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Volumn 31, Issue 2, 2008, Pages 232-235

Fenfluramine: Riddle or Rosetta stone?

Author keywords

[No Author keywords available]

Indexed keywords

AMINOREX; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; FENFLURAMINE; POTASSIUM CHANNEL; SEROTONIN; ANOREXIGENIC AGENT; SEROTONIN UPTAKE INHIBITOR;

EID: 40649123583     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00160407     Document Type: Editorial
Times cited : (7)

References (39)
  • 1
    • 0018691139 scopus 로고
    • Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: Post or propter
    • Gurtner H. Pulmonary hypertension, "plexogenic pulmonary arteriopathy" and the appetite depressant drug aminorex: post or propter. Bull Eur Physiopath Res 1979; 15: 897-923.
    • (1979) Bull Eur Physiopath Res , vol.15 , pp. 897-923
    • Gurtner, H.1
  • 2
    • 0015665898 scopus 로고
    • Epidemiologische untersuchungen zum zusammenhang zwischen appetitzueglere innahme und primaer vasculaer pulmonaler hypertonie. [Epidemiologic studies on the relation between use of appetite depressants and primary vascular pulmonary hypertension.]
    • Greiser E. Epidemiologische untersuchungen zum zusammenhang zwischen appetitzueglere innahme und primaer vasculaer pulmonaler hypertonie. [Epidemiologic studies on the relation between use of appetite depressants and primary vascular pulmonary hypertension.] Internist 1973; 14: 437-442.
    • (1973) Internist , vol.14 , pp. 437-442
    • Greiser, E.1
  • 3
    • 9444287592 scopus 로고    scopus 로고
    • Appetite-suppressant drugs and the risk of primary pulmonary hypertension
    • Abenhaim L, Moride Y, Brenot F, et al. Appetite-suppressant drugs and the risk of primary pulmonary hypertension. N Engl J Med 1996; 335: 609-616.
    • (1996) N Engl J Med , vol.335 , pp. 609-616
    • Abenhaim, L.1    Moride, Y.2    Brenot, F.3
  • 4
    • 40649100110 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension associated with fenfluramine exposure: Report of 109 cases
    • Souza R, Humbert M, Sztrymf B, et al. Pulmonary arterial hypertension associated with fenfluramine exposure: report of 109 cases. Eur Respir J 2008; 31: 343-348.
    • (2008) Eur Respir J , vol.31 , pp. 343-348
    • Souza, R.1    Humbert, M.2    Sztrymf, B.3
  • 5
    • 0033623296 scopus 로고    scopus 로고
    • Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-b family
    • Thompson J, Machado R, Pauciulo M, et al. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-b family. J Med Genet 2003; 37: 741-745.
    • (2003) J Med Genet , vol.37 , pp. 741-745
    • Thompson, J.1    Machado, R.2    Pauciulo, M.3
  • 6
    • 0031551969 scopus 로고    scopus 로고
    • Cardiac valuvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997
    • From the Centers for Disease Control and Prevention
    • From the Centers for Disease Control and Prevention. Cardiac valuvulopathy associated with exposure to fenfluramine or dexfenfluramine: US Department of Health and Human Services interim public health recommendations, November 1997. JAMA 1997; 278: 1729-1731.
    • (1997) JAMA , vol.278 , pp. 1729-1731
  • 7
    • 20144389923 scopus 로고    scopus 로고
    • Long-term serotonin administration induces heart valve disease in rats
    • Gustafsson B, Tømmerås K, Nordrum I, et al. Long-term serotonin administration induces heart valve disease in rats. Circulation 2005; 111: 1517-1522.
    • (2005) Circulation , vol.111 , pp. 1517-1522
    • Gustafsson, B.1    Tømmerås, K.2    Nordrum, I.3
  • 8
    • 0033989494 scopus 로고    scopus 로고
    • Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine
    • Fitzgerald L, Burn T, Brown B, et al. Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine. Mol Pharmacol 2000; 57: 75-81.
    • (2000) Mol Pharmacol , vol.57 , pp. 75-81
    • Fitzgerald, L.1    Burn, T.2    Brown, B.3
  • 9
    • 33644865941 scopus 로고    scopus 로고
    • Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice
    • Mekontso-Dessap A, Brouri F, Pascal O, et al. Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation 2006; 113: 81-89.
    • (2006) Circulation , vol.113 , pp. 81-89
    • Mekontso-Dessap, A.1    Brouri, F.2    Pascal, O.3
  • 10
    • 0028018831 scopus 로고
    • Effects of chronic treatment with dexfenfluramine on serotonin in rat blood, brain and lung tissue
    • Celada P, Martín F, Artigas F. Effects of chronic treatment with dexfenfluramine on serotonin in rat blood, brain and lung tissue. Life Sci 1994; 55: 1237-1243.
    • (1994) Life Sci , vol.55 , pp. 1237-1243
    • Celada, P.1    Martín, F.2    Artigas, F.3
  • 12
    • 33745947405 scopus 로고    scopus 로고
    • Amphetamine analogs increase plasma serotonin: Implications for cardiac and pulmonary disease
    • Zolkowska D, Rothman R, Baumann M. Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther 2006; 318: 604-610.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 604-610
    • Zolkowska, D.1    Rothman, R.2    Baumann, M.3
  • 13
    • 20344365090 scopus 로고    scopus 로고
    • Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats
    • Guignabert C, Raffestin B, Benferhat R, et al. Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Circulation 2005; 111: 2812-2819.
    • (2005) Circulation , vol.111 , pp. 2812-2819
    • Guignabert, C.1    Raffestin, B.2    Benferhat, R.3
  • 14
    • 33745915236 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension
    • Kawut S, Horn E, Berekashvili K, et al. Selective serotonin reuptake inhibitor use and outcomes in pulmonary arterial hypertension. Pulm Pharmacol Ther 2006; 19: 370-374.
    • (2006) Pulm Pharmacol Ther , vol.19 , pp. 370-374
    • Kawut, S.1    Horn, E.2    Berekashvili, K.3
  • 15
    • 1542440233 scopus 로고    scopus 로고
    • The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux
    • Johnson G, Leis L, Dunlop P, Weir E. The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost 2003; 1: 2663-2668.
    • (2003) J Thromb Haemost , vol.1 , pp. 2663-2668
    • Johnson, G.1    Leis, L.2    Dunlop, P.3    Weir, E.4
  • 16
    • 0029033224 scopus 로고
    • Increased plasma serotonin in primary pulmonary hypertension
    • Herve P, Launay J, Scrobohaci M, et al. Increased plasma serotonin in primary pulmonary hypertension. Am J Med 1995; 99: 249-254.
    • (1995) Am J Med , vol.99 , pp. 249-254
    • Herve, P.1    Launay, J.2    Scrobohaci, M.3
  • 17
    • 33847688879 scopus 로고    scopus 로고
    • Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension
    • Morecroft I, Dempsie Y, Bader M, et al. Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Hypertension 2007; 49: 232-236.
    • (2007) Hypertension , vol.49 , pp. 232-236
    • Morecroft, I.1    Dempsie, Y.2    Bader, M.3
  • 18
    • 35348842184 scopus 로고    scopus 로고
    • Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: Effects on hypoxic pulmonary hypertension in mice
    • Izikki M, Hanoun N, Marcos E, et al. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. Am J Physiol 2007; 293: L1045-L1052.
    • (2007) Am J Physiol , vol.293
    • Izikki, M.1    Hanoun, N.2    Marcos, E.3
  • 19
    • 0032971293 scopus 로고    scopus 로고
    • Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin
    • Eddahibi S, Fabre V, Boni C, et al. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin. Circ Res 1999; 84: 329-336.
    • (1999) Circ Res , vol.84 , pp. 329-336
    • Eddahibi, S.1    Fabre, V.2    Boni, C.3
  • 20
    • 0034096980 scopus 로고    scopus 로고
    • Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene
    • Eddahibi S, Hanoun N, Lanfumey L, et al. Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene. J Clin Invest 2000; 105: 1555-1562.
    • (2000) J Clin Invest , vol.105 , pp. 1555-1562
    • Eddahibi, S.1    Hanoun, N.2    Lanfumey, L.3
  • 21
    • 2442519344 scopus 로고    scopus 로고
    • Over-expression of the 5-hydroxytryptamine transporter gene: Effect on pulmonary haemodynamics and hypoxia-induced pulmonary hypertension
    • MacLean M, Deuchar G, Hicks M, et al. Over-expression of the 5-hydroxytryptamine transporter gene: effect on pulmonary haemodynamics and hypoxia-induced pulmonary hypertension. Circulation 2004; 109: 2150-2155.
    • (2004) Circulation , vol.109 , pp. 2150-2155
    • MacLean, M.1    Deuchar, G.2    Hicks, M.3
  • 22
    • 0028158826 scopus 로고
    • Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture
    • Lee S, Weng W, Lanzillo J, Fanburg B. Serotonin produces both hyperplasia and hypertrophy of bovine pulmonary artery smooth muscle cells in culture. Am J Physiol 1994; 266: L46-L52.
    • (1994) Am J Physiol , vol.266
    • Lee, S.1    Weng, W.2    Lanzillo, J.3    Fanburg, B.4
  • 23
    • 0033600538 scopus 로고    scopus 로고
    • Aminorex, fenfluramine and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension
    • Rothman R, Ayestas M, Dersch C, Baumann M. Aminorex, fenfluramine and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation 1999; 100: 869-875.
    • (1999) Circulation , vol.100 , pp. 869-875
    • Rothman, R.1    Ayestas, M.2    Dersch, C.3    Baumann, M.4
  • 24
    • 0035347399 scopus 로고    scopus 로고
    • Dexfenfluramine as a mitogen signals through the formation of superoxide anion
    • Lee S, Wang W, Fanburg B. Dexfenfluramine as a mitogen signals through the formation of superoxide anion. FASEB J 2001; 15: 1324-1325.
    • (2001) FASEB J , vol.15 , pp. 1324-1325
    • Lee, S.1    Wang, W.2    Fanburg, B.3
  • 25
    • 0034776773 scopus 로고    scopus 로고
    • Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension
    • Eddahibi S, Humbert M, Fadel E, et al. Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension. J Clin Invest 2001; 108: 1141-1150.
    • (2001) J Clin Invest , vol.108 , pp. 1141-1150
    • Eddahibi, S.1    Humbert, M.2    Fadel, E.3
  • 26
    • 33646201514 scopus 로고    scopus 로고
    • Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: Critical role for serotonin-induced smooth muscle hyperplasia
    • Eddahibi S, Guignaber C, Barlier-Mur A, et al. Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia. Circulation 2006; 113: 1857-1864.
    • (2006) Circulation , vol.113 , pp. 1857-1864
    • Eddahibi, S.1    Guignaber, C.2    Barlier-Mur, A.3
  • 27
    • 30144440754 scopus 로고    scopus 로고
    • Serotonin transporter and receptors in various forms of human pulmonary hypertension
    • Marcos E, Fadel E, Sanchez O, et al. Serotonin transporter and receptors in various forms of human pulmonary hypertension. Chest 2005; 128: Suppl. 6, 552S-553S.
    • (2005) Chest , vol.128 , Issue.SUPPL. 6
    • Marcos, E.1    Fadel, E.2    Sanchez, O.3
  • 28
    • 0036799278 scopus 로고    scopus 로고
    • Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension
    • Launay J, Hervé P, Peoc'h K, et al. Function of the serotonin 5-hydroxytryptamine 2B receptor in pulmonary hypertension. Nat Med 2002; 8: 1129-1135.
    • (2002) Nat Med , vol.8 , pp. 1129-1135
    • Launay, J.1    Hervé, P.2    Peoc'h, K.3
  • 29
    • 4644248958 scopus 로고    scopus 로고
    • Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin
    • Liu Y, Suzuki Y, Day R, Fanburg B. Rho kinase-induced nuclear translocation of ERK1/ERK2 in smooth muscle cell mitogenesis caused by serotonin. Circ Res 2004; 95: 579-586.
    • (2004) Circ Res , vol.95 , pp. 579-586
    • Liu, Y.1    Suzuki, Y.2    Day, R.3    Fanburg, B.4
  • 30
    • 0029825291 scopus 로고    scopus 로고
    • Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction
    • Weir E, Reeve H, Huang J, et al. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation 1996; 94: 2216-2220.
    • (1996) Circulation , vol.94 , pp. 2216-2220
    • Weir, E.1    Reeve, H.2    Huang, J.3
  • 31
    • 1242306799 scopus 로고    scopus 로고
    • Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine
    • Hong Z, Olschewski A, Reeve H, Nelson D, Hong F, Weir E. Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol 2003; 286: L531-L538.
    • (2003) Am J Physiol , vol.286
    • Hong, Z.1    Olschewski, A.2    Reeve, H.3    Nelson, D.4    Hong, F.5    Weir, E.6
  • 32
    • 0035008770 scopus 로고    scopus 로고
    • Alterations in a redox oxygen sensing mechanism in chronic hypoxia
    • Reeve H, Michelakis E, Nelson D, Weir E, Archer S. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 2001; 90: 2249-2256.
    • (2001) J Appl Physiol , vol.90 , pp. 2249-2256
    • Reeve, H.1    Michelakis, E.2    Nelson, D.3    Weir, E.4    Archer, S.5
  • 33
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial -HIF1a - Kv channel pathway disrupts oxygen-sensing and triggers pulmonary arterial hypertension (PAH) in fawn-hooded rats: Similarities to human PAH
    • Bonnet S, Michelakis E, Porter C, et al. An abnormal mitochondrial -HIF1a - Kv channel pathway disrupts oxygen-sensing and triggers pulmonary arterial hypertension (PAH) in fawn-hooded rats: similarities to human PAH. Circulation 2006; 113: 2630-2641.
    • (2006) Circulation , vol.113 , pp. 2630-2641
    • Bonnet, S.1    Michelakis, E.2    Porter, C.3
  • 34
    • 0032491187 scopus 로고    scopus 로고
    • + channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension
    • + channels in pulmonary artery smooth muscle cells of patients with primary pulmonary hypertension. Circulation 1998; 98: 1400-1406.
    • (1998) Circulation , vol.98 , pp. 1400-1406
    • Yuan, J.1    Aldinger, B.2    Juhaszova, M.3
  • 36
    • 6344285402 scopus 로고    scopus 로고
    • Increased release of serotonin from rat ileum due to dexfenfluramine
    • Rezaie-Majd S, Murar J, Nelson D, et al. Increased release of serotonin from rat ileum due to dexfenfluramine. Am J Physiol 2004; 287: R1209-R1213.
    • (2004) Am J Physiol , vol.287
    • Rezaie-Majd, S.1    Murar, J.2    Nelson, D.3
  • 37
    • 33744970745 scopus 로고    scopus 로고
    • Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension
    • Guignabert C, Izikki M, Tu L, et al. Transgenic mice overexpressing the 5-hydroxytryptamine transporter gene in smooth muscle develop pulmonary hypertension. Circ Res 2006; 98: 1323-1330.
    • (2006) Circ Res , vol.98 , pp. 1323-1330
    • Guignabert, C.1    Izikki, M.2    Tu, L.3
  • 38
    • 33646145730 scopus 로고    scopus 로고
    • Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: Role of 5-HT2A receptors, caveolin-1 and Kv1.5 channel internalization
    • Cogolludo A, Moreno L, Lodi F, et al. Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1 and Kv1.5 channel internalization. Circ Res 2006; 98: 931-938.
    • (2006) Circ Res , vol.98 , pp. 931-938
    • Cogolludo, A.1    Moreno, L.2    Lodi, F.3
  • 39
    • 33751087216 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells
    • Fantozzi I, Platoshyn O, Wong A, et al. Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells. Am J Physiol 2006; 291: L993-L1004.
    • (2006) Am J Physiol , vol.291
    • Fantozzi, I.1    Platoshyn, O.2    Wong, A.3


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