Systemic estrogens have no conclusive beneficial effect on human skin connective tissue

Acta Obstetricia et Gynecologica Scandinavica

Volumn 79, Issue 4, 2000, Pages 250-254

  Oikarinen, Aarne ^a,b  

^a UNIVERSITY OF OULU   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

Author keywords

Aging of the skin; Collagen synthesis; Elastin; Estrogens; Skin thickness

Indexed keywords

COLLAGEN; ELASTIN; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; GESTAGEN; GLYCOSAMINOGLYCAN; HYDROXYPROLINE; NORETHISTERONE;

ADULT; AGED; COLLAGEN SYNTHESIS; CONNECTIVE TISSUE; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; HUMAN; MENOPAUSE; NORMAL HUMAN; PRIORITY JOURNAL; SHORT SURVEY; SKINFOLD THICKNESS; ULTRAVIOLET RADIATION;

AGED; AGING; COLLAGEN; CONNECTIVE TISSUE; ELASTIN; FEMALE; HORMONE REPLACEMENT THERAPY; HUMANS; MIDDLE AGED; POSTMENOPAUSE; SKIN PHYSIOLOGY;

EID: 0034100696     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0412.2000.079004250.x     Document Type: Short Survey

References (25)

1. Hasselquist MB, Goldber N, Schroeter A, Spelsberg TC. Isolation and characterization of the estrogen receptor in human skin. J Clin Endocrinol Metab 1980; 50: 76-82.
2. Schmidt JB, Lindmaier A, Spona J. Hormone receptors in pubic skin of premenopausal and postmenopausal females. Gynecol Obstet Invest 1990; 30: 97-100.
3. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889-95.
4. Utian WH. Biosynthesis and physiologic effects of estrogen and pathophysiologic effects of estrogen deficiency: a review. Am J Obstet Gynecol 1989; 161: 1828-31.
5. Brincat M, Moniz CF, Studd JWW, Darby AJ, Magos A, Cooper D. Sex hormone and skin collagen content in postmenopausal women. Br Med J 1983; 287: 1337-8.
6. Brincat M, Versi E, Moniz CF, Magos A, de Trafford J, Studd JWW. Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy. Obstet Gynecol 1987; 70: 123-7.
7. Brincat M, Moniz CF, Kablan S, Versi E, O'Dowd T, Magos AL et al. Decline in skin collagen content and metacarpal index after the menopause and its prevention with sex hormone replacement. Br J Obstet Gynaecol 1987; 94: 126-9.
8. Uitto J, Fazio MJ. Biology and pathology of the extracellular matrix in dermis. In: Soter NA, Baden HP, eds. Pathophysiology of Dermatologic Diseases, 2nd edn. New York: McGraw-Hill, 1990; 349-67.
9. Autio P, Risteli J, Haukipuro K, Risteli L, Oikarinen A. Collagen synthesis in human skin in vivo: modulation by aging, ultraviolet B irradiation and localization. Photodermatol Photoimmunol Photomed 1994; 11: 1-5.
10. Oikarinen A, Autio P, Kiistala U, Risteli L, Risteli J. A new method to measure type I and III collagen synthesis in human skin in vivo: demonstration of decreased collagen synthesis after topical glucocorticoid treatment. J Invest Dermatol 1992; 98: 220-5.
11. Autio P, Oikarinen A, Melkko J, Risteli J, Risteli L. Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect. Br J Dermatol 1994; 131: 660-3.
12. Canalis E, Raisz LG. Effect of sex steroids on bone collagen synthesis in vitro. Calcif Tiss Res 1978; 25: 105-10.
13. Woessner JF. Total, latent and active collagenase during the course of postpartum involution of the rat uterus. Effect of oestradiol. Biochem J 1979; 180: 95-102.
14. Falanga V, Greenberg AS, Zhou L, Ochoa SM, Roberts AB, Falabella A et al. Stimulation of collagen synthesis by the anabolic steroid stanozolol. J Invest Dermatol 1998; 111: 1193-7.
15. Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J et al. A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol 1994: 170: 642-9.
16. Castelo-Branco C, Duran M, Gonzáles-Merlo J. Skin collagen changes related to age and hormone replacement therapy. Maturitas 1992; 15: 113-19.
17. Holland EFN, Studd JWW, Mansell JP, Leather AT, Bailey AJ. Changes in collagen composition and cross-links in bone and skin of osteoporotic postmenopausal women treated with percutaneous estradiol implants. Obstet Gynecol 1994; 83: 180-3.
18. Bolognia JL, Braverman IM, Rousseau ME, Sarrel PM. Skin changes in menopause. Maturitas 1989; 11: 295-304.
19. Punnonen R, Vaajalahti P, Teisala K. Local oestriol treatment improves the structure of elastic fibers in the skin of postmenopausal women. Ann Chir Gynaecol 1987; 76(S202): 39-41.
20. Haapasaari K-M, Raudaskoski T, Kallioinen M, Suvanto-Luukkonen E, Kauppila A, Läärä E et al. Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women. Maturitas 1997; 27: 153-62.
21. Jemec GBE, Serup J. Short-term effects of topical 17β-oestradiol on human post-menopausal skin. Maturitas 1989; 11: 229-34.
22. Schmidt JB, Binder M, Macheiner W, Kainz C, Gitsch G, Bieglmayer C. Treatment of skin ageing symptoms in perimenopausal females with estrogen compounds. A pilot study. Maturitas 1994; 20: 25-30.
23. Schmidt JB, Binder M, Demschik G, Bieglmayer C, Reiner A. Treatment of skin aging with topical estrogens. Int J Dermatol 1996; 35: 669-74.
24. Varila E, Rantala I, Oikarinen A, Risteli J, Reunala T, Oksanen H et al. The effect of topical oestradiol on skin collagen of postmenopausal women. Br J Obstet Gynaecol 1995; 102: 985-9.
25. Oikarinen A, Peltonen J, Kallioinen M. Ultraviolet radiation in skin aging and carcinogenesis: the role of retinoids for treatment and prevention. Ann Med 1991; 23: 497-505.