U-69593, a Kappa Opioid Receptor Agonist, Decreases Cocaine-Induced Behavioral Sensitization in Female Rats

Behavioral Neuroscience

Volumn 122, Issue 1, 2008, Pages 151-160

  Puig Ramos, Anabel ^a   Santiago, Gladys S ^a   Segarra, Annabell C ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

behavioral sensitization; cocaine; estradiol; estrogen; female rats; kappa opioid receptors

Indexed keywords

COCAINE; ESTRADIOL; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EXPOSURE; FEMALE; LOCOMOTION; NEUROMODULATION; NONHUMAN; OVARIECTOMY; RAT; REGULATORY MECHANISM; SENSITIZATION;

ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BENZENEACETAMIDES; COCAINE; DOPAMINE UPTAKE INHIBITORS; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ESTRADIOL; ESTROGENS; FEMALE; MOTOR ACTIVITY; OVARIECTOMY; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 40749124342     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.122.1.151     Document Type: Article

References (66)

1. Abizaid A., Mezei G., Thanarajasingam G., and Horvath T.L. Estrogen enhances light-induced activation of dorsal raphe serotonergic neurons. European Journal of Neuroscience 21 (2005) 1536-1546
2. Adams D.H., Hanson G.R., and Keefe K.A. Cocaine and methamphetamine differentially affect opioid peptide mRNA expression in the striatum. Journal of Neurochemistry 75 (2000) 2061-2070
3. Anderson S.M., and Pierce R.C. Cocaine-induced alterations in dopamine receptor signaling: Implications for reinforcement and reinstatement. Pharmacology and Therapeutics 106 (2005) 389-403
4. Chefer V.I., Czyzyk T., Bolan E.A., Moron J., Pintar J.E., and Shippenberg T.S. Endogenous kappa-opioid receptor systems regulate mesoaccumbal dopamine dynamics and vulnerability to cocaine. Journal of Neuroscience 25 (2005) 5029-5037
5. Craft R.M. Sex differences in opioid analgesia: "From mouse to man.". Clinical Journal of Pain 19 (2003) 175-186
6. Craft R.M., Mogil J.S., and Aloisi A.M. Sex differences in pain and analgesia: The role of gonadal hormones. European Journal of Pain 8 (2004) 397-411
7. Daunais J.B., Roberts D.C., and McGinty J.F. Cocaine self-administration increases preprodynorphin, but not c-fos, mRNA in rat striatum. Neuroreport 4 (1993) 543-546
8. Dawson-Basoa M.E., and Gintzler A.R. Estrogen and progesterone activate spinal kappa-opiate receptor analgesic mechanisms. Pain 64 (1996) 608-615
9. Febo M., Ferris C.F., and Segarra A.C. Estrogen influences cocaine-induced blood oxygen level-dependent signal changes in female rats. Journal of Neuroscience 25 (2005) 1132-1136
10. Febo M., Gonzalez-Rodriguez L.A., Capo-Ramos D.E., Gonzalez-Segarra N.Y., and Segarra A.C. Estrogen-dependent alterations in D2/D3-induced G protein activation in cocaine-sensitized female rats. Journal of Neurochemistry 86 (2003) 405-412
11. Febo M., Jimenez-Rivera C.A., and Segarra A.C. Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat. Brain Research 943 (2002) 151-161
12. Febo M., and Segarra A.C. Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: Modulation by estrogen. Synapse 54 (2004) 30-36
13. Fillingim R.B., and Gear R.W. Sex differences in opioid analgesia: Clinical and experimental findings. European Journal of Pain 8 (2004) 413-425
14. Hammer Jr. R.P., Zhou L., and Cheung S. Gonadal steroid hormones and hypothalamic opioid circuitry. Hormones and Behavior 28 (1994) 431-437
15. Haney M., Castanon N., Cador M., Le M.M., and Mormede P. Cocaine sensitivity in Roman high and low avoidance rats is modulated by sex and gonadal hormone status. Brain Research 645 (1994) 179-185
16. Heidbreder C.A., Babovic-Vuksanovic D., Shoaib M., and Shippenberg T.S. Development of behavioral sensitization to cocaine: Influence of kappa opioid receptor agonists. Journal of Pharmacology and Experimental Therapeutics 275 (1995) 150-163
17. Heidbreder C.A., Goldberg S.R., and Shippenberg T.S. The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat. Brain Research 616 (1993) 335-338
18. Heidbreder C.A., and Shippenberg T.S. U-69593 prevents cocaine sensitization by normalizing basal accumbens dopamine. Neuroreport 5 (1994) 1797-1800
19. Hu M., and Becker J.B. Effects of sex and estrogen on behavioral sensitization to cocaine in rats. Journal of Neuroscience 23 (2003) 693-699
20. Hurd Y.L., and Herkenham M. Influence of a single injection of cocaine, amphetamine or GBR 12909 on mRNA expression of striatal neuropeptides. Molecular Brain Research 16 (1992) 97-104
21. Jezierski M.K., and Sohrabji F. Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain. Endocrinology 144 (2003) 5022-5029
22. Kaminski R.M., Witkin J.M., and Shippenberg T.S. Pharmacological and genetic manipulation of kappa opioid receptors: Effects on cocaine and pentylenetetrazol-induced convulsions and seizure kindling. Neuropharmacology 52 (2007) 895-903
23. Kiyatkin E.A., and Brown P.L. Naloxone depresses cocaine self-administration and delays its initiation on the following day. Neuroreport 14 (2003) 251-255
24. Koob G.F., Sanna P.P., and Bloom F.E. Neuroscience of addiction. Neuron 21 (1998) 467-476
25. Kritzer M.F. Selective colocalization of immunoreactivity for intracellular gonadal hormone receptors and tyrosine hydroxylase in the ventral tegmental area, substantia nigra, and retrorubral fields in the rat. Journal of Comparative Neurology 379 (1997) 247-260
26. Kuppers E., Ivanova T., Karolczak M., and Beyer C. Estrogen: A multifunctional messenger to nigrostriatal dopaminergic neurons. Journal of Neurocytology 29 (2000) 375-385
27. Kuzmin A.V., Semenova S., Gerrits M.A., Zvartau E.E., and van Ree J.M. Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. European Journal of Pharmacology 321 (1997) 265-271
28. Legan S.J., Coon G.A., and Karsch F.J. Role of estrogen as initiator of daily LH surges in the ovariectomized rat. Endocrinology 96 (1975) 50-56
29. National Institutes of Health. Guide for the care and use of laboratory animals. (DHEW Publication No. 86-23) (1986), U.S. Government Printing Office, Washington, DC
30. Negus S.S., and Mello N.K. Opioid antinociception in ovariectomized monkeys: Comparison with antinociception in males and effects of estradiol replacement. Journal of Pharmacology and Experimental Therapeutics 290 (1999) 1132-1140
31. Peris J., Decambre N., Coleman-Hardee M.L., and Simpkins J.W. Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release. Brain Research 566 (1991) 255-264
32. Pierce R.C., and Kalivas P.W. A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Reseach Reviews 25 (1997) 192-216
33. Pittman K.J., and Fibiger H.C. The effects of estrogen on apomorphine-induced hypothermia and stereotypy in the rat. Neuropharmacology 22 (1983) 587-592
34. Quinones-Jenab V., Jenab S., Ogawa S., Inturrisi C., and Pfaff D.W. Estrogen regulation of mu-opioid receptor mRNA in the forebrain of female rats. Molecular Brain Research 47 (1997) 134-138
35. Ratka A., and Simpkins J.W. Effects of estradiol and progesterone on the sensitivity to pain and on morphine-induced antinociception in female rats. Hormones and Behavior 25 (1991) 217-228
36. Robinson T.E. Behavioral sensitization: Characterization of enduring changes in rotational behavior produced by intermittent injections of amphetamine in male and female rats. Psychopharmacology (Berlin) 84 (1984) 466-475
37. Robinson T.E., and Berridge K.C. Addiction. Annual Review of Psychology 54 (2003) 25-53
38. Romano G.J., Mobbs C.V., Lauber A., Howells R.D., and Pfaff D.W. Differential regulation of proenkephalin gene expression by estrogen in the ventromedial hypothalamus of male and female rats: Implications for the molecular basis of a sexually differentiated behavior. Brain Research 536 (1990) 63-68
39. Schenk S., Partridge B., and Shippenberg T.S. U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking. Psychopharmacology (Berlin) 144 (1999) 339-346
40. Schenk S., Partridge B., and Shippenberg T.S. Effects of the kappa-opioid receptor agonist, U69593, on the development of sensitization and on the maintenance of cocaine self-administration. Neuropsychopharmacology 24 (2001) 441-450
41. Schmidt H.D., Anderson S.M., Famous K.R., Kumaresan V., and Pierce R.C. Anatomy and pharmacology of cocaine priming-induced reinstatement of drug seeking. European Journal of Pharmacology 526 (2005) 65-76
42. Schwarz S., and Pohl P. Steroids and opioid receptors. Journal of Steroid Biochemistry and Molecular Biology 48 (1994) 391-402
43. Segarra A.C., Acosta A.M., Gonzalez J.L., Angulo J.A., and McEwen B.S. Sex differences in estrogenic regulation of preproenkephalin mRNA levels in the medial preoptic area of prepubertal rats. Molecular Brain Research 60 (1998) 133-139
44. Segarra A.C., and Lee S.J. Neuroprotective effects of estrogen. In: Legato M.J. (Ed). Principles of gender specific medicine 1 (2004) 96-103
45. Sell S.L., Scalzitti J.M., Thomas M.L., and Cunningham K.A. Influence of ovarian hormones and estrous cycle on the behavioral response to cocaine in female rats. Journal of Pharmacology and Experimental Therapeutics 293 (2000) 879-886
46. Shippenberg T.S., Chefer V.I., Zapata A., and Heidbreder C.A. Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems. Annals of the New York Academy of Science 937 (2001) 50-73
47. Shippenberg T.S., LeFevour A., and Heidbreder C. Kappa-opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine. Journal of Pharmacology and Experimental Therapeutics 276 (1996) 545-554
48. Shippenberg T.S., and Rea W. Sensitization to the behavioral effects of cocaine: Modulation by dynorphin and kappa-opioid receptor agonists. Pharmacology Biochemistry and Behavior 57 (1997) 449-455
49. Shippenberg T.S., Le Favour A., and Thompson A.C. Sensitization to the conditioned rewarding effects of morphine and cocaine: Differential effects of the kappa-opioid receptor agonist U69593. European Journal of Pharmacology 345 (1998) 27-34
50. Sircar R., and Kim D. Female gonadal hormones differentially modulate cocaine-induced behavioral sensitization in Fischer, Lewis, and Sprague-Dawley rats. Journal of Pharmacology and Experimental Therapeutics 289 (1999) 54-65
51. Sivam S.P. Cocaine selectively increases striatonigral dynorphin levels by a dopaminergic mechanism. Journal of Pharmacology and Experimental Therapeutics 250 (1989) 818-824
52. Spampinato S., Canossa M., Campana G., Carboni L., and Bachetti T. Estrogen regulation of prodynorphin gene expression in the rat adenohypophysis: Effect of the antiestrogen tamoxifen. Endocrinology 136 (1995) 1589-1594
53. Spanagel R., Herz A., and Shippenberg T.S. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences, USA 89 (1992) 2046-2050
54. Spanagel R., and Weiss F. The dopamine hypothesis of reward: past and current status. Trends Neurosciences 22 (1999) 521-527
55. Spangler R., Unterwald E.M., and Kreek M.J. "Binge" cocaine administration induces a sustained increase of prodynorphin mRNA in rat caudate-putamen. Molecular Brain Research 19 (1993) 323-327
56. Spangler R., Zhou Y., Maggos C.E., Schlussman S.D., Ho A., and Kreek M.J. Prodynorphin, proenkephalin and kappa opioid receptor mRNA responses to acute "binge" cocaine. Molecular Brain Research 44 (1997) 139-142
57. Spealman R.D., and Bergman J. Modulation of the discriminative stimulus effects of cocaine by mu and kappa opioids. Journal of Pharmacology and Experimental Therapeutics 261 (1992) 607-615
58. Stoffel E.C., Ulibarri C.M., Folk J.E., Rice K.C., and Craft R.M. Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats. Journal of Pain 6 (2005) 261-274
59. Svingos A.L., Chavkin C., Colago E.E., and Pickel V.M. Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. Synapse 42 (2001) 185-192
60. Thompson A.C., Zapata A., Justice Jr. J.B., Vaughan R.A., Sharpe L.G., and Shippenberg T.S. Kappa-opioid receptor activation modifies dopamine uptake in the nucleus accumbens and opposes the effects of cocaine. Journal of Neuroscience 20 (2000) 9333-9340
61. Thompson T.L., and Moss R.L. Modulation of mesolimbic dopaminergic activity over the rat estrous cycle. Neuroscience Letters 229 (1997) 145-148
62. Unterwald E.M., Ho A., Rubenfeld J.M., and Kreek M.J. Time course of the development of behavioral sensitization and dopamine receptor up-regulation during binge cocaine administration. Journal of Pharmacology and Experimental Therapeutics 270 (1994) 1387-1396
63. Unterwald E.M., Horne-King J., and Kreek M.J. Chronic cocaine alters brain mu opioid receptors. Brain Research 584 (1992) 314-318
64. Vanderschuren L.J., Schoffelmeer A.N., Wardeh G., and De Vries T.J. Dissociable effects of the kappa-opioid receptor agonists bremazocine, U69593, and U50488H on locomotor activity and long-term behavioral sensitization induced by amphetamine and cocaine. Psychopharmacology 150 (2000) 35-44
65. Wagner E.J., Manzanares J., Moore K.E., and Lookingland K.J. Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent. Neuroendocrinology 59 (1994) 197-201
66. Xiao L., Jackson L.R., and Becker J.B. The effect of estradiol in the striatum is blocked by ICI 182,780 but not tamoxifen: Pharmacological and behavioral evidence. Neuroendocrinology 77 (2003) 239-245