Sildenafil (viagra) evokes retinal arteriolar dilation: dual pathways via NOS activation and phosphodiesterase inhibition

Investigative Ophthalmology and Visual Science

Volumn 49, Issue 2, 2008, Pages 720-725

  Yuan, Zhaoxu ^a   Hein, Travis W ^a   Rosa, Robert H ^a   Kuo, Lih ^a,b  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^b TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; GLIBENCLAMIDE; GUANYLATE CYCLASE; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; POTASSIUM CHANNEL; SILDENAFIL; TETRYLAMMONIUM; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CYCLIC GMP PHOSPHODIESTERASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENZYME INHIBITOR; NITRIC OXIDE; PHOSPHODIESTERASE INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ARTERIOLE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; MALE; NONHUMAN; PENILE BLOOD FLOW; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASODILATATION; VASOMOTOR REFLEX; ADRENERGIC SYSTEM; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; RETINA ARTERY; SWINE;

3',5'-CYCLIC-GMP PHOSPHODIESTERASES; ANIMALS; ARTERIOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GUANYLATE CYCLASE; KATP CHANNELS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RETINAL ARTERY; SIGNAL TRANSDUCTION; SULFONES; SWINE; VASODILATION; VASODILATOR AGENTS; VASOMOTOR SYSTEM;

EID: 40649129285     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.07-1208     Document Type: Article

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