Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage

Journal of Lipid Research

Volumn 40, Issue 3, 1999, Pages 533-542

  Amigo, Ludwig ^a   Mendoza, Hegaly ^a   Zanlungo, Silvana ^a   Miquel, Juan Francisco ^a   Rigotti, Attilio ^a   González, Sergio ^a   Nervi, Flavio ^a  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

Bile salts; Biliary lipids; Canaliculus; Cholesterol; Cytoprotection; Diosgenin; Maximal secretory rates; Membrane lipids; Plasma membrane; Sphingomyelin

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; DIOSGENIN; LACTATE DEHYDROGENASE; SPHINGOMYELIN; TAUROCHOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE TIME EFFECT RELATION; ENZYME RELEASE; HISTOPATHOLOGY; INTRAHEPATIC BILE DUCT; LIPID COMPOSITION; LIVER CELL MEMBRANE; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; MALE; MEMBRANE DAMAGE; NONHUMAN; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TRANSPORT KINETICS;

ALKALINE PHOSPHATASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE; BILE ACIDS AND SALTS; CELL FRACTIONATION; CELL MEMBRANE; CHOLESTEROL; DIOSGENIN; DISEASE MODELS, ANIMAL; L-LACTATE DEHYDROGENASE; LIPIDS; LIVER; MALE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; SPHINGOMYELINS; TAUROCHOLIC ACID;

EID: 0033008056     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Carey, M. C., and W. C. Duane. 1994. Enterohepatic circulation. In The Liver: Biology and Pathobiology. I. M. Arias, J. L. Boyer, N. Faust, W. B. Jacoby, D. Schachter, and D. A. Shafritz, editors. Raven Press Ltd., New York. 719-767.
2. Wheeler, H. O., and K. K. King. 1972. Biliary excretion of lecithin and cholesterol in the dog. J. Clin. Invest. 51: 1337-1350.
3. Hardison, W. G. M., and J. T. Apter. 1972. Micellar theory of biliary cholesterol excretion. Am. J. Physiol. 222: 61-67.
4. Yousef, I. M., S. Barnwell, F. Gratton, B. Tuchweber, A. Weber, and C. C. Roy. 1987. Liver cell membrane solubilization may control maximum secretory rate of cholic acid in the rat. Am. J. Physiol. 252: G84-G91.
5. Baumgartner, U., J. Schlmerich, P. Leible, and E. H. Farthmann. 1992. Cholestasis, metabolism and biliary lipid secretion during perfusion of rat liver with different bile salts. Biochim. Biophys. Acta. 1125: 142-149.
6. Güldütuna, S., G. Zimmer, M. Imhof, S. Bhatti, and U. Leuschner. 1993. Molecular aspects of membrane stabilization by ursodeoxycholate. Gastroenterology. 104: 1736-1744.
7. Coleman, R., S. Iqbal, P. P. Godfrey, and D. Billington. 1979. Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties. Biochem. J. 178: 201-208.
8. Barnwell, S. G., P. J. Lowe, and R. Coleman. 1983. Effect of taurochenodeoxycholate or tauroursodeoxycholate upon biliary output of phospholipids and plasma-membrane enzymes and the extent of cell damage in isolated perfused rat livers. Biochem. J. 216: 107-111.
9. Schlmerich, J., M. S. Becher, K. Schmidt, B. Kremer, S. Feldhaus, and W. Gerok. 1984. Influence of hydroxylation and conjugation of bile salts on isolated hepatocytes and lipid membrane vesicles. Hepatology. 4: 661-666.
10. Heuman, D. M., W. M. Pandak, P. B. Hylemon, and Z. R. Vlahcevic. 1991. Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: in vitro studies in rat hepatocytes and human erythrocytes. Hepatology. 14: 920-926.
11. Coleman, R. 1987. Bile salts and biliary lipids. Biochem. Soc. Trans. 15: 68S-80S.
12. Schmucker, D. L., M. Ohta, S. Kanai, Y. Sato, and K. Kitani. 1990. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology. 12: 1216-1221.
13. Lowe, P. J., and R. Coleman. 1981. Membrane fluidity and bile salt damage. Biochim. Biophys. Acta. 640: 55-65.
14. Velardi, A. L. M., A. K. Groen, R. P. J. Oude Elferink, R. Van der Meer, G. Palasciano, and G. N. J. Tytgat. 1991. Cell type-dependent effect of phospholipid and cholesterol on bile salt cytotoxicity. Gastroenterology. 101: 457-464.
15. Puglielli, L., L. Amigo, L. Núñez, M. Arrese, A. Rigotti, J. Garrido, S. González, G. Mingrone, A. V. Greco, I., Accatino, and F. Nervi. 1994. Protective role of biliary cholesterol and phospholipid lamellae against bile acid-induced cell damage. Gastroenterology. 107: 244-254.
16. Smit, J. J. M., A. H. Schinkel, R. P. J. Oude Elferink, A. K. Groen, E. Wagenaar, L. Van Deemter, C. A. A. M. Mol, R. Ottenhoff, N. M. T. Van der Lugt, M. A. Van Roon, M. A. Van der Valk, G. J. A. Offerhaus, A. J. M. Berns, and P. Borst. 1993. Homozygous disruption of the murine mdr2-P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell. 75: 451-462.
17. Mauad, T. H., C. M. J. van Nieuwkerk, K. P. Dingermans, J. J. M. Smit, A. H. Notemboom, M. A. van den Bergh Weerman, R. P. Verkruisen, A. K. Groen, R. P. F. Oude Elferink, M. A. Borst, and G. J. A. Offerhaus. 1994. Mice with disruption of the mdr2 P-glycoprotein gene: a novel animal model for studies of non-suppurative inflammatory cholangitis and hepatic carcinogenesis. Am. J. Pathol. 145: 1237-1245.
18. Crawford, J. M. 1996. Role of vesicle-mediated transport pathways in hepatocellular bile secretion. Sem. Liver Dis. 16: 169-189.
19. Crawford, A. R., A. J. Smith, V. C. Hatch, R. P. Oude Elferink, P. Borst, and J. M. Crawford. 1997. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. J. Clin. Invest. 100: 2562-2567.
20. Small, D. 1970. The formation of gallstones. Adv. Int. Med. 16: 243-264.
21. Coleman, R., and K. Rahman. 1992 Lipid flow in bile formation. Biochem. J. 1125: 113-133.
22. Rigotti, A., L. Núñez., L. Amigo, L. Puglielli, J. Garrido, M. Santos, S. González, G. Mingrone, A. Greco, and F. Nervi. 1993. Biliary lipid secretion: immunolocalization and identification of a protein associated with lamellar cholesterol carriers in supersaturated rat and human bile. J. Lipid Res. 34: 1883-1894.
23. Rigotti, A., M. P. Marzolo, N. Ulloa, O. Gonzalez, and F. Nervi. 1989. Effect of bean intake on biliary lipid secretion and on hepatic cholesterol metabolism in the rat. J. Lipid Res. 30: 1041-1048.
24. Nervi, F., R. Del Pozo, C. F. Covarrubias, and B. O. Ronco. 1983. The effect of progesterone on the regulatory mechanisms of biliary cholesterol secretion in the rat. Hepatology. 3: 360-367.
25. Nervi, F., M. Bronfman, W. Allalon, E. Deperieux, and R. Del Pozo. 1984. Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification. J. Clin. Invest. 74: 2226-2237.
26. Weibel, E. R. 1979. Sterological Methods. Vol 1. Academic Press, London-New York-Toronto-San Francisco. 101-161.
27. de Duve, C., B. C. Pressmann, R. Gianetto, R. Wattiaux, and F. Appelmans. 1955. Tissue fractionation studies. VI. Intracellular distribution patterns of enzymes in rat-liver tissue. Biochem. J. 60: 604-617.
28. Bronfman, M., N. C. Inestrosa, F. Nervi, and F. Leighton. 1984. Acyl-CoA synthetase and the peroxisomal enzymes of β-oxidation in human liver. Biorhem. J. 224: 709-720.
29. Leelavathi, D. E., L. W. Estes, D. S. Feingold, and B. Lombardi. 1970. Isolation of a Golgi-rich fraction from rat liver. Biochim. Biophys. Acta. 211: 124-138.
30. Perelman, A., C. Abeijon, C. B. Hirschberg, N. C. Inestroza, and E. Brandán. 1990. Differential association and distribution of acetyl-and butyrylcholinesterases within rat liver subcellular organelles. J. Biol. Chem. 265: 214-220.
31. Rosario, J., E. Sutherland, L. Zaccaro and F. R. Simon. 1988. Ethinylestradiol administration selectively alters liver sinusoidal membrane lipid fluidity and protein composition. Biochemistry. 27: 3993-3946.
32. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193: 265-275.
33. Jungalwala, F. B., J. E. Evans, and R. H. McCluer. 1976. High-performance liquid chromatography of phosphatidylcholine and sphingomyelin with detection in the region of 200 nm. Biochem. J. 155: 55-60.
34. Miquel, J. F., L. Núñez, L. Amigo, S. González, A. Raddatz, A. Rigotti, and F. Nervi. 1998. Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile. Gastroenterology. 114: 1016-1023.
35. Roman, L. M., and A. Hubbard. 1984. A domain-specific marker for the hepatocyte plasma membranes: localization of leucine aminopeptidase to the bile canalicular domain. J. Cell Biol. 96: 1548-1558.
36. Ismail-Beigi, F., and I. S. Edelman. 1971. The mechanism of the calorigenic action of thyroid hormone. Stimulation of Na-K-activated adenosine triphosphatase. J. Gen. Physiol. 57: 710-722.
37. Accatino, L., M. Pizarro, N. Solís, and C. Koenig. 1998. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Hepatology. 28: 129-140.
38. Slotte, J. P., M. I. Porn, and A. Härmälä. 1994. Flow and distribution of cholesterol - effects of phospholipids. Curr. Top. Membr. 40: 483-502.
39. Coleman, R., P. J. Lowe, and D. Billington. 1980. Membrane lipid composition and susceptibility to bile salt damage. Biochim. Biophys. Acta. 599: 294-300.
40. Roman, I. D., A. Thewles, and R. Coleman. 1995. Fractionation of livers following diosgenin treatment to elevate biliary cholesterol. Biochim. Biophys. Acta. 1255: 77-81.
41. Fielding, C. J., and P. E. Fielding. 1997. Intracellular cholesterol transport. J. Lipid Res. 38: 1503-1521.
42. Liscum, L., and N. K. Dahl. 1992. Intracellular cholesterol transport. J. Lipid Res. 33: 1239-1254.
43. Marzolo, M. P., and F. Nervi. 1989. Characterization of lipoprotein catabolism in biliary cholesterol hypersecretory states in the rat. Arch. Biol. Med. Exp. 22: 361-374.
44. Lange, Y., and B. V. Ramos. 1983. Analysis of the distribution of cholesterol in the intact cell. J. Biol. Chem. 258: 15130-15134.
45. Lange, Y. 1992. Tracking cell cholesterol with cholesterol oxidase. J. Lipid Res. 33: 315-321.
46. Schroeder, F., J. R. Jefferson, A. B. Kier, J. Knittel, T. J. Scallen, W. G. Wood, and Y. Happala. 1990. Transmembrane cholesterol distribution. In Advances in Cholesterol Research. M. Esfahany and J. Swaney, editors. Telford Press, Caldwell, NJ. 47-87.
47. Harder, T. and K. Simons. 1997. Caveolae, DIGS, and the dynamics of sphingolipid-cholesierol microdomains. Curr. Opin. Cell Biol. 9: 534-542.
48. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature. 387: 569-572.
49. Parton, R. G. 1996. Caveolae and caveolins. Curr. Opin. Cell Biol. 8: 542-548.
50. Puglielli, L., L. Núñez, A. Rigotti, A. V. Greco, M. J. Santos, and F. Nervi. 1995. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts. J. Biol. Chem. 270: 18723-18726.
51. Barnwell, S. G., B. Tuchweber, and I. M. Yousef. 1987. Biliary lipid secretion in the rat during infusion of increasing doses of unconjugated bile acids. Biochim. Biophys. Acta. 922: 221-233.
52. Puglielli, L., A. Rigotti, L. Amigo, L. Núñez, A. V. Greco, M. J. Santos, and F. Nervi. 1996. Modulation of intrahepatic cholesterol trafficking: evidence by in vivo antisense treatment for the involvement of sterol carrier protein-2 in newly synthesized cholesterol transport into bile, Biochem. J. 317: 681-687.
53. Ulloa, N., and F. Nervi. 1985. Mechanism and kinetic characteristics of the uncoupling by plant steroids of biliary cholesterol from bile salt output. Biochim. Biophys. Acta. 837: 181-189.
54. Amigo, L., M. P. Marzolo, J. M. Aguilera, A. Hohlberg, M. Cortés, and F. Nervi. 1992. Influence of different dietary constituents of beans (Phaseolus vulgaris) on serum and biliary lipids in the rat. J. Nutr. Biochem. 3: 486-490.
55. Nervi, F. C. Covarrubias, P. Bravo, N. Velasco, N. Ulloa, F. Cruz, M. Fava, C. Severín, R. Del Pozo, C. Antezana, V. Valdivieso, and A. Arteaga. 1989. Influence of legume intake on biliary lipids and cholesterol saturation in young Chilean men: identification of a dietary risk factor for cholesterol gallstone formation in a highly prevalent area. Gastroenterology. 96: 825-830.
56. Duane, W. C. 1997. Effects of legume consumption on serum cholesterol, biliary lipids, and sterol metabolism in humans. J. Lipid Res. 38: 1120-1128.