Development and optimisation of a procedure for the production of Parapoxvirus ovis by large-scale microcarrier cell culture in a non-animal, non-human and non-plant-derived medium

Vaccine

Volumn 26, Issue 12, 2008, Pages 1552-1565

  Pohlscheidt, M ^a   Langer, U ^b   Minuth, T ^b   Bodeker B ^b   Apeler, H ^b   Horlein H D ^b   Paulsen, D ^c   Rubsamen Waigmann H ^c   Henzler, H J ^e   Reichl, U ^d  

^a ROCHE DIAGNOSTICS GMBH   (Germany)

^b BAYER PHARMA AG   (Germany)

^c AiCuris GmbH   (Germany)

^d MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^e NONE

Author keywords

Bovine kidney cell line; Microcarrier culture; Parapoxvirus; Volume Expanded Fed batch

Indexed keywords

LIVE VACCINE; RECOMBINANT HUMAN INSULIN; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSAFETY; CELL COUNT; CELL DENSITY; CELL EXPANSION; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DNA CONTENT; ELECTRON MICROSCOPY; FED BATCH CULTURE; HEPATITIS B; IMMUNOMODULATION; IMPELLER; MICROCARRIER CULTURE; MOUSE; NONHUMAN; PARAPOXVIRUS; PARAPOXVIRUS OVIS; PRIORITY JOURNAL; SUSPENSION CELL CULTURE; VIRUS CULTURE; VIRUS INACTIVATION; VIRUS PARTICLE; VIRUS PURIFICATION; VOLUME EXPANDED FED BATCH CULTURE;

ANIMALS; CATTLE; CELL COUNT; CELL SURVIVAL; CELLS, CULTURED; CULTURE MEDIA; DNA, VIRAL; HEPATITIS B; KIDNEY; MICE; MICE, TRANSGENIC; MICROSCOPY, ELECTRON; PARAPOXVIRUS; TRYPSIN; VACCINES, INACTIVATED;

EID: 40049111527     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.01.032     Document Type: Article

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