Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia

Journal of Critical Care

Volumn 23, Issue 1, 2008, Pages 41-49

  Muscedere, John G ^a,b   McColl, Chris ^a   Shorr, Andrew ^c   Jiang, Xuran ^b   Marshall, John ^d   Heyland, Daren K ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

^c WASHINGTON HOSPITAL CENTER   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Clinical suspension of VAP; Late VAP; Ventilator associated pneumonia

Indexed keywords

ARTICLE; ARTIFICIAL VENTILATION; BACTEREMIA; COMPARATIVE STUDY; CORRELATION ANALYSIS; HUMAN; MICROBIOLOGY; OUTCOME ASSESSMENT; PATIENT CARE; PROBABILITY; RETROSPECTIVE STUDY; TREATMENT OUTCOME; VENTILATOR ASSOCIATED PNEUMONIA;

ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; APACHE; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; LENGTH OF STAY; MALE; MIDDLE AGED; PNEUMONIA, VENTILATOR-ASSOCIATED; RETROSPECTIVE STUDIES; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 40849095963     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2007.12.007     Document Type: Article

References (35)

1. Cook D.J., Walter S.D., Cook R.J., et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 129 (1998) 433-440
2. Vincent J.L., Bihari D.J., Suter P.M., et al. The prevalence of nosocomial infection in intensive care units in Europe. Results of the European Prevalence of Infection in Intensive Care (EPIC) Study. EPIC International Advisory Committee. JAMA 274 (1995) 639-644
3. Safdar N., Dezfulian C., Collard H.R., et al. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33 (2005) 2184-2193
4. Heyland D.K., Cook D.J., Griffith L., et al. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. Am J Respir Crit Care Med 159 (1999) 1249-1256
5. Rello J., Ollendorf D.A., Oster G., et al., for the VAP Outcomes Scientific Advisory Group. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest 122 (2002) 2115-2121
6. Girou E., Stephan F., Novara A., et al. Risk factors and outcome of nosocomial infections: results of a matched case-control study of ICU patients. Am J Respir Crit Care Med 157 (1998) 1151-1158
7. Bueno-Cavanillas A., Delgado-Rodriguez M., Lopez-Luque A., et al. Influence of nosocomial infection on mortality rate in an intensive care unit. Crit Care Med 22 (1994) 55-60
8. American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171 (2005) 388-416
9. Michaud S., Suzuki S., and Harbarth S. Effect of design-related bias in studies of diagnostic tests for ventilator-associated pneumonia. Am J Respir Crit Care Med 166 (2002) 1320-1325
10. Waterer G.W., and Wunderink R.G. Controversies in the diagnosis of ventilator-acquired pneumonia. Med Clin North Am 85 (2001) 1565-1581
11. Torres A., and El-Ebiary M. Bronchoscopic BAL in the diagnosis of ventilator-associated pneumonia. Chest 117 4 Suppl 2 (2000) 198S-202S
12. Campbell Jr. G.D. Blinded invasive diagnostic procedures in ventilator-associated pneumonia. Chest 117 4 Suppl 2 (2000) 207S-211S
13. Baughman R.P. Protected-specimen brush technique in the diagnosis of ventilator-associated pneumonia. Chest 117 4 Suppl 2 (2000) 203-206
14. Fagon J.Y., Chastre J., Wolff M., et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia: a randomized trial. Ann Intern Med 132 (2000) 621-630
15. Luna C.M., Vujacich P., Niederman, et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 111 (1997) 676-685
16. Heyland, DK, Dodek P, Muscedere J, et al. A randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med doi:10.1097/01.ccm.0B013E31816203D6.
17. Sole Violan J., Fernandez J.A., Benitez A.B., et al. Impact of quantitative invasive diagnostic techniques in the management and outcome of mechanically ventilated patients with suspected pneumonia. Crit Care Med 28 (2000) 2737-2741
18. Ruiz M., Torres A., Ewig S., et al. Noninvasive versus invasive microbial investigation in ventilator-associated pneumonia: evaluation of outcome. Am J Respir Crit Care Med 162 (2000) 119-125
19. Calandra T., and Cohen J. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med 33 (2005) 1538-1548
20. Heyland D., Dodek P., Day A., et al., for the Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques for suspected ventilator-associated pneumonia. N Engl J Med 355 (2006) 2619-2630
21. Marshall J.C., Cook D.J., Christou N.V., et al. Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23 (1995) 1638-1652
22. Pugin J., Auckenthaler R., Mili N., et al. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic "blind" bronchoalveolar lavage fluid. Am Rev Respir Dis 143 (1991) 1121-1129
23. Singh N., Rogers P., Atwood C.W., et al. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med 162 (2000) 505-511
24. Hosmer D.J., and Lemeshow S. Applied logistic regression (1989), John Wiley and Sons, New York (NY)
25. Nseir S., Di Pompeo C., Soubrier S., et al. Impact of ventilator-associated pneumonia on outcome in patients with COPD. Chest 128 (2005) 1650-1656
26. Papazian L., Bregeon F., Thirion X., et al. Effect of ventilator-associated pneumonia on mortality and morbidity. Am J Respir Crit Care Med 154 (1996) 91-97
27. Warren D., Shukla J., Olsen M., et al. Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med 31 (2003) 1312-1317
28. Bone R. Towards an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). Ann Intern Med 268 (2002) 3452-3455
29. Confalonieri M., Urbino R., Potena A., et al. Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study. Am J Respir Crit Care Med 171 (2005) 242-248
30. Agbhat K., Diaz E., Munoz E., et al. Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: a study comparing bacteremic vs. nonbacteremic ventilator associated pneumonia. Crit Care Med 35 (2007) 2064-2070
31. Fartoukh M., Maitre B., Honore S., et al. Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited. Am J Respir Crit Care Med 168 (2003) 173-179
32. Luyt C.E., Chastre J., and Fagon J.Y. Value of the clinical pulmonary infection score for the identification and management of ventilator-associated pneumonia. Intensive Care Med 30 (2004) 844-852
33. Schurink C.A., Van Nieuwenhoven C.A., Jacobs J.A., et al. Clinical pulmonary infection score for ventilator-associated pneumonia: accuracy and inter-observer variability. Intensive Care Med 30 (2004) 217-224
34. Croce M.A., Swanson J.M., Magnotti L.J., et al. The futility of the clinical pulmonary infection score in trauma patients. J Trauma 60 (2006) 523-527 [discussion 527-8]
35. Seligman R., Meisner M., Lisboa T., et al. Decreases in procalcitonin and C-reactive protein are strong predictors of survival in ventilator-associated pneumonia. Crit Care 6 10 (2006) R125