Exploring the effect of xenon on biomembranes

Cellular and Molecular Biology Letters

Volumn 10, Issue 4, 2005, Pages 563-569

  Stimson, Lorna M ^a   Vattulainen, Ilpo ^b,c   Róg, Tomasz ^a,d   Karttunen, Mikko ^a  

^a AALTO UNIVERSITY   (Finland)

^b HELSINKI INSTITUTE OF PHYSICS   (Finland)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d JAGIELLONIAN UNIVERSITY   (Poland)

Author keywords

General Anaesthetics; Lipid Bilayer; Molecular Dynamics; Xenon

Indexed keywords

DIPALMITOYLPHOSPHATIDYLCHOLINE; XENON;

ARTICLE; ATOMIC PARTICLE; CELL MEMBRANE; CELL STIMULATION; HYDRATION; MEMBRANE; MOLECULAR DYNAMICS; SURFACE PROPERTY;

EID: 31544451534     PISSN: 14258153     EISSN: 16891392     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Eckenhoff, R.G. Promiscuous ligands and attractive cavities; how do the inhaled anesthetics work? Mol. Interv. 1 (2002) 258-268.
2. Tang, P. and Xu, Y. Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: the implication of molecular mechanisms of general anesthesia. Proc. Natl. Acad. Sci. USA 99 (2002) 16035-16040.
3. Koubi, L., Tarek, M., Klein, M.L. and Scharf, D. Distribution of halothane in a dipalmitoylphosphatidylcholine bilayer from molecular dynamics calculation. Biophys. J. 78 (2000) 800-811.
4. Pickholz, M., Saiz, L. and Klein, M.L. Concentration effects of volatile anesthetics on the properties of model membranes: A coarse-grain approach. Biophys. J. 88 (2005) 1524-1534.
5. Kranenburg, M. and Smit, B. Simulating the effect of alcohol on the structure of a membrane. FEBS Lett. 568 (2004) 15-18.
6. Feller, S.E., Brown, C.A., Nizza, D.T. and Gawrisch, K. Nuclear overhauser enhancement spectroscopy cross-relaxation rates and ethanol distribution across membranes. Biophys. J. 82 (2002) 1396-1404.
7. Lee, B.W., Faller, R., Sum, A.K., Vattulainen, I., Patra, M. and Karttunen, M. Structural effects of small molecules on phospholipid bilayers investigated. Fluid Phase Equilibria 225 (2004) 63-68.
8. Patra, M., Karttunen M., Hyvönen M., Falck E., Lindqvist, P. and Vattulainen I. Molecular dynamics of lipid bilayers: Major artifacts due to truncating electrostatic interactions. Biophys. J. 84 (2003) 3636-3645.
9. Tieleman, D.P. and Berendsen, H.J.C. Molecular dynamics simulations of a fully hydrated dipalmitoylphosphatidylcholine bilayer with different macroscopic boundary conditions and parameters. J. Chem. Phys. 105 (1996) 4871-4880.
10. Hirschfelder, J.O., Curtiss, C.F. and Bird, R.B. Molecular theory of gases and liquids. John Wiley & Sons, New York, 1954.
11. Berendsen, H.J.C., Postma, J.P.M., van der Gunsteren W.F. and Hermans, J. Interaction models for water in relation to protein hydration. In: Intermolecular forces. (Pullman, B. Ed.), Reidel, Dortrecht (1981) pp 331-342.
12. Lindahl, E., Hess, B. and van der Spoel, D. GROMACS 3.0: a package for molecular simulations and trajectory analysis. J. Mol. Mod. 7 (2004) 306.
13. Berendsen, H.J.C., Postma, J.P.M., van der Gunsteren W.F., DiNola, A. and Haak, J.R. Molecular dynamics with coupling to an external bath. J. Chem. Phys. 81 (1984) 3684-3690.
14. Hess, B., Bekker, H., Berendsen, H.J.C. and Fraaije, J.G.E.M. LINCS: A linear constraint solver for molecular simulations. J. Comput. Chem. 18 (1997) 1463-1472.
15. Oros, A. and Shah, N.J. Hyperpolarized xenon in NMR and MRI. Phys. Med. Biol. 49 (2004) 105-153.
16. 129Xe dissolved in a lipid emulsion. Life Sci. 323 (2000) 529-536.
17. Maria, N.S. and Eckmann, D.M. Model predictions of gas embolism growth and readsorption during xenon anesthesia. Anesthesiology 99 (2003) 638-645.
18. 1H} intermolecular nuclear Overhauser effects. Biochim. Biophys. Acta 1323 (1997) 154-162.
19. Marrink, S.J. and Berendsen, H.J.C. Permeation process of small molecules across lipid membranes studied by molecular dynamics simulations. J. Phys. Chem. 100 (1996) 16729-16738.
20. Falck, E., Patra, M., Karttunen, M., Hyvönen, M.T. and Vattulainen, I. Impact of Cholesterol on Voids in Phospholipid Membranes. J. Chem. Phys. 121 (2004) 12676.
21. Bemporad, D. and Essex, J.W. Permeation of small molecules through a lipid bilayer: A computer simulation study. J. Phys. Chem. B 108 (2004) 4875-4884.
22. Hoff, B., Strandberg, E., Ulrich, A.S., Tieleman, D.P. and Posten, C. H-2-NMR study and molecular dynamics simulation of the location, alignment, and mobility of pyrene in POPC bilayers. Biophys. J. 88 (2005) 1818-1827.
23. Patra, M., Salonen, E., Terama, E., Vattulainen, I., Faller, R., Lee, B.W., Holopainen, J. and Karttunen, M. Under the influence of alcohol: the effect of ethanol and methanol on lipid bilayers. Biophys. J., in press.
24. Cantor, R.S. The lateral pressure profile in membranes: a physical mechanism of general anesthesia. Toxicol. Lett. 101 (1998) 451.