Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an "in vitro" model

Journal of Medical Virology

Volumn 80, Issue 4, 2008, Pages 741-745

  Bertelli, A A E ^a   Mannari, C ^b   Santi, S ^b   Filippi, C ^b   Migliori, M ^c   Giovannini, L ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c Versilia Hospital   (Italy)

Author keywords

Immunity; Interleukins; Quercitin; Shikimic acid; Tamiflu

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; OSELTAMIVIR; QUERCETIN; SHIKIMIC ACID;

ARTICLE; AVIAN INFLUENZA; COMBINATION CHEMOTHERAPY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; MONOTHERAPY; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; UPREGULATION;

HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; INTERLEUKIN-8; LEUKOCYTES, MONONUCLEAR; OSELTAMIVIR; QUERCETIN; SHIKIMIC ACID;

AVES;

EID: 40549143417     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21072     Document Type: Article

References (39)

1. Apostolopoulos J, Davenport P, Tipping PG. 1996. Interleukin-8 production by macrophages from atheromatous plaques. Arterioscl Thromb Vasc Biol 16:1007-1012.
2. Baggiolini M, Loetscher P, Moser B. 1995: Interleukin-8 and the chemokine family. Int J Immunopharmacol 17:103-108.
3. Barak V, Halperin T, Kalickman I. 2001. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 12:290-296.
4. Barak V, Birkenfeld S, Halperin T, Kalickman I. 2002. The effect of herbal remedies on the production of human inflammatory and anti-inflammatory cytokines. Isr Med Assoc J 4:919-922.
5. Barton BE, Shortall J, Jackson JV. 1996. Interleukins 6 and 11 protect mice from mortality in a staphylococcal enterotoxin-induced toxic shock model. Infect Immun 64:714-718.
6. Bertelli AA. 2006. Stockpiling of raw material for oseltamivir is not justified. BMJ 332:178.
7. Bertelli AA, Giovannini L, Stradi R, Bertelli A, Tillement JP. 1996. Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4′,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats. Int J Tissue React 18:67-71.
8. Bertelli AA, Migliori M, Panichi V, Longoni B, Origlia N, Ferretti A, Cuttano MG, Giovannini L. 2002. Oxidative stress and inflammatory reaction modulation by white wine. Ann NY Acad Sci 957:295-301.
9. Bowdish DM, Davidson DJ, Scott MG, Hancock RE. 2005. Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother 49:1727-1732.
10. Bradley D. 2005. Star role for bacteria in controlling flu pandemic? Nat Rev Drug Discov 4:945-946.
11. Cribier B, Schmitt C, Rey D, Lang JM, Kirn A, Stoll-Keller F. 1998. Production of cytokines in patients infected by hepatitis C virus. J Med Virol 55:89-91.
12. Denis M. 1992. Interleukin-6 in mouse hypersensitivity pneumonitis: Changes in lung free cells following depletion of endogenous IL-6 or direct administration of IL-6. J Leukoc Biol 52:197-201.
13. El-Seedi HR, Ringbom T, Torssell K, Bohlin L. 2003. Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities. Chem Pharm Bull 51:1439-1440.
14. Emmerich B, Pachmann K, Milatovic D, Emslander HP. 1992. Influence of OM-85 BV on different humoral and cellular immune defence mechanisms of the respiratory tract. Respiration 59:19-23.
15. Falchi M, Bertelli A, Lo Scalzo R, Morassut M, Morelli R, Das S, Cui J, Das DK. 2006. Comparison of cardioprotective abilities between the flesh and skin of grapes. J Agric Food Chem 54:6613-6622.
16. Goldberg DM, Yan J, Soleas GJ. 2003. Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin Biochem 36:79-87.
17. Huang F, Xiu Q, Sun J, Hong E. 2002. Anti-platelet and antithrombotic effects of triacetylshikimic acid in rats. J Cardiovasc Pharmacol 39:262-270.
18. Huber AR, Kunkel SL, Todd RF III, Weiss SJ. 1991. Regulation of transendothelial neutrophil migration by endogenous interleukin-8. Science 254:99-102.
19. Ize-Ludlow D, Ragone S, Bruck IS, Bernstein JN, Duchowny M, Pena BM. 2004. Neurotoxicities in infants seen with the consumption of star anise tea. Pediatrics 114:e653-e656; Epub Oct 18.
20. Kamara BI, Brand DJ, Brandt EV, Joubert E. 2004. Phenolic metabolites from honeybush tea (Cyclopia subternata). J Agric Food Chem 52:5391-5395.
21. Keul R, Roth M, Papakonstantinou E, Nauck M, Perruchoud AP, Block LH. 1996. Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element. Thorax 51:150-154.
22. Kramer M, Bongaerts J, Bovenberg R, Kremer S, Muller U, Orf S, Wubbolts M, Raeven L. 2003. Metabolic engineering for microbial production of shikimic acid. Metab Eng 5:277-283.
23. Lanzilli G, Falchetti R, Tricarico M, Ungheri D, Fuggetta MP. 2005. In vitro effects of an immunostimulating bacterial lysate on human lymphocyte function. Int J Immunopathol Pharmacol 18:245-254.
24. Ma Y, Xu QP, Sun JN, Bai LM, Guo YJ, Niu JZ. 1999. Antagonistic effects of shikimic acid against focal cerebral ischemia injury in rats sujected to middle cerebral artery thrombosis. Acta Pharm Sin 20:701-704.
25. Mauel J. 1992. Macrophage activation by OM-85 BV. Respiration 59:14-18.
26. Mauel J. 1994. Stimulation of immunoprotective mechanisms by OM-85 BV. A review of results from in vivo and in vitro studies. Respiration 61:8-15.
27. Minodier P, Pommier P, Moulene E, Retornaz K, Prost N, Deharo L. 2003. Star anise poisoning in infants. Arch Pediatr 10:619-621.
28. Mudur G. 2006. Indian firm to produce oseltamivir for developing countries. BMJ 332:5.
29. Oxford JS, Mann A, Lambkin R. 2003. A designer drug against influenza: The NA inhibitor oseltamivir (Tamiflu). Expert Rev Anti Infect Ther 1:337-342.
30. Rollins BJ, Yoshimura T, Leonard EJJ, Pober S. 1990. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am J Pathol 136:1229-1233.
31. Roth M, Block LH. 2000. Distinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines. Thorax 55:678-684.
32. Scott MG, Davidson DJ, Gold MR, Bowdish D, Hancock RE. 2002. The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol 169:3883-3891.
33. Tsan M, White J, Del Vecchio P, Shaffer J. 1991. IL-6 enhances TNF-alpha and IL-1 induced increase in superoxide dismutase mRNA and O2 tolerance. Am J Physiol 138:L22-L26.
34. Ulich T, Yin S, Guo K, Yin E, Remick D, del Castillo J. 1991. Intratracheal injection of endotoxin and cytokines. II. IL-6 and transforming growth factor beta inhibit acute inflammation. Am J Physiol 138:97-101.
35. Weinberg J. 2005. Star anise is handy in the kitchen, too. The Times, November 1.
36. Xu L, Kelvin DJ, Ye GQ, Taub DD, Ben-Baruch A, Oppenheim J, JWang JM. 1995. Modulation of IL-8 receptor expression on purified human T lymphocytes is associated with changed chemotactic responses to IL-8. J Leuk Biol 57:335-342.
37. Yamanaka T, Tsujimura K, Kondo T, Matsumura T. 2006. In vitro efficacies of oseltamivir carboxylate and zanamivir against equine influenza A viruses. J Vet Med Sci 68:405-408.
38. Yang D, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O. 2000. LL-37, the neutrophil granule-and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 192:1069-1074.
39. Zhang J, Wang Q, Fang H, Xu W, Liu A, Du G. 2007. Design, synthesis, inhibitory activity, and SAR studies of pyrrolidine derivatives as neuraminidase inhibitors. Bioorg Med Chem 15:2749-2758.