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40749115138
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A part of this paper has been reported in a preliminary form.
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A part of this paper has been reported in a preliminary form.
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24
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40749141102
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Detailed procedures for the large scale synthesis of N-benzylpiperidine have been published separately.
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Detailed procedures for the large scale synthesis of N-benzylpiperidine have been published separately.
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40749101470
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Asymmetric hydrogenation of cyclic imines catalyzed by transition metal complex with chiral ligand is another method for the synthesis of optically active cyclic amines.
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Asymmetric hydrogenation of cyclic imines catalyzed by transition metal complex with chiral ligand is another method for the synthesis of optically active cyclic amines.
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35
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40749120435
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note
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3 as base (Y = 70% with 87% de). However, a slightly better result was obtained with use of KOAc as base.
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36
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40749137737
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note
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A small extent of racemization of the auxiliary 1-phenylethyl group can account for the reduced enantiomeric excess of the products. This racemization would be probably due to isomerization of imine and/or iminium intermediate as is shown below.
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