The effect of oral folic acid upon plasma homocysteine, endothelial function and oxidative stress in patients with type 1 diabetes and microalbuminuria

International Journal of Clinical Practice

Volumn 62, Issue 4, 2008, Pages 569-574

  Wotherspoon, F ^a,d   Laight, D W ^b   Turner, C ^c   Meeking, D R ^a   Allard, S E ^a   Munday, L J ^a   Shaw, K M ^a   Cummings, M H ^a  

^a QUEEN ALEXANDRA HOSPITAL   (United Kingdom)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^c ST THOMAS HOSPITAL   (United Kingdom)

^d DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; GLUTATHIONE; HOMOCYSTEINE; PLACEBO;

ADULT; AMINO ACID BLOOD LEVEL; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; DRUG EFFECT; ENDOTHELIUM; FEMALE; FOREARM BLOOD FLOW; HIGH RISK POPULATION; HUMAN; HYPOTHESIS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MICROALBUMINURIA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SUPPLEMENTATION;

ADMINISTRATION, ORAL; ADULT; ALBUMINURIA; BLOOD FLOW VELOCITY; DIABETES MELLITUS, TYPE 1; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; FEMALE; FOLIC ACID; FOREARM; HOMOCYSTEINE; HUMANS; MALE; OMEGA-N-METHYLARGININE; OXIDATIVE STRESS;

EID: 40449102805     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2007.01658.x     Document Type: Article

References (34)

1. Stephenson JKS, Stevens L, Fuller J, Lee E. Proteinuria and mortality in diabetes: the WHO multinational study of vascular disease in diabetes. Diabet Med 1995 12 : 149 55.
2. Deckert TPJ, Larsen M. Prognosis of diabetics with diabetes onset before the age of thirty-one. Survival, causes of death and complications. Diabetologia 1978 14 : 363 77.
3. Behrendt DGP. Endothelial function. From vascular biology to clinical applications. Am J Clin Cardiol 2002 10 (Suppl. 3 L40 8.
4. Stehouwer CLJ, Donker A, Van Hinsbergh V. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res 1997 34 : 55 68.
5. Elliott T, Cockcroft J, Groop P-H, Viberti G, Ritter J. Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependant diabetic patients: blunted vasoconstriction in patients with microalbuminuria. Clin Sci 1993 85 : 687 93.
6. Dogra G, Rich L, Stanton K, Watts G. Endothelium-dependant and independent vasodilation studied at normoglycaemia in type 1 diabetes mellitus with and without microalbuminuria. Diabetologia 2001 44 : 593 601.
7. Johnstone M, Creager S, Scales K, Cusco J, Lee B, Creager M. Impaired endothelium-dependant vasodilation in patients with insulin-dependant diabetes mellitus. Circulation 1993 88 : 2510 26.
8. Wilcken DEL. Novel risk factors for vascular disease: the homocysteine hypothesis of cardiovascular disease. J Cardiovasc Risk 1998 5 : 217 21.
9. Welch GLJ. Homocysteine and atherothrombosis. NEJM 1998 338 : 1042 50.
10. Bellamy MF, McDowell IFW, Ramsey MW, Brownlee M, Newcombe RG, Lewis MJ. Oral folate enhances endothelial function in hyperhomocysteinuric subjects. Eur J Clin Invest 1999 29 : 659 62.
11. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest 1996 98 : 5 7.
12. Heinecke JRH, Suzuki L, Chait A. The role of sulphur-containing amino acids in superoxide production and modification of low-density lipoprotein by arterial smooth muscle cells. J Biol Chem 1987 262 : 100098 103.
13. Jones BRF, Tudball N. Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis 1994 105 : 165 70.
14. Upchurch GWG, Fabian A, Freedman J, Johnson J, Keaney J et al. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem 1997 272 : 17012 7.
15. Vaccaro O, Perna AF, Mancini FP et al. Plasma homocysteine and microvascular complications in type 1 diabetes. Nutr Metab Cardiovasc Dis 2000 10 : 297 304.
16. Chico A, Perez A, Cordoba A et al. Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: a new link between diabetic nephropathy and cardiovascular disease? Diabetologia 1998 41 : 684 93.
17. Hultberg B, Agardh E, Andersson A et al. Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus. Scand J Clin Lab Invest 1991 51 : 277 82.
18. Hofmann MA, Kohl B, Zumbach MS et al. Hyperhomocyst(e)inemia and endothelial dysfunction in IDDM. Diabetes Care 1998 21 : 841 8.
19. HLT Collaboration. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 1998 316 : 894 8.
20. Woo K, Chook P, Lolin Y, Sanderson J, Metreweli C, Celermajer D. Folic acid improves arterial endothelial function in adults with hyperhomocysteinemia. J Am Coll Cardiol 1999 34 : 2002 6.
21. Holven K, Holm T, Aukrust P et al. Effect of folic acid treatment on endothelium-dependant vasodilation and nitric oxide-derived end products in hyperhomocysteinemic subjects. Am Med J 2001 110 : 536 42.
22. Thambyrajah J, Landray MJ, Jones HJ, McGlynn FJ, Wheeler DC, Townend JN. A randomised double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. J Am Coll Cardiol 2001 37 : 1858 63.
23. Verhaar MCWR, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolaemia. Circulation 1998 97 : 237 41.
24. Doshi S, McDowell IFW, Moat S et al. Folate improves endothelial function in coronary artery disease, an effect mediated by reduction of intracellular superoxide? Arterioscler Thromb Vasc Biol 2001 21 : 1196 202.
25. Meeking D, Browne D, Allard S et al. Effects of cyclo-oxygenase inhibition on vasodilatory response to acetylcholine in patients with type 1 diabetes and nondiabetic subjects. Diabetes Care 2000 23 : 1 4.
26. Powrie JK, Watts GF, Ingham JN, Taub NA, Talmud PJ, Shaw KM. Role of glycaemic control in development of microalbuminuria in patients with insulin dependent diabetes. BMJ 1994 309 : 1608 12.
27. Hokanson D, Sumner D, Strandness D. An electronically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng 1975 121 : 1 27.
28. Calver A, Collier J, Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest 1992 90 : 2548 54.
29. Wilson J, Kapoor S. Contribution of prostaglandins to exercise-induced vasodilation in humans. Am J Physiol 1993 265 (1 Pt 2) : 171 3.
30. Laight D, Gunnarsson P, Kaw A, Anggard E, Carrier M. Physiological microassay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following experimental oxidant stress in vivo. Experimental Toxicology and Pharmacology 1999 7 : 27 31.
31. Tietze F. Enzymic method for quantitative determination of nanaogram amounts of total and oxidized glutathione. Analytical Biochemistry 1968 27 : 502 22.
32. Walker H, Jackson G, Ritter J, Chowienczyk P. Assessment of forearm vasodilator responses to acetylcholine and albuterol by strain gauge plethysmography: reproducibility and influence of strain gauge placement. Br J Clin Pharmacol 2001 51 : 225 9.
33. Malik RSI, Izzard A, Austin C, Bermann G, Heagerty A. Effects of angiotensin type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus. Hypertension 2005 45 : 264 9.
34. Munzel TKJ. Are ACE Inhibitors a "Magic Bullet" against oxidative stress? Circulation 2001 104 : 1571 4.