Human DDA3 is an oncoprotein down-regulated by p53 and DNA damage

Biochemical and Biophysical Research Communications

Volumn 369, Issue 2, 2008, Pages 567-572

  Hsieh, Wang Ju ^a   Hsieh, Shu Chen ^a   Chen, Chia Chen ^a   Wang, Fung Fang ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

DDA3; p53 target; Species specific gene regulation

Indexed keywords

DNA; LUCIFERASE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PROTEIN DDA3; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA DAMAGE; GENE; GENE CONTROL; GENE REPRESSION; GENETIC TRANSCRIPTION; HDDA3 GENE; HUMAN; HUMAN CELL; INTRON; LIVER CELL CARCINOMA; MICROTUBULE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SERUM;

CARCINOMA, HEPATOCELLULAR; DNA DAMAGE; DOWN-REGULATION; HELA CELLS; HUMANS; PHOSPHOPROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 40849114514     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.02.047     Document Type: Article

References (23)

1. Kaelin Jr. W.G. Another p53 Doppelganger?. Science 281 (1998) 57-58
2. Adimoolam S., and Ford J.M. p53 and regulation of DNA damage recognition during nucleotide excision repair. DNA Repair 2 (2003) 947-954
3. Hofseth L.J., Hussain S.P., and Harris C.C. p53: 25 years after its discovery. Trends Pharmacol. Sci. 25 (2004) 177-181
4. Vogelstein B., Lane D., and Levine A.J. Surfing the p53 network. Nature 408 (2000) 307-310
5. Levine A.J., Finlay C.A., and Hinds P.W. P53 is a tumor suppressor gene. Cell 116 (2004) S67-S69
6. El-Deiry W.S., Kern S.E., Pietenpol J.A., Kinzler K.W., and Vogelstein B. Definition of a consensus binding site for p53. Nat. Genet. 1 (1992) 45-49
7. Farmer G., Bargonetti J., Zhu H., Friedman P., Prywes R., and Prives C. Wild-type p53 activates transcription in vitro. Nature 358 (1992) 83-86
8. Laptenko O., and Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ. 13 (2006) 951-961
9. Hsieh P.C., Chang J.C., Sun W.T., Hsieh S.C., Wang M.C., and Wang F.F. p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates beta-catenin pathway. Oncogene 26 (2007) 4928-4940
10. Hsieh S.C., Lo P.K., and Wang F.F. Mouse DDA3 gene is a direct transcriptional target of p53 and p73. Oncogene 21 (2002) 3050-3057
11. Lo P.K., Chen J.Y., Lo W.C., Chen B.F., Hsin J.P., Tang P.P., and Wang F.F. Identification of a novel mouse p53 target gene DDA3. Oncogene 18 (1999) 7765-7774
12. Lo P.K., and Wang F.F. Cloning and characterization of human and mouse DDA3 genes. Biochim. Biophys. Acta 1579 (2002) 214-218
13. Sasaki Y., Ishida S., Morimoto I., Yamashita T., Kojima T., Kihara C., Tanaka T., Imai K., Nakamura Y., and Tokino T. The p53 family member genes are involved in the Notch signal pathway. J. Biol. Chem. 277 (2002) 719-724
14. Strahl-Bolsinger S., Hecht A., Luo K., and Grunstein M. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev. 11 (1997) 83-93
15. Lin Y.C., and Wang F.F. Mechanisms underlying the pro-survival pathway of p53 in suppressing mitotic death induced by adriamycin. Cell. Signal. 20 (2008) 258-267
16. Tsou A.P., Yang C.W., Huang C.Y., Yu R.C., Lee Y.C., Chang C.W., Chen B.R., Chung Y.F., Fann M.J., Chi C.W., Chiu J.H., and Chou C.K. Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene 22 (2003) 298-307
17. Menendez D., Inga A., Jordan J.J., and Resnick M.A. Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson. Oncogene 26 (2007) 2191-2201
18. Johnson R.A., Ince T.A., and Scotto K.W. Transcriptional repression by p53 through direct binding to a novel DNA element. J. Biol. Chem. 276 (2001) 27716-27720
19. Budhram-Mahadeo V., Morris P.J., Smith M.D., Midgley C.A., Boxer L.M., and Latchman D.S. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J. Biol. Chem. 274 (1999) 15237-15244
20. Lee K.C., Crowe A.J., and Barton M.C. p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol. Cell. Biol. 19 (1999) 1279-1288
21. Ori A., Zauberman A., Doitsh G., Paran N., Oren M., and Shaul Y. p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53. EMBO J. 17 (1998) 544-553
22. Miller S.J., Rangwala F., Williams J., Ackerman P., Kong S., Jegga A.G., Kaiser S., Aronow B.J., Frahm S., Kluwe L., Mautner V., Upadhyaya M., Muir D., Wallace M., Hagen J., Quelle D.E., Watson M.A., Perry A., Gutmann D.H., and Ratner N. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Res. 66 (2006) 2584-2591
23. Tan T., and Chu G. p53 binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. Mol. Cell. Biol. 22 (2002) 3247-3254