Diagnosis of 6 mercaptopurine hepatotoxicity post liver transplantation utilizing metabolite assays

American Journal of Transplantation

Volumn 4, Issue 9, 2004, Pages 1539-1542

  Kontorinis, Nickolas ^a   Agarwal, Kaushik ^a   Gondolesi, Gabriel ^a   Fiel, M Isabel ^b   O'Rourke, Marian ^a   Schiano, Thomas D ^a  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

6 methyl mercaptopurine; 6 thioguanine; Azathioprine; Cholestasis

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; DRUG METABOLITE; LIVER ENZYME; MERCAPTOPURINE; METHYLMERCAPTOPURINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; TACROLIMUS; THIOPURINE METHYLTRANSFERASE; TIOGUANINE; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; AUTOIMMUNE HEPATITIS; BIOASSAY; CASE REPORT; DIAGNOSTIC KIT; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG WITHDRAWAL; ENZYME BLOOD LEVEL; FEMALE; GENETIC POLYMORPHISM; GENETIC SCREENING; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; INTRAHEPATIC CHOLESTASIS; LIVER INJURY; LIVER TOXICITY; LIVER TRANSPLANTATION; METABOLITE ASSAY; MONITORING; ORGAN TRANSPLANTATION; PRIORITY JOURNAL; SOLID ORGAN TRANSPLANTATION;

6-MERCAPTOPURINE; BILIRUBIN; BIOTRANSFORMATION; COLORING AGENTS; FEMALE; HUMANS; LIVER; LIVER TRANSPLANTATION; METHYLTRANSFERASES; MIDDLE AGED; TREATMENT OUTCOME;

EID: 4344714821     PISSN: 16006135     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2004.00543.x     Document Type: Article

References (16)

1. Reich DJ, Fiel I, Guarrera JV et al. Liver transplantation for autoimmune hepatitis. Hepatology 2000; 32: 693-700.
2. Dervieux T, Medard Y, Baudouin V et al. Monitoring azathioprine therapy in pediatric renal transplant patients with red blood cell thiopurine methyltransferase. Transplant Proc 2000; 32: 361-363.
3. Lennard L. Assay of 6-thiosinic acid and 6-thioguanine nucleotides, active metabolites of of 6-mercaptopurine, in human red blood cells. J Chromatogr 1987; 423: 169-178.
4. Wiesner RH, Rakela J, Ishitani MB et al. Recent advances in liver transplantation. Mayo Clin Proc 2003; 78: 197-210.
5. Sterneck M, Wiesner R, Ascher N et al. Azathioprine hepatotoxicity after liver transplanation. Hepatology 1991; 14: 806-810.
6. Ramalho HJ, Terra EG, Cartapatti E et al. Hepatotoxicity of azathioprine in renal transplant recipients. Transplant Proc 1989; 21: 1716-1717.
7. Horsmans Y, Rahier J, Geubel AP. Reversible cholestasis with bile duct injury following azathioprine therapy. A case report. Liver 1991; 11: 89-93.
8. Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245.
9. Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32: 651-662.
10. Dubinsky MC, Lamothe S, Yang HY et al. Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease. Gastroenterology 2000; 118: 705-713.
11. Dubinsky MC, Yang H, Hassard PV et al. 6-MP metabolite profiles provide a biochemical explanation for 6MP resistance in patients with inflammatory bowel disease. Gastroenterology 2002; 122: 904-915.
12. Lennard L. The clinical pharmacology of 6-mercaptopurine. Eur J Clin Pharm 1992; 43: 329-339.
13. Seidman EG. Clinical Use and Practical Application of TPMT Enzyme and 6-Mercaptopurine Metabolite Monitoring in IBD. Rev Gastroenterol Disord 2003; 3: S30-S38.
14. Cuffari C, Hunt S, Bayless T. Utilization of erythrocyte 6-thioguanine metabolite levels to optimize azathioprine therapy in patients with inflammatory bowel disease. Gut 2001; 48: 642-646.
15. Indjova D, Shipkova M, Atanasova S et al. Determination of thiopurine methyltransferase phenotype in isolated human erythrocytes using a new simple nonradioactive HPLC method. Ther Drug Monit 2003; 25: 637-644.
16. Rumbo C, Emerick KM, Emre S, Schneider BL. Azathioprine metabolite measurements in the treatment of autoimmune hepatitis in pediatric patients: a preliminary report. J Pediatr Gastroenterol Nutr 2002; 35: 391-398.