Effects of topical DHEA on aging skin: A pilot study

Maturitas

Volumn 59, Issue 2, 2008, Pages 174-181

  Nouveau, Stéphanie ^a   Bastien, Philippe ^a   Baldo, Francine ^a   de Lacharriere, Olivier ^a  

^a L ORÉAL RECHERCHE   (France)

Author keywords

Aging; DHEA; Skin; Topical treatment

Indexed keywords

PRASTERONE;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; ENDOCRINE FUNCTION; EPIDERMIS; FACE; FEMALE; HAND; HUMAN; MENOPAUSE; NORMAL HUMAN; PHOTOAGING; PILOT STUDY; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; SEBUM SECRETION; SKIN ATROPHY; SKIN COLOR; SKINFOLD THICKNESS; WRINKLE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, TOPICAL; AGED; ATROPHY; DEHYDROEPIANDROSTERONE; DOUBLE-BLIND METHOD; EPIDERMIS; FEMALE; HUMANS; MIDDLE AGED; PILOT PROJECTS; SEBUM; SKIN; SKIN AGING;

EID: 40449140693     PISSN: 03785122     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.maturitas.2007.12.004     Document Type: Article

References (36)

1. Orentreich N., Brind J.L., Rizer R.L., and Vogelman J.H. Age changes and sex differences in serum DHEAS concentrations throughout adulthood. J Clin Endocrinol Metab 59 (1984) 551-555
2. Orentreich N., Brind J.L., Vogelman J.H., Andres R., and Baldwin H. Long term longitudinal measurements of plasma DHEAS in normal men. J Clin Endocrinol Metab 75 (1992) 1002-1004
3. Thomas G., Frenoy N., Legrain S., Sebag-Lanoe R., Baulieu E.E., and Debuire B. Serum DHEAS levels as an individual marker. J Clin Endocrinol Metab 79 (1992) 1273-1276
4. Baulieu E.E. Dehydroepiandrosterone (DHEA): a fountain of youth?. J Clin Endocrinol Metab 81 (1996) 3147-3151
5. Legrain S., Berr C., Frenoy N., Gourlet V., Debuire B., and Baulieu E.E. DHEAS in a long term care aged population. Gerontology 41 (1995) 343-351
6. Morales A.J., Nolan J.J., Nelson J.C., and Yen S.C. Effects of replacement dose of DHEA in men and women of advancing age. J Clin Endocrinol Metab 78 (1994) 1360-1367
7. Casson P.R., and Carson S.A. Androgen replacement therapy in women: myths and realities. Int J Fertil 4 (1996) 412-422
8. Toth I., and Faredin I. Concentrations of androgens and C19 steroid sulfates in abdominal skin of healthy women and men. Acta Med Hung 42 (1985) 13-20
9. Baulieu E.E., Thomas G., Legrain S., et al. Dehydroepiandrosterone (DHEA), DHEA sulfate and aging: contribution to a sociobiomedical issue. Proc Natl Acad Sci 97 (2000) 4279-4284
10. Nouveau-Richard S., Tardy I., Triller R., Bastien P., de Prost Y., and de Lacharrière O. Skin aging: clinical parameters for estimated age. Ann Dermatol Venereol 129 (2002) 1S403
11. de Lacharrière O., de Rigal J., Bodomer C., et al. The skin of kidney transplant recipients on long-term systemic corticosteroid therapy is improved by a two-month course of topical all-trans retinoic acid. Eur J Dermatol 4 (1994) 563-568
12. Griffiths C.E., Wang T.S., Hamilton T.A., Voorhees J.J., and Ellis C.N. A photonumeric scale for the assessment of cutaneous photodamage. Arch Dermatol 128 (1992) 347-351
13. Kligman A.M., Miller D.L., and McGinley K.J. A device for visualizing and measuring human sebaceous secretion. J Soc Cosmet Chem 37 (1986) 369
14. de Rigal J., Escoffier C., Querleux B., Faivre B., Agache P., and Lévêque J.L. Assessment of aging of the human skin by in vivo ultrasonic imaging. J Invest Dermatol 93 (1989) 621-625
15. Nouveau-Richard S., Monot M., Bastien P., and de Lacharrière O. In vivo epidermal thickness measurement: ultrasound vs. confocal imaging. Skin Res Tech 10 (2004) 136-140
16. Blichman C.W., and Serup J. Assessment of skin moisture. Acta Dermatol Venereol 68 (1988) 284-290
17. Andreassi L., Casini L., Simoni S., Bartalini P., and Fimiani M. Measurement of cutaneous color and assessment of skin type. Photodermatol Photoimmunol Photomed 7 (1990) 20-24
18. Corcuff P., and Lévêque J.L. Skin surface replica, analysis of furrows and wrinkles. In: Serup J., and Jemec J.B.E. (Eds). Handbook of non-invasive methods and the skin (1995), CRC Press Inc., Boca Raton 89-96
19. Goldzieher M.A. The direct effect of steroids on the senile human skin. J Gerontol 4 (1949) 104-112
20. Creidi P., Faivre B., Agache P., Richard E., Haudiquet V., and Sauvanet J.P. Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin. A comparative study with a placebo cream. Maturitas 19 (1994) 211-223
21. Maheux R., Naud F., Rioux M., et al. A randomized double blind placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol 170 (1994) 642-649
22. Oikarinen A. Systemic estrogens have no conclusive beneficial effect on human skin connective tissue. Acta Obstet Gynecol Scand 79 (2000) 250-254
23. Hall G., and Phillips T.J. Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. J Am Acad Dermatol 53 (2005) 555-568
24. Sauerbronn A.V.D., Fonseca A.M., Bagnoli V.R., Saldiva P.H., and Pinotti J.A. The effects of systemic hormonal replacement therapy on the skin of postmenopausal women. Int J Gynecol Obstet 68 (2000) 35-41
25. Sator P.G., Sator M.O., Schmidt J.B., et al. A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women. Climacteric 10 (2007) 320-334
26. Brincat M., Moniz C.J., Studd J.W.W., et al. Long-term effects of the menopause and sex hormones on skin thickness. Br J Obstet Gynecol 92 (1985) 256-259
27. Varila E., Rantala I., Oikarinen A., et al. The effect of topical oestradiol on skin collagen of postmenopausal women. Br J Obstet Gynecol 102 (1995) 985-989
28. Punnonen R., Vilska S., and Rauramo L. Skinfold thickness and long-term post-menopausal hormone therapy. Maturitas 5 (1984) 259-262
29. Piérard G.E. Rate and topography of follicular sebum excretion. Dermatologica 175 (1987) 280-283
30. Maes D.H., and Marenus K.D. Main finished products: moisturizing and cleansing creams. In: Baran R., and Maibach H.I. (Eds). Textbook of cosmetic dermatology (1998), Martin Dunitz Ltd., London 113-124
31. Richard S., de Lacharrière O., Rougeot M.A., de Rigal J., Lévêque J.L., and Rouaud J.P. Modifications cutanées post-ménopausiques et ostéodensitométrie. Nouv Dermatol 15S (1996) 22
32. Papa C.M. Effect of topical hormones on aging human skin. J Soc Cosmet Chem 18 (1967) 549-562
33. Girard P., Goujon C., Berry N., Girard F., Violin L., and Cohen-Letessier A. Evaluation histologique, biométrologique et clinique de l'effet de la crème Fadiamone contre excipient sur le vieillissement cutané du visage. Etude en double aveugle sur 2 groupes de femmes menopauses. Nouv Dermatol 14 (1995) 448-458
34. Labrie F., Bélanger A., Bélanger P., et al. Metabolism of DHEA in postmenopausal women following percutaneous administration. J Steroid Biochem Mol Biol 103 (2007) 178-188
35. Waller J.M., and Maibach H.I. Age and skin structure and function, a quantitative approach (II): protein, glycosaminoglycan, water, and lipid content and structure. Skin Res Technol 12 (2006) 145-154
36. Shin M.H., Rhie G.E., Park Ch., et al. Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin. J Invest Dermatol 124 (2005) 315-323