Chemotherapy-induced pica and anorexia are reduced by common hepatic branch vagotomy in the rat

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 294, Issue 3, 2008, Pages

  De Jonghe, Bart C ^a   Horn, Charles C ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Cisplatin; Emesis; Nausea; Vagus

Indexed keywords

ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; APOMORPHINE; CISPLATIN; DOPAMINE RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CANCER CHEMOTHERAPY; CELIAC PLEXUS; CHEMOTHERAPY INDUCED EMESIS; CONTROLLED STUDY; DUODENUM; ELECTROPHYSIOLOGY; FOOD INTAKE; MALAISE; MALE; NAUSEA; NONHUMAN; PICA; PRIORITY JOURNAL; RAT; SENSORY NERVE; STOMACH INNERVATION; VAGOTOMY; VAGUS NERVE;

ANIMALS; ANOREXIA; ANTINEOPLASTIC AGENTS; APOMORPHINE; BODY WEIGHT; CELIAC PLEXUS; CISPLATIN; DOPAMINE AGONISTS; DRINKING; EATING; KAOLIN; LIVER; MALE; PICA; RATS; RATS, SPRAGUE-DAWLEY; STOMACH; VAGOTOMY; VOMITING;

EID: 40449088588     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00820.2007     Document Type: Article

References (64)

1. Andrews PL, Davis CJ, Bingham S, Davidson HI, Hawthorn J, Maskell L. The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Can J Physiol Pharmacol 68: 325-345, 1990.
2. Andrews PL, Horn CC. Signals for nausea and emesis: implications for models of upper gastrointestinal diseases. Auton Neurosci 125: 100-115, 2006.
3. Andrews PL, Kovacs M, Watson JW. The anti-emetic action of the neurokinin1 receptor antagonist CP-99,994 does not require the presence of the area postrema in the dog. Neurosci Lett 314: 102-104, 2001.
4. Andrews PLR, Rudd JA. The role of tachykinins and the tachykinin NK1 receptor in nausea and emesis. In: Tachykinins: Handbook of Experimental Pharmacology, edited by Holzer P. New York: Springer, 2004, p. 359-441.
5. Bearcroft CP, Domizio P, Mourad FH, Andre EA, Farthing MJ. Cisplatin impairs fluid and electrolyte absorption in rat small intestine: a role for 5-hydroxytryptamine. Gut 44: 174-179, 1999.
6. Berthoud HR, Carlson NR, Powley TL. Topography of efferent vagal innervation of the rat gastrointestinal tract. Am J Physiol Regul Integr Comp Physiol 260: R200-R207, 1991.
7. Berthoud HR, Patterson LM, Willing AE, Mueller K, Neuhuber WL. Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: anatomical identification and functional integrity. Brain Res 746: 195-206, 1997.
8. Blachley JD, Hill JB. Renal and electrolyte disturbances associated with cisplatin. Ann Intern Med 95: 628-632, 1981.
9. Cubeddu LX, Hoffmann IS, Fuenmayor NT, Malave JJ. Changes in serotonin metabolism in cancer patients: its relationship to nausea and vomiting induced by chemotherapeutic drugs. Br J Cancer 66: 198-203, 1992.
10. Endo T, Takahashi M, Minami M, Yoshioka M, Saito H, Parvez HS. Changes in the afferent abdominal vagal nerve activity induced by cisplatin and copper sulfate in the ferret. Biogenic Amines 11: 399-407, 1995.
11. Fukui H, Yamamoto M, Ando T, Sasaki S, Sato S. Increase in serotonin levels in the dog ileum and blood by cisplatin as measured by microdialysis. Neuropharmacology 32: 959-968, 1993.
12. 3 receptors and vagal afferents in copper sulfate- and cisplatin-induced emesis in monkeys. Eur J Pharmacol 249: 13-18, 1993.
13. 3 receptors mediate cisplatin-induced emesis in dogs. Jpn J Pharmacol 59: 221-226, 1992.
14. Garcia-Medina NE, Jimenez-Capdeville ME, Ciucci M, Martinez LM, Delgado JM, Horn CC. Conditioned flavor aversion and brain Fos expression following exposure to arsenic. Toxicology 235: 73-82, 2007.
15. Gordon JA, Peterson LN, Anderson RJ. Water metabolism after cisplatin in the rat. Am J Physiol Renal Fluid Electrolyte Physiol 243: F36-F43, 1982.
16. Harding RK, Hugenholtz H, Kucharczyk J, Lemoine J. Central mechanisms for apomorphine-induced emesis in the dog. Eur J Pharmacol 144: 61-65, 1987.
17. Hawthorn J, Ostler KJ, Andrews PL. The role of the abdominal visceral innervation and 5-hydroxytryptamine M-receptors in vomiting induced by the cytotoxic drugs cyclophosphamide and cis-platin in the ferret. Q J Exp Physiol 73: 7-21, 1988.
18. Higa GM, Auber ML, Altaha R, Piktel D, Kurian S, Hobbs G, Landreth K. 5-Hydroxyindoleacetic acid and substance P profiles in patients receiving emetogenic chemotherapy. J Oncol Pharm Pract 12: 201-209, 2006.
19. Hillsley K, Grundy D. Plasticity in the mesenteric afferent response to cisplatin following vagotomy in the rat. J Auton Nerv Syst 76: 93-98, 1999.
20. Horn CC. Is there a need to identify new anti-emetic drugs? Drug Discov Today: Therapeut Strateg First published November 5, 2007; doi: 10.1016/j.ddstr.2007.09.002.
21. Horn CC. Why is the neurobiology of nausea and vomiting so important? Appetite (October 11, 2007). doi: 10.1016/j.appet.2007.09.015.
22. Horn CC, Ciucci M, Chaudhury A. Brain Fos expression during 48 h after cisplatin treatment: neural pathways for acute and delayed visceral sickness. Auton Neurosci 132: 44-51, 2007.
23. Horn CC, Friedman MI. Detection of single unit activity from the rat vagus using cluster analysis of principal components. J Neurosci Methods 122: 141-147, 2003.
24. Horn CC, Friedman MI. Separation of hepatic and gastrointestinal signals from the common "hepatic" branch of the vagus. Am J Physiol Regul Integr Comp Physiol 287: R120-R126, 2004.
25. Horn CC, Friedman MI. Thoracic cross-over pathways of the rat vagal trunks. Brain Res 1060: 153-161, 2005.
26. Horn CC, Mitchell JC. Does selective vagotomy affect conditioned flavor-nutrient preferences in rats? Physiol Behav 59: 33-38, 1996.
27. Horn CC, Richardson EJ, Andrews PL, Friedman MI. Differential effects on gastrointestinal and hepatic vagal afferent fibers in the rat by the anti-cancer agent cisplatin. Auton Neurosci 115: 74-81, 2004.
28. Jordan K. Neurokinin-1-receptor antagonists: a new approach in antiemetic therapy. Onkologie 29: 39-43, 2006.
29. Kayashima N, Iwasaki M, Hayama T. Site of emetic action of oral copper sulfate in dogs. II. Importance of lower duodenum. Jpn J Pharmacol 28: 797-801, 1978.
30. Kayashima N, Tanaka M, Iwasaki M, Hayama T. Site of emetic action of oral copper sulfate in dogs. I. Thresholds of various portions of gastrointestinal tract to locally applied copper sulfate. Jpn J Pharmacol 28: 775-781, 1978.
31. Knox AP, Strominger NL, Battles AH, Carpenter DO. Behavioral studies of emetic sensitivity in the ferret. Brain Res Bull 31: 477-484, 1993.
32. Kraly FS, Jerome C, Smith GP. Specific postoperative syndromes after total and selective vagotomies in the rat. Appetite 7: 1-17, 1986.
33. Kris MG, Hesketh PJ, Somerfield MR, Feyer P, Clark-Snow R, Koeller JM, Morrow GR, Chinnery LW, Chesney MJ, Gralla RJ, Grunberg SM. American Society of Clinical Oncology guideline for antiemetics in oncology: update 2006. J Clin Oncol 24: 2932-2947, 2006.
34. Lang IM. Digestive tract motor correlates of vomiting and nausea. Can J Physiol Pharmacol 68: 242-253, 1990.
35. Li Y, Owyang C. Musings on the wanderer: what's new in our understanding of vago-vagal reflexes? V. Remodeling of vagus and enteric neural circuitry after vagal injury. Am J Physiol Gastrointest Liver Physiol 285: G461-G469, 2003.
36. Malik NM, Liu YL, Cole N, Sanger GJ, Andrews PL. Differential effects of dexamethasone, ondansetron and a tachykinin NK1 receptor antagonist (GR205171) on cisplatin-induced changes in behaviour, food intake, pica and gastric function in rats. Eur J Pharmacol 555: 164-173, 2007.
37. Malik NM, Moore GB, Smith G, Liu YL, Sanger GJ, Andrews PL. Behavioural and hypothalamic molecular effects of the anti-cancer agent cisplatin in the rat: a model of chemotherapy-related malaise? Pharmacol Biochem Behav 83: 9-20, 2006.
38. Matsumoto S, Kawasaki Y, Mikami M, Nakamoto M, Tokuyasu H, Kometani Y, Chikumi H, Hitsuda Y, Matsumoto Y, Sasaki T. [Relationship between cancer chemotherapeutic drug-induced delayed emesis and plasma levels of substance P in two patients with small cell lung cancer]. Gan To Kagaku Ryoho 26: 535-538, 1999.
39. Minami M, Endo T, Hirafuji M, Hamaue N, Liu Y, Hiroshige T, Nemoto M, Saito H, Yoshioka M. Pharmacological aspects of anticancer drug-induced emesis with emphasis on serotonin release and vagal nerve activity. Pharmacol Ther 99: 149-165, 2003.
40. Neary NM, Small CJ, Wren AM, Lee JL, Druce MR, Palmieri C, Frost GS, Ghatei MA, Coombes RC, Bloom SR. Ghrelin increases energy intake in cancer patients with impaired appetite: acute, randomized, placebo-controlled trial. J Clin Endocrinol Metab 89: 2832-2836, 2004.
41. Osei-Hyiaman D. Endocannabinoid system in cancer cachexia. Curr Opin Clin Nutr Metab Care 10: 443-448, 2007.
42. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. New York: Academic, 2005.
43. Phillips RJ, Baronowsky EA, Powley TL. Afferent innervation of gastrointestinal tract smooth muscle by the hepatic branch of the vagus. J Comp Neurol 384: 248-270, 1997.
44. Phillips RJ, Powley TL. Gastric volume detection after selective vagotomies in rats. Am J Physiol Regul Integr Comp Physiol 274: R1626-R1638, 1998.
45. Powley TL, Fox EA, Berthoud HR. Retrograde tracer technique for assessment of selective and total subdiaphragmatic vagotomies. Am J Physiol Regul Integr Comp Physiol 253: R361-R370, 1987.
46. Prechtl JC, Powley TL. Organization and distribution of the rat subdiaphragmatic vagus and associated paraganglia. J Comp Neurol 235: 182-195, 1985.
47. Prechtl JC, Powley TL. A light and electron microscopic examination of the vagal hepatic branch of the rat. Anat Embryol (Berl) 176: 115-126, 1987.
48. Prechtl JC, Powley TL. The fiber composition of the abdominal vagus of the rat. Anat Embryol (Berl) 181: 101-115, 1990.
49. Raybould HE, Tache Y. Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. Am J Physiol Gastrointest Liver Physiol 255: G242-G246, 1988.
50. Rudd JA, Andrews PLR. Mechanisms of acute, delayed, and anticipatory emesis induced by anticancer therapies. In: Management of Nausea and Vomiting in Cancer and Cancer Treatment, edited by Hesketh PJ. Sudbury, MA: Jones and Bartlett, 2005, p. 15-65.
51. Rudd JA, Ngan MP, Wai MK, King AG, Witherington J, Andrews PL, Sanger GJ. Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin. Neurosci Lett 392: 79-83, 2006.
52. Rudd JA, Yamamoto K, Yamatodani A, Takeda N. Differential action of ondansetron and dexamethasone to modify cisplatin-induced acute and delayed kaolin consumption ("pica") in rats. Eur J Pharmacol 454: 47-52, 2002.
53. Saeki M, Sakai M, Saito R, Kubota H, Ariumi H, Takano Y, Yamatodani A, Kamiya H. Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats. Jpn J Pharmacol 86: 359-362, 2001.
54. Saito R, Takano Y. [Easy method for emesis using rats]. Nippon Yakurigaku Zasshi 127: 461-466, 2006.
55. 3 receptor antagonists and dexamethasone to modify cisplatin-induced emesis in Suncus murinus (house musk shrew). Eur J Pharmacol 472: 135-145, 2003.
56. Sharkey KA, Cristino L, Oland LD, Van S, Starowicz K, Pittman QJ, Guglielmotti V, Davison JS, Di Marzo V. Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret. Eur J Neurosci 25: 2773-2782, 2007.
57. Smith GP, Jerome C, Norgren R. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol Regul Integr Comp Physiol 249: R638-R641, 1985.
58. Takeda N, Hasegawa S, Morita M, Matsunaga T. Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol Biochem Behav 45: 817-821, 1993.
59. Tordoff MG, Hopfenbeck J, Novin D. Hepatic vagotomy (partial hepatic denervation) does not alter ingestive responses to metabolic changes. Physiol Behav 28: 417-424, 1982.
60. Uno A, Takeda N, Horii A, Sakata Y, Yamatodani A, Kubo T. Effects of amygdala or hippocampus lesion on hypergravity-induced motion sickness in rats. Acta Otolaryngol 120: 860-865, 2000.
61. Vera G, Chiarlone A, Martin MI, Abalo R. Altered feeding behaviour induced by long-term cisplatin in rats. Auton Neurosci 126-127: 81-92, 2006.
62. Wang CZ, Basila D, Aung HH, Mehendale SR, Chang WT, McEntee E, Guan X, Yuan CS. Effects of ganoderma lucidum extract on chemotherapy-induced nausea and vomiting in a rat model. Am J Chin Med 33: 807-815, 2005.
63. Wang FB, Powley TL. Vagal innervation of intestines: afferent pathways mapped with new en bloc horseradish peroxidase adaptation. Cell Tissue Res 329: 221-230, 2007.
64. Wood LJ, Nail LM, Gilster A, Winters KA, Elsea CR. Cancer chemotherapy-related symptoms: evidence to suggest a role for proinflammatory cytokines. Oncol Nurs Forum 33: 535-542, 2006.