SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2499-2512

  Dalence Guzmán, María F ^a,b   Berglund, Magnus ^a   Skogvall, Staffan ^c   Sterner, Olov ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSIDAD MAYOR DE SAN SIMÓN   (Bolivia)

^c Respiratorius AB   (Sweden)

Author keywords

1,2,3,4 Tetrahydroisoquinoline; 2,3,4,5 Tetrahydro 1H 2 azepine; 2,3,4,5 Tetrahydro 1H 3 benzazepine; A ring catechol; Asthma; B ring; Bronchodilator; Capsazepine; COPD; Isoindoline; SAR; Small human airways

Indexed keywords

1 BENZYL N [2 (4 CHLOROPHENYL)ETHYL] 6,7 DIHYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; BENZAZEPINE DERIVATIVE; BRONCHODILATING AGENT; CAPSAZEPINE; CATECHOL; LEUKOTRIENE D4; N [2 (4 CHLOROPHENYL)ETHYL] 4 HYDROXY 1,3 DIHYDRO 2H ISOINDOLE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 5 HYDROXY 1,3 DIHYDRO 2H ISOINDOLE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 5 HYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 5,6 DIHYDROXY 1,3 DIHYDRO 2H ISOINDOLE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 6 HYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 6,7 DIHYDROXY 1 METHYL 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 6,7 DIHYDROXY 3 METHYL 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 6,7 DIHYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 7 HYDROXY 1,3,4,5 TETRAHYDRO 2H 2 BENZAZEPINE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 7 HYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 7,8 DIHYDROXY 1,3,4,5 TETRAHYDRO 2H 2 BENZAZEPINE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 7,8 DIHYDROXY 1,3,4,5 TETRAHYDRO 3H 3 BENZAZEPINE 3 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 8 HYDROXY 1,3,4,5 TETRAHYDRO 2H 2 BENZAZEPINE 2 CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] 8 HYDROXY 3,4 DIHYDROISOQUINOLINE 2(1H)CARBOTHIOAMIDE; N [2 (4 CHLOROPHENYL)ETHYL] N' (3,4 DIHYDROXYBENZYL)THIOUREA; N [2 (4 CHLOROPHENYL)ETHYL] N' [2 (3,4 DIHYDROXYBENZYL)ETHYL]THIOUREA; N' [2 (4 CHLOROPHENYL)ETHYL] N (3,4 DIHYDROXYBENZYL) N METHYLTHIOUREA; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; STRUCTURE ACTIVITY RELATION;

BRONCHODILATOR AGENTS; CAPSAICIN; CATECHOLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RESPIRATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40749142752     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.055     Document Type: Article

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