The Macromolecular Assembly of Pathogen-Recognition Receptors is Impelled by Serine Proteases, via Their Complement Control Protein Modules

Journal of Molecular Biology

Volumn 377, Issue 3, 2008, Pages 902-913

  Le Saux, Agnès ^a   Ng, Patricia Miang Lon ^a   Koh, Joanne Jing Yun ^a   Low, Diana Hooi Ping ^a,b   Leong, Geraldine E Ling ^a   Ho, Bow ^c   Ding, Jeak Ling ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE MIT ALLIANCE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

innate immunity; pathogen recognition receptor assembly; protein protein interactions; serine proteases; yeast two hybrid method

Indexed keywords

C REACTIVE PROTEIN; CARCINOLECTIN 5; FICOLIN; GALACTOSE; GALAPTIN; PROTEINASE INHIBITOR; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CRAB; ENZYME BINDING; ENZYME INHIBITION; INFECTION; MACROMOLECULE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; YEAST;

CARCINOSCORPIUS ROTUNDICAUDA; MEROSTOMATA;

EID: 40649109724     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.01.045     Document Type: Article

References (38)

1. N. Kairies H.G. Beisel P. Fuentes-Prior R. Tsuda T. Muta S. Iwanaga The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems Proc. Natl Acad. Sci. USA 98 2001 13519 13524
2. S. Iwanaga B.L. Lee Recent advances in the innate immunity of invertebrate animals J. Biochem. Mol. Biol. 38 2005 128 150
3. R. Medzhitov C. Janeway Jr Innate immune recognition: mechanisms and pathways Immunol. Rev. 173 2000 89 97
4. S. Iwanaga The molecular basis of innate immunity in the horseshoe crab Curr. Opin. Immunol. 14 2002 87 95
5. S. Iwanaga S. Kawabata Evolution and phylogeny of defense molecules associated with innate immunity in horseshoe crab Front. Biosci. 3 1998 D973 D984
6. S. Kurata S. Ariki S. Kawabata Recognition of pathogens and activation of immune responses in Drosophila and horseshoe crab innate immunity Immunobiology 211 2006 237 249
7. Y. Zhu S. Thangamani B. Ho J.L. Ding The ancient origin of the complement system EMBO J. 24 2005 382 394
8. J.L. Ding K.C. Tan S. Thangamani N. Kusuma W.K. Seow T.H. Bui Spatial and temporal coordination of expression of immune response genes during Pseudomonas infection of horseshoe crab, Carcinoscorpius rotundicauda Genes Immun. 6 2005 557 574
9. X.W. Wang N.S. Tan B. Ho J.L. Ding Evidence for the ancient origin of the NF-kappaB/IkappaB cascade: its archaic role in pathogen infection and immunity Proc. Natl Acad. Sci. USA 103 2006 4204 4209
10. P.M.L. Ng A. Le Saux C.M. Lee N.S. Tan J. Lu S. Thiel C-reactive protein collaborates with plasma lectins to boost immune response against bacteria EMBO J. 26 2007 3431 3440
11. D. Iwaki T. Osaki Y. Mizunoe S.N. Wai S. Iwanaga S. Kawabata Functional and structural diversities of C-reactive proteins present in horseshoe crab hemolymph plasma Eur. J. Biochem. 264 1999 314 326
12. P.M. Ng Z. Jin S.S. Tan B. Ho J.L. Ding C-reactive protein: a predominant LPS-binding acute phase protein responsive to Pseudomonas infection J. Endotoxin Res. 10 2004 163 174
13. F.A. Robey T.Y. Liu Limulin: a C-reactive protein from Limulus polyphemus J. Biol. Chem. 256 1981 969 975
14. T.H. Kuo S.C. Chuang S.Y. Chang P.H. Liang Ligand specificities and structural requirements of two Tachypleus plasma lectins for bacterial trapping Biochem. J. 393 2006 757 766
15. S.T. Chiou Y.W. Chen S.C. Chen C.F. Chao T.Y. Liu Isolation and characterization of proteins that bind to galactose, lipopolysaccharide of Escherichia coli , and protein A of Staphylococcus aureus from the hemolymph of Tachypleus tridentatus J. Biol. Chem. 275 2000 1630 1634
16. J.L. Ding B. Ho A new era in pyrogen testing Trends Biotechnol. 19 2001 277 281
17. N.S. Tan B. Ho J.L. Ding High-affinity LPS binding domain(s) in recombinant factor C of a horseshoe crab neutralizes LPS-induced lethality FASEB J. 14 2000 859 870
18. N.S. Tan M.L. Ng Y.H. Yau P.K. Chong B. Ho J.L. Ding Definition of endotoxin binding sites in horseshoe crab factor C recombinant sushi proteins and neutralization of endotoxin by sushi peptides FASEB J. 14 2000 1801 1813
19. A. Li P.Y. Lee B. Ho J.L. Ding C.T. Lim Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria Biochim. Biophys. Acta 1768 2007 411 418
20. C. Li M.L. Ng Y. Zhu B. Ho J.L. Ding Tandem repeats of Sushi3 peptide with enhanced LPS-binding and -neutralizing activities Protein Eng. 16 2003 629 635
21. P. Li M. Sun B. Ho J.L. Ding The specificity of Sushi peptides for endotoxin and anionic phospholipids: potential application of POPG as an adjuvant for anti-LPS strategies Biochem. Soc. Trans. 34 2006 270 272
22. P. Li M. Sun T. Wohland B. Ho J.L. Ding The molecular mechanism of interaction between sushi peptide and Pseudomonas endotoxin Cell. Mol. Immunol. 3 2006 21 28
23. P. Li M. Sun T. Wohland D. Yang B. Ho J.L. Ding Molecular mechanisms that govern the specificity of Sushi peptides for Gram-negative bacterial membrane lipids Biochemistry 45 2006 10554 10562
24. P. Li T. Wohland B. Ho J.L. Ding Perturbation of lipopolysaccharide (LPS) micelles by Sushi 3 (S3) antimicrobial peptide. The importance of an intermolecular disulfide bond in S3 dimer for binding, disruption, and neutralization of LPS J. Biol. Chem. 279 2004 50150 50156
25. L. Wang B. Ho J.L. Ding Transcriptional regulation of limulus factor C: repression of an NFkappaB motif modulates its responsiveness to bacterial lipopolysaccharide J. Biol. Chem. 278 2003 49428 49437
26. S. Ariki K. Koori T. Osaki K. Motoyama K. Inamori S. Kawabata A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides Proc. Natl Acad. Sci. USA 101 2004 953 958
27. A. Ichinose R.E. Bottenus E.W. Davie Structure of transglutaminases J. Biol. Chem. 265 1990 13411 13414
28. C. Gaboriaud V. Rossi J.C. Fontecilla-Camps G.J. Arlaud Evolutionary conserved rigid module-domain interactions can be detected at the sequence level: the examples of complement and blood coagulation proteases J. Mol. Biol. 282 1998 459 470
29. Y. Le S.H. Lee O.L. Kon J. Lu Human L-ficolin: plasma levels, sugar specificity, and assignment of its lectin activity to the fibrinogen-like (FBG) domain FEBS Lett. 425 1998 367 370
30. Y. Le S.M. Tan S.H. Lee O.L. Kon J. Lu Purification and binding properties of a human ficolin-like protein J. Immunol. Methods 204 1997 43 49
31. W.S. Rasband ImageJ 1997–2007 US National Institutes of Health Bethesda, MD, USA
32. N. Jiang N.S. Tan B. Ho J.L. Ding Respiratory protein-generated reactive oxygen species as an antimicrobial strategy Nat. Immunol. 8 2007 1114 1122
33. J. Wang N.S. Tan B. Ho J.L. Ding Modular arrangement and secretion of a multidomain serine protease. Evidence for involvement of proline-rich region and N-glycans in the secretion pathway J. Biol. Chem. 277 2002 36363 36372
34. S. Kawabata F. Tokunaga Y. Kugi S. Motoyama Y. Miura M. Hirata S. Iwanaga Limulus factor D, a 43-kDa protein isolated from horseshoe crab hemocytes, is a serine protease homologue with antimicrobial activity FEBS Lett. 398 1996 146 150
35. M.J. Lehtinen S. Meri T.S. Jokiranta Interdomain contact regions and angles between adjacent short consensus repeat domains J. Mol. Biol. 344 2004 1385 1396
36. T. Muta T. Miyata Y. Misumi F. Tokunaga T. Nakamura Y. Toh Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains J. Biol. Chem. 266 1991 6554 6561
37. D.G. Norman P.N. Barlow M. Baron A.J. Day R.B. Sim I.D. Campbell Three-dimensional structure of a complement control protein module in solution J. Mol. Biol. 219 1991 717 725
38. R.H. Schiestl R.D. Gietz High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier Curr. Genet. 16 1989 339 346