Cloning and genetic analyses of the bacteriocin 41 determinant encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pYI14: A novel bacteriocin complemented by two extracellular components (lysin and activator)

Journal of Bacteriology

Volumn 190, Issue 6, 2008, Pages 2075-2085

  Tomita, Haruyoshi ^a   Kamei, Elizabeth ^a   Ike, Yasuyoshi ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOCIN; CELL SURFACE RECEPTOR; HYDROLASE; LYSINE; PHEROMONE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL IMMUNITY; BACTERIAL STRAIN; CULTURE MEDIUM; ENTEROCOCCUS FAECALIS; ENZYME ACTIVITY; ENZYME STRUCTURE; EXTRACELLULAR SPACE; GENETIC ANALYSIS; GRAM POSITIVE BACTERIUM; HOST; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PLASMID; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BACTERIOCINS; CLONING, MOLECULAR; DNA RESTRICTION ENZYMES; DNA TRANSPOSABLE ELEMENTS; ENTEROCOCCUS FAECALIS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; MUCOPROTEINS; MUTAGENESIS, INSERTIONAL; OPEN READING FRAMES; PHEROMONES; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS FAECALIS; POSIBACTERIA;

EID: 40449084234     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01056-07     Document Type: Article

References (51)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Booth, M. C., C. P. Bogie, H.-G. Sahl, R. J. Siezen, K. L. Hatter, and M. S. Gilmore. 1996. Structural analysis and proteolytic activation of Enterococcus faecalis cytolysin, a novel lantibiotic. Mol. Microbiol. 21:1175-1184.
3. Brock, T. D., B. Peacher, and D. Pierson. 1963. Survey of the bacteriocins of enterococci. J. Bacteriol. 86:702-707.
4. Chow, J. W., L. A. Thal, M. B. Perri, J. A. Vazquez, S. M. Donabedian, D. B. Clewell, and M. J. Zervos. 1993. Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis. Antimicrob. Agents Chemother. 37:2474-2477.
5. Clewell, D. B. 1981. Plasmids, drug resistance, and gene transfer in the genus Streptococcus. Microbiol. Rev. 45:409-436.
6. Clewell, D. B., and G. M. Dunny. 2002. Conjugation and genetic exchange in enterococci, p. 265-300. In M. S. Gilmore, D. B. Clewell, P. Courvalin, G. M. Dunne, B. E. Murray, and L. B. Rice, (ed.), The enterococci: pathogenesis, molecular biology and antibiotic resistance. ASM Press, Washington, DC.
7. Clewell, D. B., P. K. Tomich, M. C. Gawron-Burke, A. E. Franke, Y. Yagi, and F. Y. An. 1982. Mapping of Streptococcus faecalis plasmids pAD1 and pAD2 and studies relating to transposition of Tn917. J. Bacteriol. 152:1220-1230.
8. Coburn, P. S., L. E. Hancock, M. C. Booth, and M. S. Gilmore. 1999. A novel means of self-protection, unrelated to toxin activation, confers immunity to the bactericidal effects of the Enterococcus faecalis cytolysin. Infect. Immun. 67:3339-3347.
9. Coburn, P. S., C. M. Pillar, B. D. Jett, W. Haas, and M. S. Gilmore. 2004. Enterococcus faecalis senses target cells and in response expresses cytolysin. Science 306:2270-2272.
10. Coque, T. M., J. E. Patterson, J. M. Steckelberg, and B. E. Murray. 1995. Incidence of hemolysin, gelatinase, and aggregation substance among enterococci isolated from patients with endocarditis and other infections and from feces of hospitalized and community-based persons. J. Infect. Dis. 171:1223-1229.
11. Dunny, G. M., B. L. Brown, and D. B. Clewell. 1978. Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone. Proc. Natl. Acad. Sci. USA 75:3479-3483.
12. Dunny, G. M., R. A. Craig, R. L. Carron, and D. B. Clewell. 1979. Plasmid transfer in Streptococcus faecalis: production of multiple sex pheromones by recipients. Plasmid 2:454-465.
13. Fujimoto, S., H. Hashimoto, and Y. Ike. 1991. Low cost device for electrotransformation and its application to the highly efficient transformation of Escherichia coli and Enterococcus faecalis. Plasmid 26:131-135.
14. Fujimoto, S., H. Tomita, E. Wakamatsu, K. Tanimoto, and Y. Ike. 1995. Physical mapping of the conjugative bacteriocin plasmid pPD1 of Enterococcus faecalis and identification of the determinant related to the pheromone response. J. Bacteriol. 177:5574-5581.
15. Franz, C. M. A. P., M. J. van Belkum, W. H. Holzapfel, H. Abriouel, and A. Galvez. 2007. Diversity of enterococcal bacteriocins and their grouping in a new classification scheme. FEMS Microbiol. Rev. 31:293-310.
16. Gilmore, M. S., R. A. Segarra, and M. C. Booth. 1990. An HlyB-type function is required for expression of the Enterococcus faecalis hemolysin/bacteriocin. Infect. Immun. 58:3914-3923.
17. Gilmore, M. S., R. A. Segarra, M. C. Booth, C. P. Bogie, L. R. Hall, and D. B. Clewell. 1994. Genetic structure of the Enterococcus faecalis plasmid pAD1-encoded cytolytic toxin system and its relationship to lantibiotic determinants. J. Bacteriol. 176:7335-7344.
18. Haas, W., B. D. Shepard, and M. S. Gilmore. 2002. Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction. Nature 415:84-87.
19. Hanski, E., P. A. Horvitz, and M. G. Caparon. 1992. Expression of protein F, the fibronectin-binding protein of Streptococcus pyogenes JRS4, in heterologous streptococcal and enterococcal strains promotes their adherence to respiratory epithelial cells. Infect. Immun. 60:5119-5125.
20. Ike, Y., and D. B. Clewell. 1984. Genetic analysis of the pAD1 pheromone response in Streptococcus faecalis, using transposon Tn917 as an insertional mutagen. J. Bacteriol. 158:777-783.
21. Ike, Y., and D. B. Clewell. 1992. Evidence that the hemolysin/bacteriocin phenotype of Enterococcus faecalis subsp. zymogenes can be determined by plasmids in different incompatibility groups as well as by the chromosome. J. Bacteriol. 174:8172-8177.
22. Ike, Y., D. B. Clewell, R. A. Segarra, and M. S. Gilmore. 1990. Genetic analysis of the pAD1 hemolysin/bacteriocin determinant in Enterococcus faecalis: Tn917 insertional mutagenesis and cloning. J. Bacteriol. 172:155-163.
23. Ike, Y., R. A. Craig, B. A. White, Y. Yagi, and D. B. Clewell. 1983. Modification of Streptococcus faecalis sex pheromones after acquisition of plasmid DNA. Proc. Natl. Acad. Sci. USA 80:5369-5373.
24. Ike, Y., S. E. Flannagan, and D. B. Clewell. 1992. Hyperhemolytic phenomena associated with insertions of Tn916 into the hemolysin determinant of Enterococcus faecalis plasmid pAD1. J. Bacteriol. 174:1801-1809.
25. Ike, Y., H. Hashimoto, and D. B. Clewell. 1984. Hemolysin of Streptococcus faecalis subspecies zymogenes contributes to virulence in mice. Infect. Immun. 45:528-530.
26. Ike, Y., H. Hashimoto, and D. B. Clewell. 1987. High incidence of hemolysin production by Enterococcus (Streptococcus) faecalis strains associated with human parenteral infection. J. Clin. Microbiol. 25:1524-1528.
27. Jack, R. W., J. R. Tagg, and B. Ray. 1995. Bacteriocins of gram-positive bacteria. Microbiol. Rev. 59:171-200.
28. Jedrzejas, M. K. 2001. Pneumococcal virulence factors: structure and function. Microbiol. Mol. Biol. Rev. 65:187-207.
29. Jett, B. D., H. G. Jensen, R. E. Nordquist, and M. S. Gilmore. 1992. Contribution of the pAD1-encoded cytolysin to the severity of experimental Enterococcus faecalis endophthalmitis. Infect. Immun. 60:2445-2452.
30. Kleerebezem, M., J. Boekhorst, R. van Kranenburg, D. Molenaar, O. P. Kuipers, R. Leer, R. Tarchini, S. A. Peters, H. M. Sandbrink, M. W. E. J. Fiers, W. Stiekema, R. M. Klein Lankhorst, P. A. Bron, S. M. Hoffer, M. N. Nierop Groot, R. Kerkhoven, M. de Vries, B. Ursing, W. M. de Vos, and R. J. Siezen. 2003. Complete genome sequence of Lactobacillus plantarum WCFS1. Proc. Natl. Acad. Sci. USA 100:1990-1995.
31. LeBlanc, D. J., L. N. Lee, D. B. Clewell, and D. Behnke. 1983. Broad geographical distribution of a cytotoxin gene mediating beta-hemolysis and bacteriocin activity among Streptococcus faecalis strains. Infect. Immun. 40: 1015-1022.
32. Lópes, R., and E. Garcia. 2004. Recent trends on the molecular biology of pneumococcal capsules, lytic enzymes, and bacteriophage. FEMS Microbiol. Rev. 28:553-580.
33. Martínez-Bueno, M., M. Maqueda, A. Galvez, B. Samyn, J. V. Beeumen, J. Coyette, and E. Valdivia. 1994. Determination of the gene sequence and the molecular structure of the enterococcus peptide antibiotic AS-48. J. Bacteriol. 176:6334-6339.
34. Navarre, W. W., and O. Schneewind. 1999. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol. Mol. Biol. Rev. 63:174-229.
35. Nes, I. F., D. B. Diep, and H. Holo. 2007. Bacteriocin diversity in Streptococcus and Enterococcus. J. Bacteriol. 189:1189-1198.
36. Nilsen, T., I. F. Nes, and H. Holo. 2003. Enterolysin A, a cell wall-degrading bacteriocin from Enterococcus faecalis LMG 2333. Appl. Environ. Microbiol. 69:2975-2984.
37. Pecenková, T., V. Benes, J. Paces, C. Vlcek, and V. Paces. 1997. Bacteriophage B103: complete DNA sequence of its genome and relationship to other Bacillus phages. Gene 199:157-163.
38. Sambrook, J., and D. W. Russell. 2001. Molecular cloning: a laboratory manual, 3rd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
39. Segarra, R. A., M. C. Booth, D. A. Morales, M. M. Huycke, and M. S. Gilmore. 1991. Molecular characterization of the Enterococcus faecalis cytolysin activator. Infect. Immun. 59:1239-1246.
40. Sheehan, M. M., J. L. García, R. López, and P. García. 1997. The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin. Mol. Microbiol. 25:717-725.
41. Shiojima, M., H. Tomita, K. Tanimoto, S. Fujimoto, and Y. Ike. 1997. High-level plasmid-mediated gentamicin resistance and pheromone response of plasmids present in clinical isolates of Enterococcus faecalis. Antimicrob. Agents Chemother. 41:702-705.
42. Tanimoto, K., and T. Iino. 1985. Additional genes essential for replication of the mini-F plasmid from origin I. Mol. Gen. Genet. 198:358-359.
43. Tettelin, H., V. Masignani, M. J. Cieslewicz, J. A. Eisen, S. Peterson, M. R. Wessels, I. T. Paulsen, K. E. Nelson, I. Margarit, T. D. Read, L. C. Madoff, A. M. Wolf, M. J. Beanan, L. M. Brinkac, S. C. Daugherty, R. T. DeBoy, A. S. Durkin, J. F. Kolonay, R. Madupu, M. R. Lewis, D. Radune, N. B. Fedorova, D. Scanlan, H. Khouri, S. Mulligan, H. A. Carty, R. T. Cline, S. E. Van Aken, J. Gill, M. Scarselli, M. Mora, E. T. Iacobini, C. Brettoni, G. Galli, M. Mariani, F. Vegni, D. Maione, D. Rinaudo, R. Rappuoli, J. L. Telford, D. L. Kasper, G. Grandi, and C. M. Fraser. 2002. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc. Natl. Acad. Sci. USA 99:12391- 12396.
44. Tomich, P. K., F. Y. An, and D. B. Clewell. 1980. Properties of erythromycin-inducible transposon Tn917 in Streptococcus faecalis. J. Bacteriol. 141:1366-1374.
45. Tomita, H., and D. B. Clewell. 2000. A pAD1-encoded small RNA molecule, mD, negatively regulates Enterococcus faecalis pheromone response by enhancing transcription termination. J. Bacteriol. 182:1062-1073.
46. Tomita, H., S. Fujimoto, K. Tanimoto, and Y. Ike. 1996. Cloning and genetic organization of the bacteriocin 31 determinant encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pYI17. J. Bacteriol. 178:3585-3593.
47. Tomita, H., S. Fujimoto, K. Tanimoto, and Y. Ike. 1997. Cloning and genetic and sequence analysis of the bacteriocin 21 determinant encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pPD1. J. Bacteriol. 179:7843-7855.
48. Tomita, H., and Y. Ike. 2005. Genetic analysis of transfer-related regions of the vancomycin resistance Enterococcus conjugative pHTβ: identification of oriT and a putative relaxase gene. J. Bacteriol. 187:7727-7737.
49. Tomita, H., C. Pierson, S. K. Lim, D. B. Clewell, and Y. Ike. 2002. Possible connection between a widely disseminated conjugative gentamicin resistance(pMG1-like) plasmid and the emergence of vancomycin resistance in Enterococcus faecium. J. Clin. Microbiol. 40:3326-3333.
50. Wirth, R., F. Y. An, and D. B. Clewell. 1986. Highly efficient protoplast transformation system for Streptococcus faecalis and a new Escherichia coli-S. faecalis shuttle vector. J. Bacteriol. 165:831-836.
51. Wren, B. W. 1991. A family of clostridial and streptococcal ligand-binding proteins with conserved C-terminal repeat sequences. Mol. Microbiol. 5:797-803.