Laminin-332 promotes the invasion of oesophageal squamous cell carcinoma via PI3K activation

British Journal of Cancer

Volumn 98, Issue 5, 2008, Pages 974-980

  Baba, Y ^a,b   Iyama, K I ^b   Hirashima, K ^a   Nagai, Y ^a   Yoshida, N ^a   Hayashi, N ^a   Miyanari, N ^a   Baba, H ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Basement membrane; Laminin 332; Oesophageal cancer; PI3K pathway; Prognostic factor

Indexed keywords

ANTIBODY; KALININ; PHOSPHATIDYLINOSITOL 3 KINASE;

ADULT; ARTICLE; AUTOCRINE EFFECT; BASEMENT MEMBRANE; CANCER CELL CULTURE; CANCER INVASION; CANCER STAGING; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; ESOPHAGUS CARCINOMA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN SECRETION; SQUAMOUS CELL CARCINOMA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CARCINOMA, SQUAMOUS CELL; CELL ADHESION MOLECULES; CELL LINE, TUMOR; ESOPHAGEAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN BETA4; NEOPLASM INVASIVENESS; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 40349094778     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604252     Document Type: Article

References (32)

1. Beck K, Hunter I, Engel J (1990) Structure and function of laminin: anatomy of a multidomainglycoprotein. FASEB J 4: 148-160
2. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657
3. Carter WG, Kaur P, Gil SG, Gahr PJ, Wayner EA (1990) Distinct functions for integrins alpha3 beta1 in focal adhesions and alpha6 beta4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. J Cell Biol 111: 3141-3154
4. Carter WG, Ryan MC, Gahr PJ (1991) Epiligrin, a new adhesion ligand for integrin α3β1 in epithelial basement membranes. Cell 65: 599-619
5. Decline F, Rousselle P (2001) Keratinocyte migration requires alpha2beta1 integrin-mediated interaction with the laminin 5 gamma2 chain. J Cell Sci 114: 811-823
6. Engle J (1992) Laminins and other strange proteins. Biochemistry 31: 10643-10651
7. Enzinger PC, Mayer RJ (2003) Esophageal cancer. N Engl J Med 349: 2241-2252
8. Fresno Vara JA, Casado E, De Castro J, Cejas P, Belda-Iniesta C, González-Barón M (2004) PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30: 193-204
9. Fukai Y, Masuda N, Kato H, Fukuchi M, Miyazaki T, Nakajima M, Sohda M, Kuwano H, Nakajima T (2005) Correlation between Laminin-5 γ2 chain and Epidermal growth factor receptor expression in esophageal squamous cell carcinomas. Oncology 69: 71-80
10. Guo W, Pylayeva Y, Pepe A, Yoshioka T, Muller WJ, Inghirami G, Gianocotti FG (2006) Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorgenesis. Cell 126: 489-502
11. Hamilton SR, Aaltonen LA (2000) World Health Organization classification of tumours. Tumours of the Digestive System. Lyon: IARC Press
12. Kariya Y, Miyazaki K (2004) The basement membrane protein laminin-5 acts soluble cell motility factor. Exp Cell Res 297: 508-520
13. Koshikawa N, Moriyama K, Takamura H, Mizushima H, Nagashima Y, Yanoma S, Miyazaki K (1999) Overexpression of laminin γ2-chain monomer in invading gastric carcinoma cells. Cancer Res 59: 5596-5601
14. Luo J, Manning BD, Cantley LC (2003) Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4: 257-262
15. Marinkovich MP (2007) Laminin 332 in squamous-cell carcinoma. Nature Rev Cancer 7: 370-380
16. Matta M, Soini Y, Paakko P, Salo S, Tryggvason K, Autio-Harmainen H (1999) Expression of the laminin γ2 chain in different histological types of lung carcinoma. A study of immunohistochemistry and in situ hybridization. J Pathol 188: 361-368
17. Miyazaki K (2006) Laminin-5 (laminin-332) Unique biological activity and role in tumor growth and invasion. Cancer Sci 97: 91-98
18. Miyazaki K, Kikkawa Y, Nakamura A, Yasumitsu H, Umeda M (1993) A large cell-adhesive scatter factor secreted by human gastric carcinoma cells. Proc Natl Acad Sci USA 90: 508-520
19. Nguyen BP, Gil SG, Carter WG (2000) Deposition of laminin 5 by keratinocytes regulates integrin adhesion and signaling. J Biol Chem 275: 31896-31907
20. Nikolopoulos SN, Blaikie P, Yoshioka T, Guo W, Puri C, Tacchetti C, Giancotti FG (2005) Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Mol Cell Biol 25: 6090-6102
21. Ono Y, Nakanishi Y, Ino Y, Niki T, Yamada T, Yoshimura K, Saikawa M, Nakajima T, Hirohashi S (1999) Clinicopathologic significance of laminin γ2 chain in squamous cell carcinoma of the tangue: immunohistochamical analysis of 67 lesions. Cancer 85: 2315-2321
22. Pyke C, Salo S, Ralfikiaer E, Romer J, Dano K, Tryggvason K (1995) Laminin-5 is a marker of invading cancer cells in some human carcinomas and its coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 55: 4132-4139
23. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE (1991) Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol 114: 567-576
24. Ryan MC, Christiano AM, Enqvall E, Wewer UM, Miner JH, Sanes JR, Burqeson RE (1996) The functions of laminins: lessons from in vivo studies. Matrix Biol 15: 369-381
25. Schenk S, Hintermann E, Bilban M, Koshikawa N, Hojilla C, Khokha R, Quaranta V (2003) Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. J Cell Biol 161: 197-209
26. Sobin LH, Wittekind Ch (2002) TNM classification of malignant tumors, 6th ed New York: John Wiley & Sons Inc
27. Soini Y, Maatta M, Salo S, Tryggvason K, Autio-Harmainen H (1996) Expression of laminin γ2 chain in pancreatic adenocarcinoma. J Pathol 180: 290-294
28. Timpl R (1989) Structure and biological activity of basement membrane proteins. Eur J Biochem 180: 487-502
29. Vivanco J, Sawyers CL (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501
30. Waterman EA, Sakai N, Nguyen NT, Horst BA, Veitch DP, Dev CN, Ortiz-Urda S, Khavari PA, Marinkovich MP (2007) A laminin-collagen complex drives human epidermal carcinogenesis through phosphoinositol-3-kinase activation. Cancer Res 67: 4264-4270
31. Yamamoto H, Itoh F, Iku S, Hosokawa M, Imai K (2001) Expression of the γ2 chain of laminin-5 at the invasive front is associated with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Clin Cancer Res 7: 896-900
32. Yurchenco PD, Schittny JC (1990) Molecular architecture of basement membranes. FASEB J 4: 1577-1590