Relation among mannose-binding lectin 2 genotype, β-cell autoantibodies, and risk for type 1 diabetes in Finnish children

Human Immunology

Volumn 69, Issue 2, 2008, Pages 108-111

  Aittoniemi, J ^a   Turpeinen, H ^b   Tiittanen, M ^c   Knip, M ^d,e   Simell, O ^b   Ilonen, J ^b   Vaarala, O ^c,f  

^a PIRKANMAA HOSPITAL DISTRICT   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

^f Diabetes Research Centre   (Sweden)

Author keywords

cell autoantibodies; Mannose binding lectin; Type 1 diabetes

Indexed keywords

MANNOSE BINDING LECTIN 2;

ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; DNA POLYMORPHISM; GENE FREQUENCY; GENOTYPE; HEALTH HAZARD; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ADOLESCENT; AUTOANTIBODIES; AUTOANTIGENS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE SUSCEPTIBILITY; FEMALE; FINLAND; GENOTYPE; HLA-DQ ANTIGENS; HUMANS; INFANT; INSULIN-SECRETING CELLS; MALE; MANNOSE-BINDING LECTIN; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 40849104738     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.01.007     Document Type: Article

References (21)

1. Turner M.W., and Hamvas R.M. Mannose-binding lectin structure: function, genetics and disease associations. Rev Immunogenet 2 (2000) 305
2. Turner M.W. The role of mannose-binding lectin in health and disease. Mol Immunol 40 (2003) 423
3. Garred P., Larsen F., Seyfarth J., Fujita R., and Madsen H.O. Mannose-binding lectin and its genetic variants. Genes Immun 7 (2006) 85
4. Tsutsumi A., Ikegami H., Takahashi R., Murata H., Goto D., Matsumoto I., et al. Mannose binding lectin gene polymorphism in patients with type I diabetes. Hum Immunol 64 (2003) 621
5. Araujo J., Brandão L.A., Guimarães R.L., Santos S., Falcão E.A., Milanese M., et al. Mannose binding lectin gene polymorphisms are associated with type 1 diabetes in Brazilian children and adolescents. Hum Immunol 68 (2007) 739
6. Hansen T.K., Tarnow L., Thiel S., Steffensen R., Stehouwer C.D., Schalkwijk C.G., et al. Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes 53 (2004) 1570
7. Saraheimo M., Forsblom C., Hansen T.K., Teppo A.M., Fagerudd J., Pettersson-Fernholm K., et al. Increased levels of mannan-binding lectin in type 1 diabetic patients with incipient and overt nephropathy. Diabetologia 48 (2005) 198
8. Bouwman L.H., Eerligh P., Terpstra O.T., Daha M.R., de Knijff P., Ballieux B.E., et al. Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles. Diabetes 54 (2005) 3002
9. Hansen T.K. Mannose-binding lectin (MBL) and vascular complications in diabetes. Horm Metab Res 37 Suppl 1 (2005) 95
10. Hovind P., Hansen T.K., Tarnow L., Thiel S., Steffensen R., Flyvbjerg A., et al. Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study. Diabetes 54 (2005) 1523
11. Østergaard J., Thiel S., Gadjeva M., Hansen T.K., Rasch R., and Flyvbjerg A. Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia 50 (2007) 1541
12. Atkinson M.A., and Eisenbarth G.S. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358 (2001) 221
13. Kupila A., Muona P., Simell T., Arvilommi P., Savolainen H., Hämäläinen A.M., et al. Feasibility of genetic and immunological prediction of type 1 diabetes in a population based cohort. Diabetologia 44 (2001) 290
14. Kukko M., Virtanen S.M., Toivonen A., Simell S., Korhonen S., Ilonen J., et al. Geographic variation in risk HLA-DQB1 genotypes for type 1 diabetes and signs of beta-cell autoimmunity within a high incidence country. Diabetes Care 27 (2004) 676
15. Madsen H.O., Garred P., Kurtzhals J.A.L., Lamm L.U., Ryder L.P., Thiel S., et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40 (1994) 37
16. Seiskari T., Kondrashova A., Viskari H., Kaila M., Haapala A.M., Aittoniemi J., et al., EPIVIR study group. Allergic sensitization and microbial load-a comparison between Finland and Russian Karelia. Clin Exp Immunol 148 (2007) 47
17. Aittoniemi J., Soranummi H., Rovio A.T., Hurme M., Pessi T., Nieminen M., et al. Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults. Clin Exp Immunol 142 (2005) 120
18. Field L.L. Genetic linkage and association studies on Type I diabetes: challenges and rewards. Diabetologia 45 (2002) 21
19. Kulmala P., Savola K., Reijonen H., Veijola R., Vähäsalo P., Karjalainen J., et al., Childhood Diabetes in Finland Study Group. Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Diabetes 49 (2000) 48
20. Achenbach P., Warncke K., Reiter J., Naserke H.E., Williams A.J., Bingley P.J., et al. Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53 (2004) 384
21. Ogden C.A., deCathelineau A., Hoffmann P.R., Bratton D., Ghebrehiwet B., Fadok V.A., et al. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J Exp Med 194 (2001) 781