Venous thromboembolism prophylaxis for the general surgical patient: Where do we stand?

Seminars in Respiratory and Critical Care Medicine

Volumn 29, Issue 1, 2008, Pages 83-89

  Petralia, Gloria A ^a,b   Kakkar, Ajay K ^a,b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

Author keywords

Compression stockings; Critical care; Heparin; Intermittent pneumatic compression devices; Low molecular weight heparin; Prevention; Pulmonary embolism; Surgery; Thromboembolism clothing; Venous thrombosis

Indexed keywords

HEPARIN; LOW MOLECULAR WEIGHT HEPARIN;

COMPRESSION GARMENT; DISABILITY; DRUG EFFICACY; DRUG SAFETY; FATALITY; HOSPITAL READMISSION; HUMAN; INCIDENCE; INTERMITTENT PNEUMATIC COMPRESSION DEVICE; LOW DRUG DOSE; MOBILIZATION; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SURGICAL PATIENT; THROMBOSIS PREVENTION; VENOUS THROMBOEMBOLISM;

ANTICOAGULANTS; CRITICAL CARE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; POSTOPERATIVE COMPLICATIONS; PULMONARY EMBOLISM; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; VENOUS THROMBOEMBOLISM;

EID: 40349101955     PISSN: 10693424     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1047566     Document Type: Review

References (62)

1. Kakkar VV, Corrigan T, Spindler J, et al. Efficacy of low doses of heparin in prevention of deep-vein thrombosis after major surgery: a double-blind, randomised trial. Lancet 1972;2:101-106
2. Caprini JA, Arcelus JI, Hoffman K, et al. Prevention of venous thromboembolism in North America: results of a survey among general surgeons. J Vasc Surg 1994;20:751-758
3. Anderson FA Jr, Wheeler HB, Goldberg RJ, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 1991;151:933-938
4. The National Collaborating Centre for Acute Care. Surgical Risk in: Venous Thromboembolism. Reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients undergoing surgery. National Collaborating Centre for Acute Care at The Royal College of Surgeons of England; 2007:42-52
5. Lindblad B, Eriksson A, Bergqvist D. Autopsy-verified pulmonary embolism in a surgical department: analysis of the period from 1951 to 1988. Br J Surg 1991;78:849-852
6. Sandler DA, Martin JF. Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med 1989;82:203-205
7. White RH, Zhou H, Romano PS. Incidence of symptomatic venous thromboembolism after different elective or urgent surgical procedures. Thromb Haemost 2003;90:446-455
8. Kakkar VV, Howe CT, Flanc C, Clarke MB. Natural history of postoperative deep-vein thrombosis. Lancet 1969;2:230-232
9. Kearon C. Natural history of venous thromboembolism. Circulation 2003;107(23, Suppl 1):I22-I30
10. Agnelli G, Cosmi B, Radicchia S, et al. Features of thrombi and diagnostic accuracy of impedance plethysmography in symptomatic and asymptomatic deep vein thrombosis. Thromb Haemost 1993;70:266-269
11. Stein PD, Henry JW. Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest 1995;108:978-981
12. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126(Suppl 3):338S-400S
13. Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in fatal pulmonary embolism and venous thrombosis by perioperative administration of subcutaneous heparin: overview of results of randomized trials in general, orthopedic, and urologic surgery. N Engl J Med 1988;318:1162-1173
14. Shojania KG, Duncan BW, McDonald KM, Wachter RM, Markowitz AJ. Making health care safer: a critical analysis of patient safety practices. Evid Rep Technol Assess (Summ) 2001(43):i-x, 1-668
15. Kakkar VV, Cohen AT, Edmonson RA, et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. The Thromboprophylaxis Collaborative Group. Lancet 1993;341:259-265
16. Bick RL. Proficient and cost-effective approaches for the prevention and treatment of venous thrombosis and thromboembolism. Drugs 2000;60:575-595
17. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet 1999;353:1167-1173
18. Kakkar VV, Howe CT, Nicolaides AN, Renney JT, Clarke MB. Deep vein thrombosis of the leg: is there a "high risk" group? Am J Surg 1970;120:527-530
19. Rahr HB, Sorensen JV. Venous thromboembolism and cancer. Blood Coagul Fibrinolysis 1992;3:451-460
20. Petralia G, McManus A, Kakkar A. Thromboprophylaxis in cancer surgery. In: Khorana A, Francis CW, eds. Cancer-Associated Thrombosis: New Findings in Translational Science, Prevention and Treatment. 1st ed. New York: Informa Healthcare; 2007:193-202
21. Petralia P, Kakkar AK. Antithrombotic therapy with low molecular weight heparin in cancer patients [review]. Eur J Med Res 2004;9:119-124
22. Walsh JJ, Bonnar J, Wright FW. A study of pulmonary embolism and deep vein thrombosis after major gynaecological surgery using labelled fibrinogen-phlebography and lung scanning. J Obstet Gynaecol Br Commonw 1974;81:311-316
23. Hills NH, Pflug JJ, Jeyasingh K, Boardman L, Calnan JS. Prevention of deep vein thrombosis by intermittent pneumatic compression of calf. BMJ 1972;1:131-135
24. Rosenberg IL, Evans M, Pollock AV. Prophylaxis of postoperative deep vein thrombosis [letter]. Br Med J 1975;3:228
25. Rem J, Duckert F, Fridrich R, Gruber UF. Subcutaneous small heparin doses for the prevention of thrombosis in general surgery and urology. Schweiz Med Wochenschr 1975;105:827-835
26. Gallus AS, Hirsh J, O'Brien SE, McBride JA, Tuttle RJ, Gent M. Prevention of venous thrombosis with small, subcutaneous doses of heparin. JAMA 1976;235:1980-1982
27. Allan A, Williams JT, Bolton JP, Le Quesne LP. The use of graduated compression stockings in the prevention of post-operative deep vein thrombosis. Br J Surg 1983;70:172-174
28. The Multicenter Trial Committee. Dihydroergotamine-heparin prophylaxis of postoperative deep vein thrombosis: a multicenter trial. JAMA 1984;251:2960-2966
29. Kakkar VV, Murray WJ. Efficacy and safety of low-molecular-weight heparin (CY216) in preventing postoperative venous thrombo-embolism: a cooperative study. Br J Surg 1985;72:786-791
30. Sue-Ling HM, Johnston D, McMahon MJ, Philips PR, Davies JA. Preoperative identification of patients at high risk of deep venous thrombosis after elective major abdominal surgery. Lancet 1986;1:1173-1176
31. Tsai AW, Cushman M, Rosamond WD, Heckbert SR, Polak JF, Folsom AR. Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology. Arch Intern Med 2002;162:1182-1189
32. Hendolin H, Mattila MA, Poikolainen E. The effect of lumbar epidural analgesia on the development of deep vein thrombosis of the legs after open prostatectomy. Acta Chir Scand 1981;147:425-429
33. Jaffer AK, Barsoum WK, Krebs V, Hurbanek JG, Morra N, Brotman DJ. Duration of anesthesia and venous thromboembolism after hip and knee arthroplasty. Mayo Clin Proc 2005;80:732-738
34. Riber C, Alstrup N, Nymann T, Bogstad JW, Wille-Jorgensen P, Tonnesen H. Postoperative thromboembolism after day-case herniorrhaphy. Br J Surg 1996;83:420-421
35. Samama CM, Albaladejo P, Benhamou D, et al. Venous thromboembolism prevention in surgery and obstetrics: clinical practice guidelines. Eur J Anaesthesiol 2006;23:95-116
36. Lindberg F, Bergqvist D, Rasmussen I. Incidence of thromboembolic complications after laparoscopic cholecystectomy: review of the literature. Surg Laparosc Endosc 1997;7:324-331
37. Bergqvist D, Matzsch T, Jendteg S, Lindgren B, Persson U. The cost-effectiveness of prevention of post-operative thromboembolism. Acta Chir Scand Suppl 1990;556:36-41
38. Lind T. Changing surgical principles for gastro-oesophageal reflux disease: is laparoscopic fundoplication justified in the light of surgical complications? Eur J Surg Suppl 2000;585:31-33
39. Mall JW, Schwenk W, Rodiger O, Zippel K, Pollmann C, Muller JM. Blinded prospective study of the incidence of deep venous thrombosis following conventional or laparoscopic colorectal resection. Br J Surg 2001;88:99-100
40. Hamad GG, Choban PS. Enoxaparin for thromboprophylaxis in morbidly obese patients undergoing bariatric surgery: findings of the prophylaxis against VTE outcomes in bariatric surgery patients receiving enoxaparin (PROBE) study. Obes Surg 2005;15:1368-1374
41. Gugliotti DV. What is the optimal venous thromboembolism prophylaxis for patients undergoing bariatric surgery? IMPACT consults. Proceedings of the 2nd Annual Cleveland Clinic Perioperative Medicine Summit. Cleve Clin J Med 2006;73(Electronic Suppl 1):S17-S18
42. Westling A, Bergqvist D, Bostrom A, Karacagil S, Gustavsson S. Incidence of deep venous thrombosis in patients undergoing obesity surgery. World J Surg 2002;26:470-473
43. Prystowsky JB, Morasch MD, Eskandari MK, Hungness ES, Nagle AP. Prospective analysis of the incidence of deep venous thrombosis in bariatric surgery patients. Surgery 2005;138:759-763; discussion 763-765
44. Huber O, Bounameaux H, Borst F, Rohner A. Postoperative pulmonary embolism after hospital discharge: an underestimated risk. Arch Surg 1992;127:310-313
45. Heit JA, O'Fallon WM, Petterson TM, et al. Relative impact of risk factors for deep vein thrombosis and pulmonary embolism: a population-based study. Arch Intern Med 2002;162:1245-1248
46. Bergqvist D, Agnelli G, Cohen AT, et al. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer. [see comment] N Engl J Med 2002;346:975-980
47. Abrams CS, Ellison N, Budzynski AZ, Shattil SJ. Direct detection of activated platelets and platelet-derived microparticles in humans. Blood 1990;75:128-138
48. Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg 1999;86:992-1004
49. Haas SB, Tribus CB, Insall JN, Becker MW, Windsor RE. The significance of calf thrombi after total knee arthroplasty. J Bone Joint Surg Br 1992;74:799-802
50. Kalodiki E, Domjan J, Nicolaides AN, et al. V/Q defects and deep venous thrombosis following total hip replacement. Clin Radiol 1995;50:400-403
51. Hull RD, Pineo GF, Stein PD, et al. Extended out-of-hospital low-molecular-weight heparin prophylaxis against deep venous thrombosis in patients after elective hip arthroplasty: a systematic review. Ann Intern Med 2001;135:858-869
52. Eikelboom JW, Quinlan DJ, Douketis JD. Extended-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of the randomised trials. Lancet 2001;358:9-15
53. Mismetti P, Laporte S, Darmon JY, Buchmuller A, Decousus H. Meta-analysis of low molecular weight heparin in the prevention of venous thromboembolism in general surgery. [see comment]Br J Surg 2001;88:913-930
54. Douketis JD, Eikelboom JW, Quinlan DJ, Willan AR, Crowther MA. Short-duration prophylaxis against venous thromboembolism after total hip or knee replacement: a meta-analysis of prospective studies investigating symptomatic outcomes. Arch Intern Med 2002;162:1465-1471
55. Pulmonary Embolism Prevention (PEP) Trial Collaborative Group. Prevention of pulmonary embolism and deep vein thrombosis with low dose aspirin: Pulmonary Embolism Prevention (PEP) trial. Lancet 2000;355(9212):1295-1302
56. Zurawska U, Parasuraman S, Goldhaber SZ. Prevention of pulmonary embolism in general surgery patients. Circulation 2007;115:e302-e307
57. Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients: results of meta-analysis. Ann Surg 1988;208:227-240
58. Bergqvist D, Burmark US, Flordal PA, et al. Low molecular weight heparin started before surgery as prophylaxis against deep vein thrombosis: 2500 versus 5000 XaI units in 2070 patients. [see comment] Br J Surg 1995;82:496-501
59. Warkentin TE, Levine MN, Hirsh J, et al. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. [see comment] N Engl J Med 1995;332:1330-1335
60. Agnelli G, Bergqvist D, Gallus A, Gent M. A randomised double-blind study to compare the efficacy and safety of fondaparinux with deltaparin in the prevention of venous thromboembolism after high-risk abdominal surgery: the Pegasus study. J Thromb Haemost 2003;1(Suppl 1):OC006
61. Agnelli G, Bergqvist D, Cohen AT, Gallus AS, Gent M. Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery. Br J Surg 2005;92:1212-1220
62. Richardson W, Apelgren K, Earle D, Fanelli R. Guidelines for deep venous thrombosis prophylaxis during laparoscopic surgery. Surg Endosc 2007;21:2331-2334