Protection against Shiga toxin-producing Escherichia coli infection by transcutaneous immunization with Shiga toxin subunit B

Clinical and Vaccine Immunology

Volumn 15, Issue 2, 2008, Pages 359-366

  Zhu, C ^a,b   Yu, J ^c   Yang, Z ^a,c   Davis, K ^a   Rios, H ^a   Wang, B ^b   Glenn, G ^c   Boedeker, E C ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c IOMAI Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI ENTEROTOXIN; IMMUNOGLOBULIN G ANTIBODY; SHIGA TOXIN 1B; VEROTOXIN 1; ANTITOXIN; BACTERIAL TOXIN; BACTERIUM ANTIBODY; ENTEROTOXIN; ENTEROTOXIN LT; ESCHERICHIA COLI PROTEIN; IMMUNOLOGICAL ADJUVANT; PROTEIN SUBUNIT; SHIGA TOXIN; SUBUNIT VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; ENTEROBACTER INFECTION; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOLYTIC UREMIC SYNDROME; HEMORRHAGIC COLITIS; HISTOPATHOLOGY; IMMUNIZATION; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; RABBIT; SERODIAGNOSIS; TOXIN NEUTRALIZATION TEST; WEIGHT GAIN; ANIMAL; BILE; BLOOD; BODY WEIGHT; CECUM; COLITIS; FECES; IMMUNOLOGY; INTESTINE MUCOSA; INTRADERMAL DRUG ADMINISTRATION; KIDNEY; MICROBIOLOGY; PATHOLOGY; SERUM; SHIGA TOXIN PRODUCING ESCHERICHIA COLI;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIBODIES, BACTERIAL; ANTITOXINS; BACTERIAL TOXINS; BILE; BODY WEIGHT; CECUM; COLITIS; ENTEROTOXINS; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; FECES; HEMOLYTIC-UREMIC SYNDROME; INTESTINAL MUCOSA; KIDNEY; PROTEIN SUBUNITS; RABBITS; SERUM; SHIGA TOXIN; SHIGA-TOXIGENIC ESCHERICHIA COLI; VACCINES, SUBUNIT;

EID: 40449093641     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00399-07     Document Type: Article

References (42)

1. Acheson, D. W., S. B. Calderwood, S. A. Boyko, L. L. Lincicome, A. V. Kane, A. Donohue-Rolfe, and G. T. Keusch. 1993. Comparison of Shiga-like toxin I B-subunit expression and localization in Escherichia coli and Vibrio cholerae by using trc or iron-regulated promoter systems. Infect. Immun. 61:1098-2104.
2. Agin, T. S., C. Zhu, L. A. Jonson, T. E. Thate, Z. Yang, and E. C. Boedeker. 2005. Protection against hemorrhagic colitis in an animal model by oral immunization with isogenic rabbit enteropathogenic Escherichia coli attenuated by truncating intimin. Infect. Immun. 73:6608-6619.
3. Bielaszewska, M., I. Clarke, M. A. Karmali, and M. Petric. 1997. Localization of intravenously administered verocytotoxins (Shiga-like toxins) 1 and 2 in rabbits immunized with homologous and heterologous toxoids and toxin subunits. Infect. Immun. 65:2509-2516.
4. Boedeker, E. C., C. Zhu, H. Rios, and K. Davis. 2006 Rabbit enteropathogenic strains expressing Shiga toxin 1 (Stx1) or 2 (Stx2) induce intestinal and renal lesions of hemolytic uremic syndrome (HUS) in Dutch Belted rabbits, abstract P10.2.10. Abstr. 6th Int. Symp. Shiga Toxin (Verotoxin)-Producing E. coli Infect., Melbourne, Australia.
5. Boyd, B., and C. Lingwood. 1989. Verotoxin receptor glycolipid in human renal tissue. Nephron 51:207-210.
6. Garcia, A., and J. G. Fox. 2003. The rabbit as a new reservoir host of enterohemorrhagic Escherichia coli. Emerg. Infect. Dis. 9:1592-1597.
7. Garcia, A., C. J. Bosques, J. S. Wishnok, Y. Feng, B. J. Karalius, J. R. Butterton, D. B. Schauer, A. B. Rogers, and J. G. Fox. 2006. Renal injury is a consistent finding in Dutch Belted rabbits experimentally infected with enterohemorrhagic Escherichia coli. J. Infect. Dis. 193:1125-1134.
8. Glenn, G. M., T. Scharton-Kersten, R. Vassell, C. P. Mallett, T. L. Hale, and C. R. Alving. 1998. Transcutaneous immunization with cholera toxin protects mice against lethal mucosal toxin challenge. J. Immunol. 161:3211-3214.
9. Glenn, G. M., M. Rao, G. R. Matyas, and C. R. Alving. 1998. Skin immunization made possible by cholera toxin. Nature 391:851.
10. Glenn, G. M., T. Scharton-Kersten, R. Vassell, G. R. Matyas, and C. R. Alving. 1999. Transcutaneous immunization with bacterial ADP-ribosylating exotoxins as antigens and adjuvants. Infect. Immun. 67:1100-1106.
11. Glenn, G. M., R. T. Kenney, S. A. Hammond, and L. R. Ellingsworth. 2003. Transcutaneous immunization and immunostimulant strategies. Immunol. Allergy Clin. North Am. 23:787-813.
12. Grif, K., M. P. Dierich, H. Karch, and F. Allerberger. 1998. Strain-specific differences in the amount of Shiga toxin released from enterohemorrhagic Escherichia coli O157 following exposure to subinhibitory concentrations of antimicrobial agents. Eur. J. Clin. Microbiol. Infect. Dis. 17:761-766.
13. Griffin, P. M., and R. V. Tauxe. 1991. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic uremic syndrome. Epidemiol. Rev. 13:60-98.
14. Hoffman, M., A. C. Menge, T. A. Casey, W. Laegreid, and B. T. Bosworth, and E. A. Dean-Nystrom. 2006. Bovine immune response to Shiga-toxigenic Escherichia coli O157:H7. Clin. Vaccine Immunol. 13:1322-1327.
15. Hovde, C. J., S. B. Calderwood, J. J. Mekalanos, and R. J. Collier. 1988. Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. Proc. Natl. Acad. Sci. USA 85:2568-2572.
16. Jackson, M. P., J. W. Newland, R. K. Holmes, and A. D. O'Brien. 1987. Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli. Microb. Pathog. 2:147-153.
17. Jackson, M. P., R. L. Deresiewicz, and S. B. Calderwood. 1990. Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits. J. Bacteriol. 172:3346-3350.
18. Jackson, M. P. 1990. Structure-function analyses of Shiga toxin and the Shiga-like toxins. Microb. Pathog. 8:235-242.
19. Kaper, J. B., J. P. Nataro, and H. L. Mobley. 2004. Pathogenic Escherichia coli. Nat. Rev. Microbiol. 2:123-140.
20. Karmali, M. A. 2004. Infection by Shiga toxin-producing Escherichia coli: an overview. Mol. Biotechnol. 26:117-122.
21. Karmali, M. A., B. T. Steele, M. Petric, and C. Lim. 1983. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cytotoxin and cytotoxin-producing Escherichia coli in stools. Lancet i:619-620.
22. Kenney, R. T., J. Yu, M. Guebre-Xabier, S. A. Frech, A. Lambert, B. A. Heller, L. R. Ellingsworth, J. E. Eyles, E. D. Williamson, and G. M. Glenn. 2004. Induction of protective immunity against lethal anthrax challenge with a patch. J. Infect. Dis. 190:774-782.
23. Kohler, B., H. Karch, and H. Schmidt. 2000. Antibacterials that are used as growth promoters in animal husbandry can affect the release of Shiga-toxin-2-converting bacteriophages and Shiga toxin 2 from Escherichia coli strains. Microbiology 146:1085-1090.
24. Loser, K., A. Mehling, S. Loeser, J. Apelt, A. Kuhn, S. Grabbe, et al. 2006. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat. Med. 12:1372-1379.
25. Mead, P. S., L. Slutsker, V. Dietz, L. F. McCaig, J. S. Bresee, C. Shapiro, P. M. Griffin, and R. V. Tauxe. 1999. Food-related illness and death in the United States. Emerg. Infect. Dis. 5:607-625.
26. Nataro, J. P., and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142-201.
27. Noel, J. M., and E. C. Boedeker. 1997. Enterohemorrhagic Escherichia coli: a family of emerging pathogens. Dig. Dis. 15:67-91.
28. O'Brien, A. D., V. L. Tesh, A. Donohue-Rolfe, M. P. Jackson, S. Olsnes, K. Sandvig, A. A. Lindberg, and G. T. Keusch. 1992. Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis. Curr. Top. Microbiol. Immunol. 180:65-94.
29. Obrig, T. G., C. B. Louise, C. A. Lingwood, B. Boyd, L. Barley-Maloney, and T. O. Daniel. 1993. Endothelial heterogeneity in Shiga toxin receptors and responses. J. Biol. Chem. 268:15484-15488.
30. Oosterwijk, E., A. Kalisiak, J. C. Wakka, D. A. Scheinberg, and L. J. Old. 1991. Monoclonal antibodies against Gal alpha 1-4Gal beta 1-4Glc (Pk, CD77) produced with a synthetic glycoconjugate as immunogen: reactivity with carbohydrates, with fresh frozen human tissues and hematopoietic tumors. Int. J. Cancer 48:848-854.
31. Randolph, G. J., V. Angeli, and M. A. Swartz. 2005. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 5:617-628.
32. Robinson, C. M., J. F. Sinclair, M. J. Smith, and A. D. O'Brien. 2006. Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization. Proc. Natl. Acad. Sci. USA 103:9667-9672.
33. Sinclair, J. F., and A. D. O'Brien. 2001. Cell-surface localized nucleolin is a eucaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157: H7. J. Biol. Chem. 277:76-85.
34. Sjogren, R., R. Neill, D. Rachmilewitz, D. Fritz, J. Newland, D. Sharpnack, C. Colleton, J. Fondacaro, P. Gemski, and E. C. Boedeker. 1994. Role of Shiga-like toxin I in bacterial enteritis: comparison between isogenic Escherichia coli strains induced in rabbits. Gastroenterology 106:306-317.
35. Smith, M. J., L. D. Teel, H. M. Carvalho, A. R. Melton-Celsa, and A. D. O'Brien. 2006. Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2. Vaccine 24:4122-4129.
36. Su, G. F., H. N. Brahmbhatt, J. Wehland, M. Rohde, and K. N. Timmis. 1992. Construction of stable LamB-Shiga toxin B subunit hybrids: analysis of expression in Salmonella typhimurium aroA strains and stimulation of B subunit-specific mucosal and serum antibody responses. Infect. Immun. 60: 3345-3359.
37. Tesh, V. L., and A. D. O'Brien. 1991. The pathogenic mechanisms of Shiga toxin and the Shiga-like toxins. Mol. Microbiol. 5:1817-1822.
38. Yu, J., F. Cassels, T. Scharton-Kersten, S. A. Hammond, A. Hartman, E. Angov, B. Corthésy, C. Alving, and G. M. Glenn. 2002. Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli. Infect. Immun. 70:1056-1068.
39. Zhang, X., A. D. McDaniel, L. E. Wolf, G. T. Keusch, M. K. Waldor, and D. W. Acheson. 2000. Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice. J. Infect. Dis. 181:664-670.
40. Zhu, C., T. S. Agin, S. J. Elliott, L. A. Johnson, T. E. Thate, J. B. Kaper, and E. C. Boedeker. 2001. Complete nucleotide sequence and analysis of the locus of enterocyte effacement from rabbit diarrheagenic Escherichia coli RDEC-1. Infect. Immun. 69:2107-2115.
41. Zhu, C., S. Feng, T. E. Thate, J. B. Kaper, and E. C. Boedeker. 2006. Towards a vaccine for attaching/effacing Escherichia coli: a LEE encoded regulator (ler) mutant of rabbit enteropathogenic Escherichia coli is attenuated, immunogenic, and protects rabbits from lethal challenge with the wild-type virulent strain. Vaccine 24:3845-3855.
42. Zhu, C., F. Ruiz-Perez, Z. Yang, Y. Mao, V. L. Hackethal, K. M. Greco, W. Choy, K. Davis, J. R. Butterton, and E. C. Boedeker. 2006. Delivery of heterologous protein antigens via hemolysin or autotransporter systems by an attenuated ler mutant of rabbit enteropathogenic Escherichia coli. Vaccine 24:3821-3831.