Mn2+ ions reduce the enzymatic and pharmacological activities of bothropstoxin-I, a myotoxic Lys49 phospholipase A2 homologue from Bothrops jararacussu snake venom

International Journal of Biochemistry and Cell Biology

Volumn 34, Issue 6, 2002, Pages 668-677

  Soares, Andreimar M ^a,b   Oshima Franco, Yoko ^c   Vieira, Carlos A ^a   Leite, Gildo B ^c   Fletcher, Jeffrey E ^d,e   Jiang, M S ^d   Cintra, Adelia C O ^a   Giglio, José R ^a   Rodrigues Simioni, Léa ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF RIBEIRÃO PRETO   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e Trinity Communications   (United States)

Author keywords

Bothrops jararacussu; Bothropstoxin I; Mn2+ ions; Phospholipase A2; Snake venom

Indexed keywords

BOTHROPSTOXIN 1; CATION; MANGANESE; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; EDEMA; ENZYME ACTIVITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; INCUBATION TIME; LYSIS; MUSCLE NECROSIS; NEUROMUSCULAR BLOCKING; NONHUMAN; PHRENIC NERVE; SNAKE; TOXICITY;

ANIMALS; BOTHROPS; CATIONS, DIVALENT; CELL SURVIVAL; CROTALID VENOMS; DIAPHRAGM; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; INJECTIONS, INTRAMUSCULAR; KINETICS; LIPIDS; MALE; MANGANESE; MICE; MUSCLE, SKELETAL; NECROSIS; NEUROBLASTOMA; NEUROMUSCULAR BLOCKADE; PHOSPHOLIPASES A; PHRENIC NERVE; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED;

BOTHROPS; BOTHROPS JARARACUSSU; SERPENTES;

EID: 0036217615     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(01)00174-1     Document Type: Article

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