004) 79-86
9. Lesner A., Kartvelishvili A., Lesniak J., Nikolov D., Kartvelishvili M., Trillo-Pazos G., et al. Monoubiquitinated histone H1B is required for antiviral protection in CD4(+)T cells resistant to HIV-1. Biochemistry 43 (2004) 16203-16211
10. Lesner A., Li Y., Nitkiewicz J., Li G., Kartvelishvili A., Kartvelishvili M., et al. A soluble factor secreted by an HIV-1-resistant cell line blocks transcription through inactivating the DNA-binding capacity of the NF-kappa B p65/p50 dimer. J Immunol 175 (2005) 2548-2554
11. Simm M., Miller L.S., Durkin H.G., Allen M., Chao W., Lesner A., et al. Induction of secreted human immunodeficiency virus type 1 (HIV-1) resistance factors in CD4-positive T lymphocytes by attenuated HIV-1 infection. Virology 294 (2002) 1-12
12. Simm M., Pekarskaya O., Potash M.J., and Volsky D.J. Prolonged infection of peripheral blood lymphocytes by Vif-negative HIV type 1 induces resistance to productive HIV type 1 infection through soluble factors. AIDS Research and Human Retroviruses 16 (2000) 943-952
13. Drueppel L., Pfleiderer K., Schmidt A., Hillen W., and Berens C. A short autonomous repression motif is located within the N-terminal domain of CTCF. FEBS Lett 572 (2004) 154-158
14. Simm M., Su Z., Huang E.Y., Chen Y., Jiang H., Volsky D.J., et al. Cloning of differentially expressed genes in an HIV-1 resistant T cell clone by rapid subtraction hybridisation, RaSH. Gene 269 (2001) 93-101
15. Su Z.Z., Chen Y., Kang D.C., Chao W., Simm M., Volsky D.J., et al. Customized rapid subtraction hybridization (RaSH) gene microarrays identify overlapping expression changes in human fetal astrocytes resulting from human immunodeficiency virus-1 infection or tumor necrosis factor-alpha treatment. Gene 306 (2003) 67-78
16. Aguilar-Cordova E., Chinen J., Donehower L., Lewis D.E., and Belmont J.W. A sensitive reporter cell line for HIV-1 tat activity, HIV-1 inhibitors, and T cell activation effects. AIDS Research and Human Retroviruses 10 (1994) 295-301
17. Choe W., Volsky D.J., and Potash M.J. Induction of rapid and extensive beta-chemokine synthesis in macrophages by human immunodeficiency virus type 1 and gp120, independently of their coreceptor phenotype. J Virol 75 (2001) 10738-10745
18. Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., et al. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J Virol 59 (1986) 284-291
19. Gendelman H.E., Orenstein J.M., Martin M.A., Ferrua C., Mitra R., Phipps T., et al. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 167 (1988) 1428-1441
20. Arnold R., Maueler W., Bassili G., Lutz M., Burke L., Epplen T.J., et al. The insulator protein CTCF represses transcription on binding to the (gt)(22)(ga)(15) microsatellite in intron 2 of the HLA-DRB1(*)0401 gene. Gene 253 (2000) 209-214
21. Awad T.A., Bigler J., Ulmer J.E., Hu Y.J., Moore J.M., Lutz M., et al. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J Biol Chem 274 (1999) 27092-27098
22. Burcin M., Arnold R., Lutz M., Kaiser B., Runge D., Lottspeich F., et al. Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol Cell Biol 17 (1997) 1281-1288
23. Li G., Aaron S., Kazmierczak K., Lesner A., Li Y., Ivanova A., et al. Inhibition of HIV-1 or bacterial activation of macrophages by products of HIV-1-resistant human cells. Immunol Cell Biol 85 (2007) 603-609
24. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
25. Chernukhin I.V., Shamsuddin S., Robinson A.F., Carne A.F., Paul A., El-Kady A.I., et al. Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF. J Biol Chem 275 (2000) 29915-29921
26. Lutz M., Burke L.J., Barreto G., Goeman F., Greb H., Arnold R., et al. Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res 28 (2000) 1707-1713
27. Amelio A.L., McAnany P.K., and Bloom D.C. A chromatin insulator-like element in the herpes simplex virus type 1 latency-associated transcript region binds CCCTC-binding factor and displays enhancer-blocking and silencing activities. J Virol 80 (2006) 2358-2368
28. Ansari S.A., Safak M., Gallia G.L., Sawaya B.E., Amini S., and Khalili K. Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity. J Gen Virol 80 Pt 10 (1999) 2629-2638
29. Klenova E., Scott A.C., Roberts J., Shamsuddin S., Lovejoy E.A., Bergmann S., et al. YB-1 and CTCF differentially regulate the 5-HTT polymorphic intron 2 enhancer which predisposes to a variety of neurological disorders. J Neurosci 24 (2004) 5966-5973
30. Sawaya B.E., Khalili K., and Amini S. Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat. J Gen Virol 79 Pt 2 (1998) 239-246
31. Chau C.M., Zhang X.Y., McMahon S.B., and Lieberman P.M. Regulation of Epstein-Barr virus latency type by the chromatin boundary factor CTCF. J Virol 80 (2006) 5723-5732
32. Schreck R., Zorbas H., Winnacker E.L., and Baeuerle P.A. The NF-kappa B transcription factor induces DNA bending which is modulated by its 65-kDa subunit. Nucleic Acids Res 18 (1990) 6497-6502