Transgenic mice replicating hepatitis B virus but lacking expression of the major HBsAg

Journal of Medical Virology

Volumn 80, Issue 4, 2008, Pages 583-590

  Halverscheid, Leonie ^a   Mannes, Nina K ^a   Weth, Robert ^a   Kleinschmidt, Manuela ^a   Schultz, Ursula ^a   Reifenberg, Kurt ^b   Schirmbeck, Reinhold ^c   Nassal, Michael ^a   Blum, Hubert E ^a   Reimann, Jörg ^c   Geissler, Michael ^a,d  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d Hospital Esslingen   (Germany)

Author keywords

HBV replication; Immune response; Tolerance

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; MESSENGER RNA; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VIRUS RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; ENDOPLASMIC RETICULUM; FEMALE; GENDER; GENETIC MODEL; GROUPS BY AGE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; IMMUNOPATHOGENESIS; KIDNEY; LIVER; LIVER CELL; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; SERODIAGNOSIS; TRANSGENIC MOUSE; VIRUS ASSEMBLY; VIRUS IMMUNITY; VIRUS PARTICLE; VIRUS REPLICATION;

AGE FACTORS; ANIMALS; ENDOPLASMIC RETICULUM; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; KIDNEY; LIVER; MICE; MICE, TRANSGENIC; RNA, MESSENGER; RNA, VIRAL; SERUM; SEX FACTORS; VIRAL ENVELOPE PROTEINS; VIRION; VIRUS REPLICATION;

HEPATITIS B VIRUS; MUS; MUS MUSCULUS;

EID: 40549096389     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21115     Document Type: Article

References (23)

1. Chisari FV. 1999. The immunobiology of viral hepatitis. In: Crispe N, editor. T Lymphocytes in the liver: Immunobiology, pathology, and host defense. New York: Wiley-Liss, Inc. pp 117-138.
2. Chisari FV, Filippi P, McLachlan A, Milich DR, Riggs M, Lee S, Palmiter RD, Pinkert CA, Brinster RL. 1986. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol 60:880-887.
3. Chisari FV, Filippi P, Buras J, McLachlan A, Popper H, Pinkert CA, Palmiter RD, Brinster RL. 1987. Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proc Natl Acad Sci USA 84:6909-6913.
4. Geissler M, Tokushige K, Chante CC, Zurawski VR, Wands JR. 1997. Cellular and humoral immune response to hepatitis B virus structural proteins in mice after DNA-based immunization. Gastroenterology 112:1307-1320.
5. Geissler M, Bruss V, Michalak S, Ortmann D, Wands JR, Blum. HE. 1999. Intracellular retention of hepatitis B virus surface proteins reduces the immune response augmenting effects of IL-2 after cytokine genetic coimmunizations. J Virol 73:4284-4292.
6. Gilles PN, Guerrette DL, Ulevitch RJ, Schreiber RD, Chisari FV. 1992. HBsAg retention sensitizes the hepatocyte to injury by physiological concentrations of interferon-gamma. Hepatology 16:655-663.
7. Guidotti LG, Matzke B, Schaller H, Chisari FV. 1995. High-level hepatitis B virus replication in transgenic mice. J Virol 69:6158-6169.
8. Heermann KH, Goldmann U, Schwartz W, Seyffarth T, Baumgarten H, Gerlich WH. 1984. Large surface proteins of hepatitis B virus containing the pre-s sequence. J Virol 52:396-402.
9. Heermann KH, Kruse F, Seifer M, Gerlich WH. 1987. Immunogenicity of the S and Pre-S gene domains in hepatitis B virions and HBsAg filaments. Intervirology 28:14-25.
10. Kakimi K, Isogawa M, Chung J, Sette A, Chisari FV. 2002. Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: Implications for immunotherapy of persistent viral infections. J Virol 76:8609-8620.
11. b mice. J Immunol 156:3687-3695.
12. Melegari M, Scaglioni PP, Wands JR. 1998. Cloning and characterization of a novel hepatitis B virus x binding protein that inhibits viral replication. J Virol 72:1737-1743.
13. Michel ML, Davis HL, Schleef M, Mancini M, Tiollais P, Whalen RG. 1995. DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci USA 92:5307-5311.
14. Milich DR. 2000. Transgenic technology and the study of hepatitis viruses: A review of what we have learned. Can J Gastroenterol 14:781-787.
15. Okuda K. 2000. Hepatocellular carcinoma. J Hepatol 32:225-237.
16. Reifenberg K, Lohler J, Pudollek HP, Schmitteckert E, Spindler G, Köck J, Schlicht HJ. 1997. Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice. J Hepatol 26:119-130.
17. Reifenberg K, Nusser P, Lohler J, Spindler G, Kuhn C, von Weizsäcker F, Köck. J. 2002. Virus replication and virion export in X-deficient hepatitis B virus transgenic mice. J Gen Viro 83:991-996.
18. Schirmbeck R, Bohm W, Ando K, Chisari FV, Reimann J. 1995. Nucleic acid vaccination primes hepatitis B virus surface antigen- specific cytotoxic T lymphocytes in nonresponder mice. J Virol 69:5929-5934.
19. Schirmbeck R, Wild J, Blum HE, Chisari FV, Geissler M, Reimann J. 2000. Ongoing T1 or T2 immune responses to the hepatitis B surface antigen (HBsAg) are excluded from the liver of mice in which transgene-encoded HBsAg is expressed. J Immunol 164:4235-4243.
20. Shimizu Y, Guidotti LG, Fowler P, Chisari FV. 1998. Dendritic cell immunization breaks cytotoxic T lymphocyte tolerance in hepatitis B virus transgenic mice. J Immunol 161:4520-4529.
21. 2000. posting date. Hepatitis B Fact sheet WHO/204. Geneva: World Health Organization, October 2000 (http://www.who.int/inf-fs/en/ fact204.htm). [Online.]
22. Wirth S, Guidotti LG, Ando K, Schlicht HJ, Chisari FV. 1995. Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice. J Immunol 154:2504-2515.
23. Xu Z, Bruss V, Yen. B. 1997. Formation of intracellular particles by hepatitis B virus large surface protein. J Virol 71:5478-5494.