Effect of a fungal immunomodulatory protein from Ganoderma tsugae on cell cycle and interferon-gamma production through phosphatidylinositol 3-kinase signal pathway

Process Biochemistry

Volumn 43, Issue 4, 2008, Pages 423-430

  Hsiao, Yi Min ^a   Huang, Yu Lu ^b   Tang, Sheau Chung ^b   Shieh, Gow Jen ^c   Lai, Jing Ying ^a   Wang, Po Hui ^b   Ying, Tsung Ho ^b   Ko, Jiunn Liang ^b  

^a CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Fungal immunomodulatory protein; IFN ; PI 3 kinase

Indexed keywords

CELLS; FLOW CYTOMETRY; FUNGI; PHOSPHORYLATION;

CELL CYCLE; FUNGAL IMMUNOMODULATORY PROTEIN; GANODERMA TSUGAE;

PROTEINS;

ESCHERICHIA COLI; GANODERMA; GANODERMA TSUGAE;

EID: 40649113594     PISSN: 13595113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.procbio.2008.01.005     Document Type: Article

References (31)

1. Ko J.L., Hsu C.I., Lin R.H., Kao C.L., and Lin J.Y. A new fungal immunomodulatory protein, FIP-fve isolated from the edible mushroom, Flammulina velutipes and its complete amino acid sequence. Eur J Biochem 228 (1995) 244-249
2. van der Hem L.G., van der Vliet J.A., Kino K., Hoitsma A.J., and Tax W.J. Ling-Zhi-8: a fungal protein with immunomodulatory effects. Transplant Proc 28 (1996) 958-959
3. Hsu H.C., Hsu C.I., Lin R.H., Kao C.L., and Lin J.Y. Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea. Biochem J 323 Pt 2 (1997) 557-565
4. Tanaka S., Ko K., Kino K., Tsuchiya K., Yamashita A., Murasugi A., et al. Complete amino acid sequence of an immunomodulatory protein, ling zhi-8 (LZ-8). An immunomodulator from a fungus, Ganoderma lucidium, having similarity to immunoglobulin variable regions. J Biol Chem 264 (1989) 16372-16377
5. Kino K., Mizumoto K., Sone T., Yamaji T., Watanabe J., Yamashita A., et al. An immunomodulating protein, Ling Zhi-8 (LZ-8) prevents insulitis in non-obese diabetic mice. Diabetologia 33 (1990) 713-718
6. van der Hem L.G., van der Vliet J.A., Bocken C.F., Kino K., Hoitsma A.J., and Tax W.J. Prolongation of allograft survival with Ling Zhi-8, a new immunosuppressive drug. Transplant Proc 26 (1994) 746
7. Chesler D.A., Dodard C., Lee G.Y., Levy D.E., and Reiss C.S. Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent. J Neurovirol 10 (2004) 57-63
8. Malmgaard L. Induction and regulation of IFNs during viral infections. J Interferon Cytokine Res 24 (2004) 439-454
9. Lafuente M.J., Martin P., Garcia-Cao I., Diaz-Meco M.T., Serrano M., and Moscat J. Regulation of mature T lymphocyte proliferation and differentiation by Par-4. EMBO J 22 (2003) 4689-4698
10. Zhang W., and Liu H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12 (2002) 9-18
11. Srivastava K.K., Batra S., Sassano A., Li Y., Majchrzak B., Kiyokawa H., et al. Engagement of protein kinase C-theta in interferon signaling in T-cells. J Biol Chem 279 (2004) 29911-29920
12. Choudhury G.G. A linear signal transduction pathway involving phosphatidylinositol 3-kinase, protein kinase Cepsilon, and MAPK in mesangial cells regulates interferon-gamma-induced STAT1alpha transcriptional activation. J Biol Chem 279 (2004) 27399-27409
13. Kane L.P., and Weiss A. The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol Rev 192 (2003) 7-20
14. Lin W.H., Hung C.H., Hsu C.I., and Lin J.Y. Dimerization of the N-terminal amphipathic alpha-helix domain of the fungal immunomodulatory protein from Ganoderma tsugae (Fip-gts) defined by a yeast two-hybrid system and site-directed mutagenesis. J Biol Chem 272 (1997) 20044-20048
15. Lin S.B., Li C.H., Lee S.S., and Kan L.S. Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Life Sci 72 (2003) 2381-2390
16. Kimura Y., Taniguchi M., and Baba K. Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22 (2002) 3309-3318
17. Huie C.W., and Di X. Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B Analyt Technol Biomed Life Sci 812 (2004) 241-257
18. Berovic M., Habijanic J., Zore I., Wraber B., Hodzar D., Boh B., et al. Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides. J Biotechnol 103 (2003) 77-86
19. Fraser J.D., and Weiss A. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol Cell Biol 12 (1992) 4357-4363
20. Thompson C.B., Lindsten T., Ledbetter J.A., Kunkel S.L., Young H.A., Emerson S.G., et al. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines. Proc Natl Acad Sci USA 86 (1989) 1333-1337
21. Ward S.G. CD28: a signalling perspective. Biochem J 318 Pt 2 (1996) 361-377
22. Kane L.P., Andres P.G., Howland K.C., Abbas A.K., and Weiss A. Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines. Nat Immunol 2 (2001) 37-44
23. Woscholski R., Dhand R., Fry M.J., Waterfield M.D., and Parker P.J. Biochemical characterization of the free catalytic p110 alpha and the complexed heterodimeric p110 alpha.p85 alpha forms of the mammalian phosphatidylinositol 3-kinase. J Biol Chem 269 (1994) 25067-25072
24. Stein R.C., and Waterfield M.D. PI3-kinase inhibition: a target for drug development?. Mol Med Today 6 (2000) 347-357
25. Beurel E., Kornprobst M., Blivet-Van Eggelpoel M.J., Ruiz-Ruiz C., Cadoret A., Capeau J., et al. GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression. Exp Cell Res 300 (2004) 354-364
26. Kim H.S., Skurk C., Thomas S.R., Bialik A., Suhara T., Kureishi Y., et al. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem 277 (2002) 41888-41896
27. Wang P.H., Hsu C.I., Tang S.C., Huang Y.L., Lin J.Y., and Ko J.L. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-gamma production through p38 mitogen-activated protein kinase signaling pathway. J Agric Food Chem 52 (2004) 2721-2725
28. Seto Y., Nakajima H., Suto A., Shimoda K., Saito Y., Nakayama K.I., et al. Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. J Immunol 170 (2003) 1077-1083
29. Galli E., Cicconi R., Rossi P., Casati A., Brunetti E., and Mancino G. Atopic dermatitis: molecular mechanisms, clinical aspects and new therapeutical approaches. Curr Mol Med 3 (2003) 127-138
30. Lin J.Y., Chen M.L., and Lin B.F. Ganoderma tsugae in vivo modulates Th1/Th2 and macrophage responses in an allergic murine model. Food Chem Toxicol 44 (2006) 2025-2032
31. Lin J.Y., Chen M.L., Chiang B.L., and Lin B.F. Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Int Immunopharmacol 6 (2006) 241-251