Research ethics and lessons from Hwanggate: What can we learn from the Korean cloning fraud?

Journal of Medical Ethics

Volumn 34, Issue 3, 2008, Pages 214-221

  Saunders, R ^a   Savulescu, Julian ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CATTLE; CLONING; DOG; EMBRYONIC STEM CELL; ETHICS; FEMALE; HUMAN; INFORMED CONSENT; KOREA; OOCYTE DONATION; RESEARCH ETHICS; REVIEW; SCIENTIFIC MISCONDUCT; SWINE; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CATTLE; CLONING, ORGANISM; DOGS; EMBRYONIC STEM CELLS; ETHICS, RESEARCH; FEMALE; HUMANS; INFORMED CONSENT; KOREA; OOCYTE DONATION; SCIENTIFIC MISCONDUCT; SWINE;

EID: 40649120775     PISSN: 03066800     EISSN: None     Source Type: Journal    
DOI: 10.1136/jme.2007.023721     Document Type: Review

References (63)

1. Dreitus C. A conversation with/Woo Suk Hwang and Shin Yong Moon: 2 Friends, 242 Eggs and a Breakthrough. The New York Times 17 February 2004.
2. Anon. Editorial: Hwang's 'guardian angel' owes us an explanation. Digital Chosun Ilbo 18 January 2006.http://geneticsandsociety.org/ article.php?id = 1834 (accessed 17 Dec 2007).
3. Hwang W-S, Ryu YJ, Park JH, et al. Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst. Science 2004;303:1669-74.
4. Cyranoski D. Korea's stem-cell stars dogged by suspicion of ethical breach. Nature 2004;429:3.
5. KBA. Korean Bioethics Association - Publications; 22 May 2004.
6. Vogel G. Collaborators split over ethics allegations. Science 2005;310:1100.
7. Song SY. Stem cell research in Korea [letter]. Science 2004;305:944-5.
8. Simerly C, Navara C, Hyun S, et al. Embryogenesis and blastocystdevelopment after somatic cell nuclear transfer in nonhumanprimates: overcoming defects caused by meiotic spindle extraction. Dev Biol 2004;276:237-52.
9. Jin R. Roh aide caught in stem cell scandal. The Korea Times 18 December 2005.
10. Anon. Schatten deeply implicated in Hwang fraud: witness. Digital Chosun Ilbo 16 February 2006. http://english.chosun.com/cgi-bin/ printNews?id = 200602160014 (accessed 17 December 2007).
11. Hwang W-S, Roh SI, Lee BC, et al. Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science 2005; 308:1777-83.
12. Lee BC, Kim MK, Jang G, et al. Dogs cloned from adult somatic cells. Nature 2005;436:641.
13. NewsΝature.com. Timeline of a controversy. Nature; 2005.
14. Holden C. Korean cloner admits lying about oocyte donations. Science 2005;310:1402-3.
15. Chong S, Normile D. How young Korean researchers helped unearth a scandal Science 2006;311:22-5.
16. Vogel G. Landmark paper has an image problem. Science 2005;310:1595.
17. Anon. Mindfully.org. Stem-cell scientist asks for retraction. http://www.mindfully.org/Health/2005/Schatten-Stem-Cel/14dec05.htm (accessed 13 Jan 2008).
18. Wilmut I, Campbell K. Human Embryonic Stem Cells. Science 2005;310:1903.
19. Normile D, Vogel G, Holden C. Cloning researcher says work is flawed but claims results stand. Science 2005;310:1886-7.
20. Bhattacharya S and AFP. Cloning pioneer did fake results. NewScientist 23 Dec 2005. http://www.newscientist.com /article.ns?id = dn8515 (accessed 17 December 2007).
21. Myung-hee C. Summary of the final report on Hwang's research allegation. Seoul National University, 2006. http:// Socrates.berkeley.edu/~scotch/science_policy/snu_report.pdf (accessed 13 Jan 2008).
22. Kim SJ, Cheon SH, Yoe SJ, et al. Contribution of the PI3K/ Akt/PKB signal pathway to maintenance of self-renewal in human embryonic stem cells. FEBS Lett 2005;579:534-40.
23. Reich ES, Hooper R. Cloning crisis goes from bad to worse. NewScientist 20 Dec 2005:4. http://www.newscientist.com /article.ns?id = mg18825313.600 (accessed 20 Dec 2007).
24. englishnewsγhosun.com. Korea's cloning king in stem cell breakthrough. Digital Chosun Ilbo 20 May 2005. http:// english.chosun.com/w21data/html/news/200505/200505190028.html (accessed 12 Jan 2008).
25. Biagioli M, Crane J, Derish P, et al. CSE task force on authorship (draft white paper) 1999. http:// www.councilscienceeditors,org/services/atf_whitepaper.cfm (accessed 17 Dec 2007).
26. Spotts PN. Laboratory ethics: What makes some scientists cheat? Christian Science Monitor 22 Dec 2005. http://www.csmonitor.com /2005/1222/p02s01-stss.html (accessed 17 Dec 2007).
27. Savulescu J, Chalmers I, Blunt J. Are research ethics committees behaving unethically? Some suggestions for improving performance and accountability. BMJ 1996:313:1390-3.
28. Bosman J. Reporters find science journals harder to trust, but not easy to verify. New York Times 13 February 2006.http:// www.nytimes.com/2006/02/13/business/media/13journal.html (accessed 19 December 2007).
29. Government. Section 9 - Integrity of the publishing process; 2004. http://www.publications.parliament.uk/pa/cm200304/cmselect/cmsctech/399/ 39912.htm.
30. Barnes DE. Why review articles on the health effects of passive smoking reach different conclusions. JAMA 1998;279:1566-70.
31. Scanlon C. Korea's national shock at scandal. BBC News, UK version 13 Jan 2006. http://news.bbc.co.uk/1/hi/world/asia-pacific/ 4608838.stm (accessed 19 December 2007).
32. Onishi N. In a country that craved respect, stem cell scientist rode a wave of Korean pride. The New York Times 22 January 2006.
33. Minger DS. The fall of a scientific rock star. BBC News, UK version 10 Jan 2006. http://news.bbc.co.uk/1/hi/sci/tech/4599974.stm (accessed 19 Dec 2007).
34. Weisbart M. [The Nation] Still waiting for cloning debate. The Korea Times, 6 Mar 2006.
35. Anon. Hwang Woo-Suk. Wikipedia 2006. Scanlon C. Korea's national shock at scandal. BBC News, UK version 13 Jan 2005. http://news.bbc.co.uk/1/hi/world/asia-pacific/4608838.stm [accessed 19 December 2007). http://en.wikipedia.org/wiki/Hwang_Woo-Suk (accessed 19 Dec 2007).
36. Anon. Tragedy of fame. Shanghai Star 2005, Press clips.
37. Kim T-G. Hwang targets AIDS cure. The Korea Times 5 Nov 2005.http://www.kuisc.org/Article/view.php?bbs_id = Resource_01&page = &doc_num = 22 (accessed 19 Dec 2007).
38. Kim C-W. Hwang's team in ethical minefield over ova: panel. The Korea Times 2 Feb 2006. Available at http://www.lifeissues.net/ writers/irv/irv_117tragicirony.html (accessed 19 Dec 2007).
39. Magnus D, Cho M. A commentary on oocyte donation for stem cell research in South Korea. Am J Bioeth 2006;6:W23-4.
40. Merz J. Ethics panel head to quit in alleged involvement in Hwang's scandal [summary of a Korean Herald article]. IRB Forum 5 Jan 2006. http://www. irbforum.org/forum/read/2/113/ 113Vt?PHPSESSID=230a474bc7424d4f5ee07fffb85d5ad5
41. Gottweis H, Triendl R. South Korean policy failure and the Hwang debacle. Nat Biotechnol 2006;24:141-3.
42. Jung KW, Hyun I. RETRACTED: Oocyte and somatic cell procurement for stem cell research. Am J Bioeth 2006;6(1):W19.
43. Hyun I, Jung KW. Letter to the editor concerning oocyte and somatic cell procurement for stem cell research. Am J Bioeth 2005:5(6):Wxx. htt://www.bioethics.net/journal/j_articles_php?aid = 88/ (accessed 13 Jan 2008).
44. Bails J, Fabregas L. Lax oversight by Pitt enabled Schatten fiasco. Pittsburgh Tribune-Review 23 April 2006. http:// www.pittsburghlive.com/x/pittsburghtrib/s_446555.html (accessed 19 Dec 2007).
45. Magnus O, Cho M. Issues in oocyte donation for stem cell research. Science 2005;308:1747-8.
46. Hinxton Group. Consensus statement of the Hinxton group, February 24, 2006. http://www.hinxtongroup.org/au_cs.html (accessed 19 Dec 2007).
47. Vogel G, Marshall E. Bias claim stirs up ghost of Dolly. Science 2006:311:1539.
48. Sample I. Who really made Dolly? Tale of British triumph descends into scientists' squabble. The Guardian 11 March 2006. http:// www.guardian.co.uk/science/2006/mar/11/genetics.highereducation1 (accessed 19 Dec 2007).
49. Wade N. Journal to examine how it reviewed articles. The New York Times 11 Jan 2006. http://www.nytimes.com/2006/01/11/science/ 11fraud.html (accessed 19 Dec 2007).
50. Anon. Cloning researcher's reputation tarnished. New Scientist 2006(2539):7.
51. Maris E, Check E. Disgraced cloner's ally is cleared of misconduct. Nature 2006;439:768-9.
52. Gerber P. What can we learn from the Hwang and Sudbø affairs? 2006;184:632-5.
53. Wade N, Choe S-H. Researcher faked evidence of human cloning, Koreans report. The New York Times 10 January 2006. http:// www.nytimes.com/2006/01/10/science/10clone.html (accessed 19 Dec 2007).
54. Anon. Study shows bioethics awareness lacking [editorial]. Dong-a Ilbo (East Asia Daily) 25 November 2005.
55. Savulescu J, Saunders R. The "Hinxton Group" considers transnational stem cell research. The Hastings Centre Report. May/ June 2006:49 [inside back cover].
56. Check JH, Choe JK, Nazari A, et al. Fresh embryo transfer is more effective than frozen for donor oocyte recipients but not for donors. Hum Reprod 2001;16:1403-8.
57. Galpern E. Beyond embryo politics: women's health and dignity in stem cell research. Centre For Genetics and Society, May/June 2006, 4pp. http://www.biopoliticaltimes.org/downloads/Galpern_WHA_0506.pdf (accessed 19 Dec 2007).
58. None accredited. Safety of egg donation 'unclear'. BBC News, UK version 30 Jun 2005. http://news.bbc.co.uk/1/hi/health/4634625.stm (accessed 19 Dec 2007).
59. McGee G. Editorial Retraction. Am J Bioeth 2006; 6(1):W33.
60. Lifton RJ. The Nazi doctors: medical killing and the psychology of genocide. New York: Basic Books, 1986.
61. Gunsalus CK. How to blow the whistle and still have a career afterwards. Sci Eng Ethics 1998;4:51-64.
62. Savulescu J. Thalassaemia major: the murky story of deferiprone. BMJ 2004;328:358-9.
63. Savulescu J. Editor's note: How can we make a difference? The perils of heroism. J Med Ethics 2004;30:52.