Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit

Clinical Orthopaedics and Related Research

Volumn 425, Issue , 2004, Pages 237-243

  Lattermann, Christian ^a,b,d   Baltzer, Axel W ^b,c   Zelle, Boris A ^a   Whalen, Janey D ^a   Niyibizi, Christopher ^a   Robbins, Paul D ^b   Evans, Christopher H ^a,b   Gruen, Gary S ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; GROWTH FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEASIBILITY STUDY; FRACTURE HEALING; FRACTURE NONUNION; GENE EXPRESSION; GENE TRANSFER; INJECTION; MARKER GENE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RELIABILITY; REPRODUCIBILITY; TIBIA; TRANSGENE; VIRAL GENE THERAPY;

EID: 4043120514     PISSN: 0009921X     EISSN: 15281132     Source Type: Journal    
DOI: 10.1097/00003086-200408000-00034     Document Type: Article

References (33)

1. Baltzer AW, Lattermann C, Whalen JD, et al: A gene therapy approach to accelerating bone healing: Evaluation of gene expression in a New Zealand White rabbit model. Knee Surg Sports Traumatol Arthrosc 7:197-202, 1999.
2. Baltzer AWA, Lattermann C, Whalen JD, et al: Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 7:734-739, 2000.
3. Beaver R, Brinker MR, Barrack RL: An analysis of the actual cost of tibial nonunions. J La State Med Soc 149:200-206, 1997.
4. Bostrom M, Lane JM, Tomin E, et al: Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model. Clin Orthop 327:272-282, 1996.
5. Brighton CT, Black J, Friedenberg ZB, et al: A multicenter study of the treatment of nonunion with constant direct current. J Bone Joint Surg 63A:2-13, 1981.
6. Cook SD, Wolfe MW, Salkeld SL, Rueger DC: Effect of recombinant human osteogenic protein-1 on healing of segmental defects in non-human primates. J Bone Joint Surg 77A:734-750, 1995.
7. Franceschi RT, Wang D, Krebsbach PH, Rutherford RB: Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J Cell Biochem 78:476-486, 2000.
8. Friedlaender GE, Perry CR, Cole JD, et al: Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg 83A(Suppl):S151-S158, 2001.
9. Geesink RG, Hoefnagels NH, Bulstra SK: Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg 81B:710-718, 1999.
10. Gerich TG, Kang R, Fu FH, Robbins PD, Evans CH: Gene transfer to the patellar tendon. Knee Surg Sports Traumatol Arthrosc 5:118-123, 1997.
11. Ghivizzani SC, Lechman ER, Tio C, et al: Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy. Gene Ther 4:977-982, 1997.
12. Govender S, Csimma C, Genant HK, et al: Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg 84A:2123-2134, 2002.
13. Heckmann JD, Sarasohn-Kahn J: The economics of treating tibia fractures: The cost of delayed unions. Bull Hosp Jt Dis 56:63-72, 1997.
14. Hietaniemi K, Peltonen J, Paavolainen P: An experimental model for nonunion in rats. Injury 26:681-686, 1995.
15. Huard J, Krisky D, Oligino T, et al: Gene transfer to muscle using herpes simplex virus-based vectors. Neuromuscul Disord 7:299-313, 1997.
16. Johnson EE, Urist MR, Finerman GAM: Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein: A preliminary report. Clin Orthop 236:249-257, 1988.
17. Johnson EE, Urist MR, Schmalzried TP, et al: Autogeneic cancellous bone grafts in extensive segmental ulnar defects in dogs: Effects of xenogeneic bovine bone morphogenetic protein without and with interposition of soft tissues and interruption of blood supply. Clin Orthop 249:254-265, 1989.
18. Knighton DR, Ciresi KF, Fiegel VD, Austin LL, Butler L: Classification and treatment of chronic nonhealing wounds: Successful treatment with autologous platelet-derived wound healing factors (PDWHF). Ann Surg 204:322-330, 1986.
19. Liebermann JR, Le LQ, Wu L, et al: Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 16:330-339, 1988.
20. Miclau T, Lindsey RW, Probe R, Rahn BA, Perren SM: Autogenous cancellous bone graft incorporation in a gap defect in the canine femur. J Orthop Trauma 10:108-113, 1996.
21. Moeller ME, Thomas RJ: Treatment of nonunion in fractures of long bones. Clin Orthop 138:141-153, 1979.
22. Moxham JP, Kibblewhite DJ, Dvorak M, et al: TGF-beta 1 forms functionally normal bone in a segmental sheep tibial diaphyseal defect. J Otolaryngol 25:388-392, 1996.
23. Niyibizi C, Baltzer AWA, Lattermann C, et al: Potential role for gene therapy in the augmentation of fracture healing. Clin Orthop 355(Suppl):S148-S153, 1998.
24. Oni OO: A nonunion model of the rabbit tibial diaphysis. Injury 26:619-622, 1995.
25. Praemer A, Furner S, Rice D: Musculoskeletal Conditions in the United States. Park Ridge, IL, American Academy of Orthopaedic Surgeons 1992.
26. Schmilz JP, Hollinger JO: The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop 205:299-308, 1986.
27. Sciadini MF, Dawson JM, Johnson KD: Bovine-derived bone protein as a bone graft substitute in a canine segmental defect model. J Orthop Trauma 11:496-508, 1997.
28. Taylor C: Delayed Union and Nonunion in Fractures. In Crenshaw AH (ed). Campbell's Operative Orthopaedics. St Louis, Mosby Year Book Inc 85-124, 1992.
29. Tiedeman JJ, Connolly JF, Strates BS, Lippiello L: Treatment of nonunion by percutaneous injection of bone marrow and demineralized bone matrix: An experimental study in dogs. Clin Orthop 268:294-302, 1991.
30. Toombs JP, Wallace LJ: Evaluation of autogeneic and allogeneic cortical chip grafting in a feline tibial nonunion model. Am J Vet Res 46:519-528, 1985.
31. Vogel J, Hopf C, Eysel P, Rompe JD: Application of extracorporal shock-waves in the treatment of pseudarthrosis of the lower extremity. Arch Orthop Trauma Surg 116:480-483, 1997.
32. Yasko AW, Lane JM, Fellinger EJ, et al: The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2): A radiographic, histological, and biomechanical study in rats. J Bone Joint Surg 74A:659-670, 1992.
33. Zegzula HD, Buck DC, Brekke J, Wozney JM, Hollinger JO: Bone formation with use of rhBMP-2. J Bone Joint Surg 79A:1778-1790, 1997.