Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: Possible relevance to depression and hyperactive-immune disorders

International Immunopharmacology

Volumn 8, Issue 4, 2008, Pages 526-533

  Taler, Michal ^a   Bar, Meytal ^a   Korob, Inna ^a   Lomnitski, Liat ^b   Baharav, Ehud ^c   Grunbaum Novak, Nurit ^a   Weizman, Abraham ^a,d   Gil Ad, Irit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b Perrigo Israel Pharmaceutical Ltd   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

^d GEHA MENTAL HEALTH CENTER   (Israel)

Author keywords

Antidepressants; Apoptosis; Cytokines; Splenocytes; SSRIs; TNF

Indexed keywords

ANTIDEPRESSANT AGENT; CLOMIPRAMINE; CONCANAVALIN A; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; PAROXETINE; PROTEIN BCL 2; SERTRALINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL LEVEL; CELL PROLIFERATION; CELL VIABILITY; DEPRESSION; DRUG EFFECT; DRUG INHIBITION; EX VIVO STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IC 50; IMMUNOMODULATION; IMMUNOPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPLEEN CELL; UPREGULATION;

ANIMALS; ANTIDEPRESSIVE AGENTS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CLOMIPRAMINE; CYCLOOXYGENASE 2; FEMALE; IMMUNE SYSTEM DISEASES; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MITOGEN-ACTIVATED PROTEIN KINASES; PAROXETINE; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, INBRED LEW; SERTRALINE; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 39949085778     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.12.003     Document Type: Article

References (34)

1. Taler M., Gil-Ad I., Lomnitski L., Korov I., Baharav E., Bar M., et al. Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol (2007) [Electronic publication ahead of print]
2. Levkovitz Y., Gil-Ad I., Zeldich E., Dayag M., and Weizman A. Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. J Mol Neurosci 27 1 (2005) 29-42
3. Arimochi H., and Morita K. Characterization of cytotoxic actions of tricyclic antidepressants on human HT29 colon carcinoma cells. Eur J Pharmacol 541 (2006) 17-23
4. 2+ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol 95 3 (2004) 124-130
5. Xu W., Tamim H., Shapiro S., Stang M.R., and Collet J.P. Use of antidepressants and risk of colorectal cancer: a nested case-control study. Lancer Oncol 7 (2006) 301-308
6. Stockler M.R., O'connell R., Nowak A.K., Goldstein D., Turner J., Wilcken N.R., et al. Effect of sertraline on symptoms and survival in patients with advanced cancer, but without major depression: a placebo-controlled double-blind randomised trial. Lancet Oncol 8 7 (2007) 603-612
7. Gordon J., and Nicholas M.B. Lymphocytes transport serotonin and dopamine: agony or ecstasy?. TRENDS in Immunol 24 8 (2003) 438-443
8. Barkan T., Gurwitz D., Levy G., Weizman A., and Rehavi M. Biochemical and pharmacological characterization of the serotonin transporter in human peripheral blood lymphocytes. Eur Neuropsychopharmacol 14 3 (2004) 237-243
9. Donaldson T.A. Immune responses to infection. Crit Care Nurs Clin North Am 19 1 (2007) 1-8
10. Murphy K.M., and Reiner S.L. The lineage decision of helper T cells. Nat Rev Immunol 2 (2002) 933-944
11. Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuro-Psychopharmacol Biol Psychiatry 19 (1995) 11-38
12. Miller G.E., Cohen S., and Ritchey A.K. Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol 21 (2002) 531-541
13. Bogoyevitch M.A., and Court N.W. Counting on mitogen-activated protein kinases-ERKs 3, 4, 5, 6, 7 and 8. Cell Signal 16 (2004) 1345-1354
14. Okuyama-Tamura M., Mikuni M., and Kojima I. Modulation of the human glucocorticoid receptor function by antidepressive compounds. Neurosci Lett 342 3 (2003) 206-210
15. Williams C.S., Mann M., and DuBois R.N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 18 (1999) 7908-7916
16. Müller N., Schwarz M.J., Dehning S., Douhe A., Cerovecki A., Goldstein-Müller B., et al. The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 11 (2006) 680-684
17. Ahmed S.A., Gogal R.M., and Walsh J.E. A new rapid and simple non-radioactive assay to monitor and determine proliferation of lymphocytes: an alternative to {3H} thymidine incorporation assay. J Immunol Methods 170 (1994) 211-224
18. Tibbles L.A., and Woodgett J.R. The stress-activated protein kinases pathways. Cell Mol Life Sci 55 (1999) 1230-1254
19. Seger R., and Krebs E.G. The MAPK signaling cascade. FASEB J 9 (1995) 726-735
20. Green D.R., and Reed J.C. Mitochondria and apoptosis. Science 281 (1998) 1309-1312
21. Pae C.U., and Patkar A.A. Paroxetine: current status in psychiatry. Expert Rev Neurother 7 3 (2007) 107-120
22. Tonelli L.H., Holmes A., and Postolache T.T. Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain. Neuropsychopharmacology 27 (2007) [Electronic publication ahead of print]
23. Leonard B.E. The immune system, depression and the action of antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 25 4 (2001) 767-780
24. Crowson A.N., and Magro C.M. Antidepressant therapy: a possible cause of atypical cutaneous lymphoid hyperplasia. Arch Dermatol 131 (1995) 925-929
25. Roumestan C., Michel A., Bichon F., Portet K., Detoc M., Henriquet C., et al. Anti-inflammatory properties of desipramine and fluoxetine. Respir Res (2007) [Electronic publication ahead of print]
26. Kirchherr H., and Kühn-Velten W.N. Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach. J Chromatogr B 843 (2006) 100-113
27. Nordenberg J., Fenning E., Landau M., Weizman R., and Weizman A. Effect of psychotrophic drugs on cell proliferation and differentiation. Biochem Pharmacol 58 (1999) 1229-1236
28. Gil-Ad I., Shtaif B., Levkovitz Y., Nordenberg J., Taler M., Korov I., et al. Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth. Oncol Rep 15 1 (2006) 107-112
29. Serafeim A., Holder M.J., Grafton G., Chamba A., Drayson M.T., Luong Q.T., et al. Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells. Blood 15 (2002) 3212-3219
30. Chou C.T., He S., and Jan C.R. Paroxetine-induced apoptosis in human osteosarcoma cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation. Toxicol Appl Pharmacol 218 3 (2007) 265-273
31. Xia Z., DePierre J.W., and Nassberger L. Modulation of apoptosis induced by tricyclic antidepressants in human peripheral lymphocytes. J Biochem Mol Toxicol 12 2 (1998) 115-123
32. Xia Z., Bergstrand A., DePierre J.W., and Nassberger L. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol 13 6 (1999) 338-347
33. Chen S.J., Kao C.L., Chang Y.L., Yen C.J., Shui J.W., Chien C.S., et al. Antidepressant administration modulates neural stem cell survival and serotonergic differentiation through bcl-2. Curr Neurovasc Res 4 1 (2007) 19-29
34. Cenci S., Weitzmann M.N., Roggia C., Namba N., Novack D., Woodring J., et al. Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest 106 (2000) 1229-1237