Endothelial nitric oxide synthase gene (T-786C) polymorphism in patients with slow coronary flow

Coronary Artery Disease

Volumn 19, Issue 2, 2008, Pages 85-88

  Nurkalem, Zekeriya ^a,b   Tangurek, Burak ^a   Zencirci, Ertugrul ^a   Alper, Ahmet T ^a   Aksu, Huseyin ^a   Erer, Betul ^a   Gorgulu, Sevket ^a   Ciloglu, Figen ^a   Eren, Mehmet ^a  

^a DR SIYAMI ERSEK THORACIC AND CARDIOVASCULAR SURGERY TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b Training and Research Hospital   (Turkey)

Author keywords

Endothelial nitric oxide synthase gene; Nitric oxide; Slow coronary flow; T 786C polymorphism

Indexed keywords

ANTIHYPERTENSIVE AGENT; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IOPROMIDE;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HOMOZYGOSITY; HUMAN; HYPERTENSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY VESSELS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEMORHEOLOGY; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 39849106614     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCA.0b013e3282f52940     Document Type: Article

References (26)

1. Moncada S, Higgs A. The L-arginine-nitric oxide pathway. N Engl J Med 1993; 329:2002-2012.
2. Quyyumi AA, Dakak N, Andrews NP, Husain S, Arora S, Gilligan DM, et al. Nitric oxide activity in the human coronary circulation. J Clin Invest 1995; 95:1747-1755.
3. Ohashi Y, Kawashima S, Hirata K, Yamashita T, Hirata K, Ohashi Y, et al. Hypotension and reduced nitric-elicited vasorelaxation in transgenic mice overexpressing endothelial nitric oxide synthase. J Clin Invest 1998; 2:2061-2071.
4. Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 1996; 94:266-271.
5. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, et al. T-786C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99:2864-2870.
6. Nakayama M, Yoshimura M, Sakamoto T, Abe K, Yamamuro M, Shono M, et al. A-786T > C polymorphism in the endothelial nitric oxide synthase gene reduces serum nitrite/nitrate levels from the heart due to an intracoronary injection of acetylcholine. Pharmacogenet Genomics 2006; 16:339-345.
7. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries: a new angiographic finding. Am Heart J 1972; 84:66-71.
8. Sezgin AT, Sigirci M, Barutcu I, Topal E, Sezgin N, Ozdemir R, et al. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 2003; 14:155-161.
9. Masseri M, Yorom R, Gotsman MS, Hasin Y. Histologic evidence for small vessel coronary artery disease in patients with angina pectoris and patent large coronay arteries. Circulation 1986; 74:964-972.
10. Mangieri M, Machiarelli G, Ciavolella M, Barilla F, Avella A, Martinotti A. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Catheter Cardiovasc Diagn 1996; 37:375-381.
11. Camsari A, Pekdemir H, Cicek D, Polat G, Akkus MN, Doven O, et al. Endothelin-1 and nitric oxide concentrations and their response to exercise in patients with slow coronary flow. Circ J 2003; 67: 1022-1028.
12. Sezgin N, Barutcu I, Sezgin AT, Gullu H, Turkmen M, Esen AM, et al. Plasma nitric oxide levels and its role in slow coronary flow phenomenon. Int Heart J 2005; 46:373-382.
13. Gibson CM, Cannon CP, Daley WL, Dodge JT, Alexander BJ, Marble SJ, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996; 93:879-888.
14. John SWM, Weitzner G, Rozen R, Scriver CR. A rapid procedure for extracting genomic DNA from leukocytes. Nucl Acids Res 1991; 25:408.
15. Hibi K, Ishigami T, Tamura K, Mizushima S, Nyui N, Fujita T, et al. Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 1998; 32:521-526.
16. Hyndman ME, Parsons HG, Verma S, Bridge PJ, Edworthy S, Jones C, et al. The T-786C mutation in endothelial nitric oxide synthase is associated with hypertension. Hypertension 2002; 39:919-922.
17. Hingorani AD, Liang CF, Fatibene J, Lyon A, Monteith S, Parsons A, et al. A common variant of the endothelial nitric oxide synthase (Glu298Asp) is a major risk factor for coronary artery disease in the UK. Circulation 1999; 100:1515-1520.
18. Colombo MG, Paradossi U, Andreassi MG, Botto N, Manfredi S, Biagini A, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem 2003; 49:389-395.
19. Rossi GP, Cesari M, Zanchetta M, Colonna S, Maiolino G, Pedon L, et al. The T-786C endothelial nitric oxide synthase genotype is a novel risk factor for coronary artery disease in Causian patients of the GENICA study. J Am Coll Cardiol 2003; 41:930-937.
20. Tangurek B, Ozer N, Sayar N, Terzi S, Yilmaz H, Dayi SU, et al. The relationship between endothelial nitric oxide synthase gene polymorphism (T-786C) and coronary artery disease in the Turkish population. Heart Vessels 2006; 21:285-290.
21. Shimasaki Y, Yasue H, Yoshimura M, Nakayama M, Kugiyama K, Ogawa H. Association of the missense Glu298 Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 1998; 31:1506-1510.
22. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Ogawa H, Kugiyama K, et al. T-786C mutation in the 5′ flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. Am J Cardiol 2000; 86:628-634.
23. Rossi GP, Taddei S, Virdis A, Cavallin M, Ghiadoni L, Favilla S, et al. The T-786C and Glu298Asp polymorphisms of the endothelial nitric oxide synthase gene affect the forearm blood flow responses of Caucasian hypertensive patients. J Am Coll Cardiol 2003; 41:938-945.
24. Paradossi U, Ciofini E, Clerico A, Botto N, Biagini A, Colombo MG. Endothelial function and carotid intima-media thickness in young healthy subjects among endothelial nitric oxide synthase Glu298Asp and T786C polymorphisms. Stroke 2004; 35:1305-1309.
25. Erbs S, Mobius-Winkler S, Linke A, Adams V, Doll N, Gielen S, et al. Both T-786C and G894T polymorphism of endothelial nitric oxide synthase affect in-vitro endothelium-dependent relaxation of internal mammary artery rings from patients with coronary artery disease. Eur J Cardiovasc Prev Rehab 2006; 13:826-831.
26. Appleby MA, Michaels AD, Chen M, Michael CG. Importance of the TIMI frame count: implications for future trials. Curr Control Trials Cardiovasc Med 2000; 1:31-34.