A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia

Pediatric Blood and Cancer

Volumn 50, Issue 4, 2008, Pages 869-871

  Alonso, Cristina N ^a   Rubio Longo, Patricia L ^a   Gallego, Marta S ^a   Medina, Adriana ^a   Felice, María S ^a  

^a HOSPITAL DE PEDIATRÍA PROF DR JUAN P GARRAHAN   (Argentina)

Author keywords

AML; Infant; MLL AF9; MLLT3; Novel breakpoint; T(9 ; 11)

Indexed keywords

ACUTE MONOCYTIC LEUKEMIA; AF9 GENE; ARTICLE; CASE REPORT; CHILDHOOD LEUKEMIA; FEMALE; FOLLOW UP; GENE; GENE REARRANGEMENT; HUMAN; INFANT; MINIMAL RESIDUAL DISEASE; MLL GENE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

FEMALE; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; ONCOGENE PROTEINS, FUSION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 40449142833     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.21393     Document Type: Article

References (25)

1. Smith FO, Alonzo TA, Gerbing RB, et al. Long-term results of children with acute myeloid leukemia: A report of three consecutive Phase III trials by the Children's Cancer Group: CCG251 CCG213 and C CG2891. Leukemia 2005;19:2054-2062.
2. Creutzig U, Zimmermann M, Ritter J, et al. Treatment strategies and long-term results in paediatric patients treated in four consecutive AML-BFM trials. Leukemia 2005;19:2030-2042.
3. Ravindranath Y, Chang M, Steuber CP, et al. Pediatric Oncology Group (POG) studies of acute myeloid leukemia (AML): A review of four consecutive childhood AML trials conducted between 1981 and 2000. Leukemia 2005;19:2101-2116.
4. Langer T, Metzler M, Reinhardt D, et al. Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy-related AML after treatment without etoposides. Genes Chromosomes Cancer 2003;36:393-401.
5. Pieters R, Schrappe M, De Lorenzo P, et al. A treatment protocol for infants younger than 1 year with acute lymphoblastic leukaemia (Interfant-99): An observational study and a multicentre randomised trial. Lancet 2007;369:1-11.
6. Rubnitz JE, Raimondi SC, Tong J, et al. Favorable impact of the t(9;11) in Childhood Acute Myeloid Leukemia. J Clin Oncol 2002;20:2302-2309.
7. Pui CH, Gaynon PS, Boyett JM, et al. Outcome of treatment in childhood acute lymphoblastic leukaemia with rearrangements of the 11q23 chromosomal region. Lancet 2002;359:1909-1915.
8. Nilson I, Löchner K, Siegler G, et al. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. Br J Haematol 1996;93:966-972.
9. Strissel PL, Strick R, Tomek RJ, et al. DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Hum Mol Genet 2000;9:1671-1679.
10. Nakamura T, Alder H, Gu Y, et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs. Proc Natl Acad Sci USA 1993;90:4631-4635.
11. Mitterbauer G, Zimmer C, Fonatsch C, et al. Monitoring of minimal residual leukemia in patients with MLL-AF9 positive acute myeloid leukemia by RT-PCR. Leukemia 1999;13:1519-1524.
12. Poirel H, Rack K, Delabesse E, et al. Incidence and characterization of MLL gene (11q23) rearrangements in acute myeloid leukemia M1 and M5. Blood 1996;87:2496-2505.
13. Scholl C, Breitinger H, Schlenk RF, et al. Development of a real-time RT-PCR assay for the quantification of the most frequent MLL/AF9 fusion types resulting from translocation t(9;11) (p22;q23) in acute myeloid leukemia. Genes Chromosomes Cancer 2003;38:274-280.
14. Jansen MWJC, van der Velden VHJ, van Dongen JJM. Efficient and easy detection of MLL-AF4, MLL-AF9 and MLL-ENL fusion gene transcripts by multiplex real-time quantitative RT-PCR in TaqMan and LightCycler. Leukemia 2005;19:2016-2018.
15. Gill Super H, Strissel P, Sobulo O, et al. Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia. Genes Chromosomes Cancer 1997;20:185-195.
16. Ida K, Taki T, Bessho F, et al. Detection of chimeric mRNAs by reverse transcriptase-polymerase chain reaction for diagnosis and monitoring of acute leukemias with 11q23 abnormalities. Med Pediatr Oncol 1997;28:325-332.
17. Atlas M, Head D, Behm F, et al. Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints. Leukemia 1998;12:1895-1902.
18. Shago M, Bouman D, Kamel-Reid S, et al. Cryptic insertion of MLL gene into 9p22 leads to MLL-MLLT3 (AF9) fusion in a case of acute myelogenous leukemia. Genes Chromosomes Cancer 2004;40:349-354.
19. Negrini M, Felix CA, Martin C, et al. Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia. Cancer Res 1993;53:4489-4492.
20. Andersson A, Höglund M, Johansson B, et al. Paired multiplex reverse-transcriptase polymerase chain reaction (PMRT-PCR) analysis as a rapid and accurate diagnostic tool for the detection of MLL fusion genes in hematologic malignancies. Leukemia 2001;15:1293-1300.
21. Strehl S, König M, Mann G, et al. Multiplex reverse transcriptase-polymerase chain reaction screening in childhood acute myeloblasts leukemia. Blood 2001;97:805-808.
22. Meyer C, Schneider B, Reichel M, et al. Diagnostic tool for the identification of MLL rearrangements including unknown partner genes. Proc Natl Acad Sci USA 2005;102:449-454.
23. Van Dongen JJM, Macintyre EA, Gabert JA, et al. Report of BIOMED-1 Concerted Action. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Leukemia 1999;13:1901-1928.
24. Pallisgaard N, Hokland P, Riishøj DC, et al. Multiplex reverse transcription-polymerase chain reaction for simultaneous screening of 29 translocations and chromosomal aberrations in acute leukemia. Blood 1998;92:574-588.
25. Shaffer LG, Tommerup N, editors. ISCN. An International System for Human Cytogenetic Nomenclature. Basel, Switzerland: S. Karger 2005.