Comparing the fixed combination dorzolamide-timolol (Cosopt®) to concomitant administration of 2% dorzolamide (Trusopt®) and 0.5% timolol - A randomized controlled trial and a replacement study

Journal of Clinical Pharmacy and Therapeutics

Volumn 29, Issue 4, 2004, Pages 375-380

  Francis, B A ^a   Du, L T ^a   Berke, S ^b   Ehrenhaus, M ^b   Minckler, D S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b OPHTHALMIC CONSULTANTS OF LONG ISLAND   (United States)

Author keywords

Combination therapy; Dorzolamide; Glaucoma; Timolol

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRIMONIDINE; CARBONATE DEHYDRATASE INHIBITOR; DIPIVEFRINE; DORZOLAMIDE; DORZOLAMIDE PLUS TIMOLOL; LATANOPROST; PILOCARPINE; TIMOLOL;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG FORMULATION; FEMALE; GLAUCOMA; HUMAN; INTRAOCULAR HYPERTENSION; INTRAOCULAR PRESSURE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPEN ANGLE GLAUCOMA; PRESSURE MEASUREMENT; PSEUDOEXFOLIATION; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE;

AGED; ANTIHYPERTENSIVE AGENTS; CARBONIC ANHYDRASE INHIBITORS; DRUG COMBINATIONS; DRUG THERAPY, COMBINATION; FEMALE; GLAUCOMA; HUMANS; INTRAOCULAR PRESSURE; MALE; PROSPECTIVE STUDIES; SULFONAMIDES; THIOPHENES; TIMOLOL;

EID: 4043077710     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2004.00574.x     Document Type: Article

References (10)

1. Boyle JE, Ghosh K, Gieser DK, Adamsons IA (1998) A randomized trial comparing the dorzolamide-timolol combination given twice daily to monotherapy with timolol and dorzolamide. Ophthalmology, 105, 1945-1951.
2. Strohmaier K, Snyder E, Dubiner H, Adamsons IA (1998) The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components. Ophthalmology, 105, 1936-1944.
3. Clineschmidt CM, Williams RD, Snyder E, Adamsons IA (1998) A randomized trial in patients inadequately controlled with timolol alone comparing the dorzolamide-timolol combination to monotherapy with timolol or dorzolamide. Ophthalmology, 105, 1952-1959.
4. Hutzelmann J, Owens S, Shedden A, Adamsons I, Vargas E (1998) Comparison of the safety and efficacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study. British Journal of Ophthalmology, 82, 1249-1253.
5. Choudri S, Wand M, Shields MB (2000) A comparison of dorzolamide-timolol combination versus the concomitant drugs. American Journal of Ophthalmology, 130, 832-833.
6. Strahlman E, Tipping R, Vogel R (1995) A double-masked, randomized 1-year study comparing dorzolamide (Trusopt), timolol, and betaxolol. International Dorzolamide Study Group. Archives of Ophthalmology, 113, 1009-1016.
7. Long DA, Gordon EJ (1988) Levobunolol and betaxolol: a double-masked controlled comparison of efficacy and safty in patients with elevated intraocular pressure. Ophthalmology, 95, 735-741.
8. Allen RC, Hertzman E, Walker AM, Epstein DL (1986) A double-masked comparison of betaxolol vs timolol in the treatment of open-angle glaucoma. American Journal of Ophthalmology, 101, 535-541.
9. Martone J, Mead A (2001) Combination treatment may improve efficacy. Review of Ophthalmology, 8, 82-84.
10. Morgan TO, Nowson C, Murphy J, Snowden R (1986) Compliance and the elderly hypertensive. Drugs, 31(Suppl. 4), 174-183.