The L-arginine inhibition of rat middle cerebral artery contractile responses is mediated by inducible nitric oxide synthase

Journal of Autonomic Pharmacology

Volumn 18, Issue 2, 1998, Pages 105-113

  Alonso, M J ^a   Rodriguez Martinez M A ^a   Martinez Orgado J ^b   Marin J ^a   Salaices, M ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL VIRGEN DE LA LUZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DEXAMETHASONE; LIPOPOLYSACCHARIDE; NITRIC OXIDE SYNTHASE; POLYMYXIN B;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; MALE; MIDDLE CEREBRAL ARTERY; MUSCLE CONTRACTILITY; MUSCLE CONTRACTION; NONHUMAN; RAT;

EID: 0031867302     PISSN: 01441795     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2680.1998.1820105.x     Document Type: Article

References (46)

1. AISAKA, K., GROSS, S.S., GRIFFITH, O.W. & LEWI, R. (1989). L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. Biochem. Biophys. Res. Commun., 163, 710-717.
2. AMEZCUA, J.L., PALMER, R.M.J., DE SOUZA, B.M. & MONCADA, S. (1989). Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbit. Br. J. Pharmacol., 97, 1119-1124.
3. BERRAZUETA, J.R., SALAS, E., AMADO, J.A., SÁNCHEZ DE VEGA, M.J. & POVEDA, J.J. (1995). Induction of nitric oxide synthase in human mammary arteries in vitro. Eur. J. Pharmacol., 251, 303-305.
4. BRIAN, J.E., HEISTAD, D.D. & FARACI, F.M. (1995). Dilatation of cerebral arterioles in response to lipopolysaccharide in vivo. Stroke, 26, 277-281.
5. CHARPIE, J.R. & WEBB, R.C. (1993). Vascular myocite-derived nitric oxide is an autocrine that limits vasoconstriction. Biochem. Biophys. Res. Commun., 194, 763-768.
6. COLEMAN, R., SMITH, R.A. & NARUMIYA, S. (1994). International Union of Pharmacology classification of prostanoid receptors: properties, distribution and structure of the receptors and their subtypes. Pharmacol. Rev., 46, 205-209.
7. CREAGER, M.A., GALLAGHER, S.J., GIRERD, X.J., COLEMAN, S.M., DZAU, V.J. & COOKE, J.P. (1992). L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic human. J. Clin. Invest., 90, 1248-1253.
8. GOLD, M.E., BUSH, P.A. & IGNARRO, L.J. (1989). Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem. Biophys. Res. Commun., 164, 714-721.
9. + channels underlies relaxation to bacterial lipopolysaccharide in rat aorta. Biochem. Biophys. Res. Commun., 224, 184-190.
10. HIBBS, J.B., VAVRIN, Z.J.R. & TAINTOR, R.R. (1987). L-arginine is required for expression of the activated macrophages effector mechanism causing selective metabolic inhibition of target cells. J. Immunol., 138, 550-565.
11. HISHIKAWA, K., NAKAKI, T., SUZUKI, H., KATO, R. & SARUTA, T. (1993). Role of L-arginine-nitric oxide pathway in hypertension. J. Hypertens., 11, 639-645.
12. HISHIKAWA, K., NAKAKI, T., TSUDA, M., ESUMI, H., OHSHIMA, H., SUZUKI, H., SARUTA, T. & KATO, R. (1992). Effects of systemic L-arginine administration on hemodynamics and nitric oxide release in man. Jpn. Heart J., 33, 41-48.
13. JOVANOVIC, A., LEPOSAVA, G. & TULIC, I. (1994). L-arginine induces relaxation of human uterine artery with both intact or denuded endothelium. Eur. J. Pharmacol., 256, 103-107.
14. JULOU-SCHAEFFER, G., GRAY, G.A., FLEMING, I., SCHOTT, C., PARRAT, J.R. & STOCLET, J.C. (1990). Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway. Am. J. Physiol., 259, H1038-H1043.
15. G-monomethyl-L-arginine in canine basilar artery. Stroke, 22, 1399-1404.
16. KONTOS, H.A., WEI, E.P., KUKREJA, R.C., ELLIS, E.F. & HESS, M.L. (1990). Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine. Am. J. Physiol., 258, H1261-H1266.
17. LAING, R.L., JAKUBOWSKI, J. & MORICE, A.L. (1995). An in vitro study of the pharmacological responses of rat middle cerebral artery: Effects of overnight storage. J. Vasc. Res., 32, 230-236.
18. MARÍN, J. & RODRÍGUEZ MARTINEZ, M.A. (1997). Role of vascular nitric oxide in physiological and pathological conditions. Pharmacol. Ther., 75, 111-134.
19. MARTÍNEZ-ORGADO, J., SALAICES, M., RODRÍGUEZ-MARTÍNEZ, M.A., SÁNCHEZ-FERRER, C.F. & MARÍN, J. (1994). Role of nitric oxide on the endothelium-dependent vasodilation in newborn piglet cerebral arteries. Gen. Pharmacol., 25, 899-902.
20. MARTÍNEZ-ORGADO, J., SALAICES, M., RODRÍGUEZ-MARTÍNEZ, M.A., SÁNCHEZ-FERRER, C.F. & MARÍN, J. (1995). Age-related changes in nitric oxide-mediated vasodilation in cerebral arteries from newborn piglet cerebral arteries. Pharmaceut. Sci., 1, 35-37.
21. MCCALL, T.B., PALMER, R.M.J. & MONCADA, S. (1991). Induction of nitric oxide synthase in rat peritoneal neutrophils and its inhibition by dexamethasone. Eur. J. Immunol., 21, 2523-2527.
22. MICHIELSEN, P.P., BOECKXSTAENS, G.E., SYS, S.U., HERMAN, A.G. & PELCKMANS, P.A. (1995). Role of nitric oxide in hyporeactivity to noradrenaline of isolated aortic rings in portal hypertension. Eur. J. Pharmacol., 273, 167-174.
23. MITCHELL, J.A., KOHLHAAS, K.L., SORRENTINO, R. WARNER, T.D., MURAD, F. & VANE, J.R. (1993). Induction by endotoxin of nitric oxide synthase in the rat mesentery: lack of effect on action of vasoconstrictors. Br. J. Pharmacol., 109, 265-270.
24. MONCADA, S. & HIGGS, E.A. (1995). Molecular mechanisms and therapeutics strategies related to nitric oxide. FASEB J., 9, 1319-1330.
25. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142.
26. MORITOKI, H., TAKEUCHI, S., HISAYAMA, T. & KONDOH, W. (1992). Nitric oxide synthase responsible for L-arginine-induced relaxation of rat aortic rings in vitro may be an inducible type. Br. J. Pharmacol., 107, 361-366.
27. MORITOKI, H., UEDA, H., YAMAMOTO, T., HISAYAMA, T. & TAKEUCHI, S. (1991). L-arginine induces relaxation of rat aorta possibly through non-endothelial nitric oxide formation. Br. J. Pharmacol., 102, 841-846.
28. MULVANY, M.J. & HALPERN, W. (1976). Mechanical properties of vascular muscle cells in situ. Nature, 260, 617-619.
29. MULVANY, M.J. & HALPERN, W. (1977). Contractile properties of small arteries vessels in spontaneously hypertensive and normotensive rats. Circ. Res., 41, 19-26.
30. NAKAKI, T. & KATO, R. (1994). Beneficial circulatory effect of L-arginine. Jpn. J. Pharmacol., 66, 167-171.
31. ORALLO, F. (1996). Regulation of cytosolic calcium levels in vascular smooth muscle. Pharmacol. Ther., 69, 153-171.
32. OSOL, G., CIPOLLA, M. & KNUTSON, S. (1989). A new method for mechanically denuding the endothelium of small (50-150 μm) arteries with human hair. Blood Vessels, 26, 320-324.
33. PIEPER, G.M. & PELTIER, B.A. (1995). Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J. Cardiovasc. Pharmacol., 25, 397-403.
34. PUCI, M.L., DICK, L.B., MILLER, K.B., SMITH, C.J. & NASJLETTI, A. (1995). Enhanced responses to L-arginine in aortic rings from rats with angiotensin-dependent hypertension. J. Pharmacol. Exp. Ther., 274, 1-7.
35. RADOMSKI, M.W., PALMER, R.M.J. & MONCADA, S. (1990). Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA, 87, 10 043-10 047.
36. REES, D.D., CELLEK, S., PALMER, R.M.J. & MONCADA, S. (1990). Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock. Biochem. Biophys. Res. Commun., 173, 541-547.
37. RIEDEL, M.W., ANNESER, F. & HABERL, R.L. (1995). Different mechanisms of L-arginine induced dilation of brain arterioles in normotensive and hypertensive rats. Brain Res., 671, 21-26.
38. ROSENBLUM, W.I., NISHIMURA, H. & NELSON, G.H. (1990). Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone in brain microvessels. Am. J. Physiol., 259, H1396-H1401.
39. RUETTEN, H., SOUTHAN, G.J., ABATE, A. & THIEMERMANN, C. (1996). Attenuation of endotoxin-induced multiple organ dysfunction by 1-amino-2-hydroxy-guanidine, a potent inhibitor of inducible nitric oxide synthase. Br. J. Pharmacol., 118, 261-270.
40. SCHINI, V.B. & VANHOUTTE, P.M. (1991). L-Arginine evokes both endothelium-dependent and independent relaxations in L-Arginine depleted aortas. Circ. Res., 68, 209-216.
41. SCHNEIDER, F., SCHOTT, C., STOCLET, J.-C. & JULOU-SCHAEFFER, G. (1992). L-Arginine induces relaxation of small mesenteric atteries from endotoxin-treated rats. Eur. J. Pharmacol., 211, 269-272.
42. SCHOTT, C.A., GRAY, G.A. & STOCLET, J.-C. (1993). Dependence of endotoxin-induced vascular hyporeactivity on extracellular L-arginine. Br. J. Pharmacol., 108, 38-43.
43. UENO, M. & LEE, J.-F.T. (1993). Endotoxin decreases the contractile responses of the porcine basilar artery to vasoactive substances. J. Cer. Blood Flow Metabol., 13, 712-719.
44. VILLAMOR, E., PEREZ-VIZCAÍNO, F., RUIZ, T., LEZA. J.C., MORO, M. & TAMARGO, J. (1995). Group B Streptococcus and E. coli LPS-induced NO-dependent hyporesponsiveness to noradrenaline in isolated intrapulmonary arteries of neonatal piglets. Br. J. Pharmacol., 115, 261-266.
45. WOOD, K.S., BUGA, G.M., BYRNS, R.E. & IGNARRO, L.J. (1990). Vascular smooth muscle-derived relaxing factor (MDRF) and its close similarity to nitric oxide. Biochem. Biophys. Res. Commun., 170, 80-88.
46. YOON, H.J., JUN, C.D., KIM, J.M., RIM, G.M., KIM, H.M. & CHUNG, H.T. (1994). Phorbol ester synergistically increases interferon-gamma-induced nitric oxide synthesis in murine microglial cells. Neuroimmunomodulation, 1, 377-388.