A novel transgenic mouse model produced from lentiviral germline integration for the study of β-thalassemia gene therapy

Haematologica

Volumn 93, Issue 3, 2008, Pages 356-362

  Li, Wei ^a   Xie, Shuyang ^a   Guo, Xinbing ^a   Gong, Xiuli ^a   Wang, Shu ^a   Lin, Dan ^a   Zhang, Jingzhi ^a   Ren, Zhaorui ^a   Huang, Shuzhen ^a   Zeng, Fanyi ^a   Zeng, Yi Tao ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

thalassemia; Gene therapy; Lentiviral vector; Subzonal injection; Transgenic mouse

Indexed keywords

BETA GLOBIN; GENOMIC DNA; LENTIVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA THALASSEMIA; CONTROLLED STUDY; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE THERAPY; GERM LINE; MOUSE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENE; TREATMENT OUTCOME; WESTERN BLOTTING;

ANIMALS; BETA-THALASSEMIA; BONE MARROW; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; GENETIC VECTORS; GERM-LINE MUTATION; GLOBINS; HUMANS; LENTIVIRUS; LIVER; MALE; MICE; MICE, MUTANT STRAINS; MICE, TRANSGENIC; MICROINJECTIONS; MUTAGENESIS, INSERTIONAL; RECOMBINANT FUSION PROTEINS; SPLEEN; VIRUS INTEGRATION;

EID: 40849114579     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.12010     Document Type: Article

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