The angiotensin-I converting enzyme I/D polymorphism is not associated with type 2 diabetes in individuals undergoing coronary angiography. (The Ludwigshafen Risk and Cardiovascular Health Study)

Molecular Genetics and Metabolism

Volumn 88, Issue 4, 2006, Pages 378-383

  Grammer, Tanja B ^a   Renner, Wilfried ^a   von Karger, Sabine ^b   Boehm, Bernhard O ^c   Winkelmann, Bernhard R ^d   Maerz, Winfried ^e  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d Cardiology Group Frankfurt Sachsenhausen   (Germany)

^e SYNLAB ACADEMY   (Germany)

Author keywords

Angiotensin I converting enzyme; Coronary heart disease; Genetics; Glucose; Myocardial infarction; Type 2 diabetes mellitus

Indexed keywords

ACETYLSALICYLIC ACID; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C PEPTIDE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HEMOGLOBIN A1C; INSULIN; ORAL ANTIDIABETIC AGENT; PROINSULIN;

ADULT; AGE DISTRIBUTION; AGED; ALLELE; ANGIOCARDIOGRAPHY; ANGIOTENSIN I CONVERTING ENZYME GENE; ARTICLE; CARDIOVASCULAR RISK; CAUCASIAN; CONFIDENCE INTERVAL; CONTROLLED STUDY; DIET THERAPY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; GLUCOSE METABOLISM; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; SEX RATIO;

AGED; ALLELES; CASE-CONTROL STUDIES; CORONARY ANGIOGRAPHY; CORONARY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; GENOME, HUMAN; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PEPTIDYL-DIPEPTIDASE A; POLYMORPHISM, GENETIC;

EID: 33746271080     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2006.01.008     Document Type: Article

References (16)

1. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., and Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels. J. Clin. Invest. 86 (1990) 1343-1346
2. Agerholm-Larsen B., Nordestgaard B.G., and Tybjaerg-Hansen A. ACE gene polymorphism in cardiovascular disease: meta-analyses of small and large studies in whites. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 484-492
3. Stephens J.W., Dhamrait S.S., Cooper J.A., Acharya J., Miller G.J., Hurel S.J., and Humphries S.E. The D allele of the ACE I/D common gene variant is associated with Type 2 diabetes mellitus in Caucasian subjects. Mol. Genet. Metab. 84 (2005) 83-89
4. Winkelmann B.R., März W., Boehm B.O., Zotz R., Hager J., Hellstern P., and Senges J. Rationale and design of the LURIC study-a resource for functional genomics, pharmacogenomics, and long-term prognosis of cardiovascular disease. Pharmacogenomics 2 (2001) S1-S73
5. Austen W.G., Edwards J.E., Frye R.L., Gensini C.G., Gott V.L., Griffith L.S.C., McGoon D.C., Murphy M.C., and Roe B.B. A reporting system on patients evaluated for coronary artery disease. Report of the ad hoc committee for grading of coronary artery disease. Circulation 50 (1975) 7-40
6. Rigat B., Hubert C., Corvol P., and Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acid Res. 20 (1992) 1433
7. Shanmugam V., Sell K.W., and Saha B.K. Mistyping ACE heterozygotes. PCR Methods Appl. 3 (1993) 120-121
8. American Diabetes Association, Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, Diabetes Care 20 (1997) 1183-97.
9. Levy J.C., Matthews D.R., and Hermans M.P. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21 (1998) 2191-2192
10. Keavney B., McKenzie C., Parish S., Palmer A., Clark S., Youngman L., Delepine M., Lathrop M., Peto R., and Collins R. Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators. Lancet 355 (2000) 434-442
11. Pfeffer M.A., Swedberg K., Granger C.B., Held P., McMurray J.J., Michelson E.L., Olofsson B., Ostergren J., Yusuf S., and Pocock S. Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme. Lancet 362 (2003) 759-766
12. Lithell H., Hansson L., Skoog I., Elmfeldt D., Hofman A., Olofsson B., Trenkwalder P., and Zanchetti A. The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial. J. Hypertens. 21 (2003) 875-886
13. Vermes E., Ducharme A., Bourassa M.G., Lessard M., White M., and Tardif J.C. Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD). Circulation 107 (2003) 1291-1296
14. Sharma A.M. Is there a rationale for angiotensin blockade in the management of obesity hypertension?. Hypertension 44 (2004) 12-19
15. Hauner H., Koster I., and von Ferber L. [Prevalence of diabetes mellitus in Germany 1998-2001. Secondary data analysis of a health insurance sample of the AOK in Hesse/KV in Hessen]. Dtsch. Med. Wochenschr 128 (2003) 2632-2637
16. Taubert G., Winkelmann B.R., Schleiffer T., Marz W., Winkler R., Gok R., Klein B., Schneider S., and Boehm B.O. Prevalence, predictors, and consequences of unrecognized diabetes mellitus in 3266 patients scheduled for coronary angiography. Am. Heart J. 145 (2003) 285-291